eF-site/Summary 2wbj-ABCDEFGH

eF-site ID	2wbj-ABCDEFGH
PDB Code	2wbj
Chain	A, B, C, D, E, F, G, H

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Title	TCR complex
Classification	IMMUNE SYSTEM
Compound	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN
Source	(2WBJ)

Sequence	A:	EEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETV WRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPI TNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWL RNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYD CRVEHWGLDEPLLKHWEF
	B:	TRPRFLWQPKRECHFFNGTERVRFLDRYFYNQEESVRFDS DVGEFRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHN YGVVESFTVQRRVQPKVTVYPSKTQPHHNLLVCSVSGFYP GSIEVRWFLNGQEEKAGMVSTGLIQNGDWTFQTLVMLETV PYTCQVEHPSVTSPLTVEW
	C:	PQALSIQEGENATMNCSYKTSINNLQWYRQNSGRGLVHLI LIRSNEREKHSGRLRVTLDTSKKSSSLLITASRAADTASY FCATDTTSGTYKYIFGTGTRLKVLPNIQNPDPAVYQLRDS KSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSM DFKSNSAVAWSNKSDFACANAFNNSIIPEDTFF
	D:	MDFARVHFISALHGSGGGSGGGGGAVVSQHPSWVISKSGT SVKIECRSLDFQATTMFWYRQFPKQSLMLMATSNEGSKAT YEQGVEKDKFLINHASLTLSTLTVTSAHPEDSSFYICSAR DLTSGANNEQFFGPGTRLTVTEDLKNVFPPEVAVFEPSEA EISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTD PQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQ FYGLSENDEWTQDRAKPVTQIVSAEAWGRS
	E:	EHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVW RLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPIT NVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLR NGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDC RVEHWGLDEPLLKHWEF
	F:	TRPRFLWQPKRECHFFNGTERVRFLDRYFYNQEESVRFDS DVGEFRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHN YGVVESFTVQRRVQPKVTVYPSKTQPLQHHNLLVCSVSGF YPGSIEVRWFLNGQEEKAGMVSTGLIQNGDWTFQTLVMLE TVPRSGEVYTCQVEHPSVTSPLTVEWRA
	G:	ALSIQEGENATMNCSYKTSINNLQWYRQNSGRGLVHLILI RSNEREKHSGRLRVTLDTSKKSSSLLITASRAADTASYFC ATDTTSGTYKYIFGTGTRLKVLPNIQNPDPAVYQLRSSDK SVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSN SAVAWSNKSDFACANAFNNSIIPEDTFFPS
	H:	DFARVHFISALHGSGGVVSQHPSWVISKSGTSVKIECRSL DFQATTMFWYRQFPKQSLMLMATSNEGSKATYEQGVEKDK FLINHASLTLSTLTVTSAHPEDSSFYICSARDLTSGANNE QFFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKAT LVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPA LNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDE WTQDRAKPVTQIVSAEAWGR

Description

Functional site


1)	chain	B
	residue	57
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI2

2)	chain	B
	residue	61
	type	BINDING
	sequence	W
	description	BINDING => ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI2

3)	chain	B
	residue	81
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI2

4)	chain	B
	residue	82
	type	BINDING
	sequence	N
	description	BINDING => ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI2

5)	chain	F
	residue	57
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI2

6)	chain	F
	residue	61
	type	BINDING
	sequence	W
	description	BINDING => ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI2

7)	chain	F
	residue	81
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI2

8)	chain	F
	residue	82
	type	BINDING
	sequence	N
	description	BINDING => ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI2

9)	chain	B
	residue	93
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI3

10)	chain	F
	residue	93
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI3

11)	chain	E
	residue	49
	type	BINDING
	sequence	G
	description	BINDING => ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI3

12)	chain	E
	residue	52
	type	BINDING
	sequence	A
	description	BINDING => ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI3

13)	chain	B
	residue	19
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19303388, ECO:0000269\|PubMed:24190431
	source	Swiss-Prot : SWS_FT_FI4

14)	chain	F
	residue	19
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19303388, ECO:0000269\|PubMed:24190431
	source	Swiss-Prot : SWS_FT_FI4

15)	chain	A
	residue	161-167
	type	prosite
	sequence	YDCRVEH
	description	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH
	source	prosite : PS00290

16)	chain	B
	residue	171-177
	type	prosite
	sequence	YTCQVEH
	description	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH
	source	prosite : PS00290

17)	chain	A
	residue	78
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:7477400
	source	Swiss-Prot : SWS_FT_FI10

18)	chain	A
	residue	118
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:7477400
	source	Swiss-Prot : SWS_FT_FI10

19)	chain	E
	residue	78
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:7477400
	source	Swiss-Prot : SWS_FT_FI10

20)	chain	E
	residue	118
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:7477400
	source	Swiss-Prot : SWS_FT_FI10

21)	chain	A
	residue	55
	type	SITE
	sequence	E
	description	Pathogen-derived peptide antigen => ECO:0000269\|PubMed:23260142, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI6

22)	chain	E
	residue	55
	type	SITE
	sequence	E
	description	Pathogen-derived peptide antigen => ECO:0000269\|PubMed:23260142, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI6

23)	chain	A
	residue	62
	type	SITE
	sequence	N
	description	Self- and pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:21115828, ECO:0000269\|PubMed:23260142, ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI7

24)	chain	E
	residue	62
	type	SITE
	sequence	N
	description	Self- and pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:21115828, ECO:0000269\|PubMed:23260142, ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI7

25)	chain	A
	residue	69
	type	SITE
	sequence	N
	description	Pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:21115828, ECO:0000269\|PubMed:23260142, ECO:0000269\|PubMed:8145819, ECO:0007744\|PDB:4FQX, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI8

26)	chain	E
	residue	69
	type	SITE
	sequence	N
	description	Pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:21115828, ECO:0000269\|PubMed:23260142, ECO:0000269\|PubMed:8145819, ECO:0007744\|PDB:4FQX, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI8

27)	chain	A
	residue	76
	type	SITE
	sequence	R
	description	Self- and pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:23260142, ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819, ECO:0007744\|PDB:4FQX, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI9

28)	chain	E
	residue	76
	type	SITE
	sequence	R
	description	Self- and pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:23260142, ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819, ECO:0007744\|PDB:4FQX, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI9

29)	chain	A
	residue	53
	type	SITE
	sequence	S
	description	Self- and pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:21115828, ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI5

30)	chain	E
	residue	53
	type	SITE
	sequence	S
	description	Self- and pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:21115828, ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI5