eF-site ID 2w72-B PDB Code 2w72 Chain B click to enlarge Title DEOXYGENATED STRUCTURE OF A DISTAL SITE HEMOGLOBIN MUTANT PLUS XE Classification OXYGEN TRANSPORT Compound HUMAN HEMOGLOBIN A Source (HBA_HUMAN) Sequence B:  MHLTPEEKSAVTALWGKVNVDEVGGEAYGRLLVVYPWTQR FFESFGDLSTPDAVMGNPKVKAQGKKVLGAFSDGLAHLDN LKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGK EFTPPVQAAYQKVVAGVANALAHKYH Description Functional site 1) chain B residue 28 type sequence Y description BINDING SITE FOR RESIDUE HEM B 1147 source : AC2 2) chain B residue 41 type sequence F description BINDING SITE FOR RESIDUE HEM B 1147 source : AC2 3) chain B residue 63 type sequence Q description BINDING SITE FOR RESIDUE HEM B 1147 source : AC2 4) chain B residue 66 type sequence K description BINDING SITE FOR RESIDUE HEM B 1147 source : AC2 5) chain B residue 67 type sequence V description BINDING SITE FOR RESIDUE HEM B 1147 source : AC2 6) chain B residue 92 type sequence H description BINDING SITE FOR RESIDUE HEM B 1147 source : AC2 7) chain B residue 96 type sequence L description BINDING SITE FOR RESIDUE HEM B 1147 source : AC2 8) chain B residue 102 type sequence N description BINDING SITE FOR RESIDUE HEM B 1147 source : AC2 9) chain B residue 103 type sequence F description BINDING SITE FOR RESIDUE HEM B 1147 source : AC2 10) chain B residue 141 type sequence L description BINDING SITE FOR RESIDUE HEM B 1147 source : AC2 11) chain B residue 120 type sequence K description BINDING SITE FOR RESIDUE SO4 D 1148 source : AC6 12) chain B residue 1 type sequence M description BINDING SITE FOR RESIDUE SO4 B 1148 source : AC7 13) chain B residue 80 type sequence N description BINDING SITE FOR RESIDUE SO4 B 1148 source : AC7 14) chain B residue 81 type sequence L description BINDING SITE FOR RESIDUE SO4 B 1148 source : AC7 15) chain B residue 82 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1148 source : AC7 16) chain B residue 116 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1149 source : AC9 17) chain B residue 117 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1149 source : AC9 18) chain B residue 51 type sequence P description BINDING SITE FOR RESIDUE SO4 A 1145 source : BC3 19) chain B residue 62 type sequence A description BINDING SITE FOR RESIDUE K B 1150 source : BC5 20) chain B residue 65 type sequence K description BINDING SITE FOR RESIDUE K B 1150 source : BC5 21) chain B residue 66 type sequence K description BINDING SITE FOR RESIDUE K B 1150 source : BC5 22) chain B residue 71 type sequence F description BINDING SITE FOR RESIDUE XE B 1151 source : DC1 23) chain B residue 103 type sequence F description BINDING SITE FOR RESIDUE XE B 1151 source : DC1 24) chain B residue 106 type sequence L description BINDING SITE FOR RESIDUE XE B 1151 source : DC1 25) chain B residue 110 type sequence L description BINDING SITE FOR RESIDUE XE B 1151 source : DC1 26) chain B residue 134 type sequence V description BINDING SITE FOR RESIDUE XE B 1151 source : DC1 27) chain B residue 24 type sequence G description BINDING SITE FOR RESIDUE XE B 1152 source : DC2 28) chain B residue 68 type sequence L description BINDING SITE FOR RESIDUE XE B 1152 source : DC2 29) chain B residue 2 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00238 source Swiss-Prot : SWS_FT_FI1 30) chain B residue 82 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00238 source Swiss-Prot : SWS_FT_FI1 31) chain B residue 143 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00238 source Swiss-Prot : SWS_FT_FI1 32) chain B residue 17 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI13 33) chain B residue 66 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI13 34) chain B residue 120 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI13 35) chain B residue 144 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI14 36) chain B residue 74 type SITE sequence G description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI4 37) chain B residue 84 type SITE sequence T description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI4 38) chain B residue 92 type SITE sequence H description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI4 39) chain B residue 104 type SITE sequence R description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI4 40) chain B residue 110 type SITE sequence L description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI4 41) chain B residue 119 type SITE sequence G description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI4 42) chain B residue 122 type SITE sequence F description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI4 43) chain B residue 128 type SITE sequence A description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI4 44) chain B residue 140 type SITE sequence A description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI4 45) chain B residue 144 type SITE sequence K description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI4 46) chain B residue 45 type SITE sequence F description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI4 47) chain B residue 52 type SITE sequence D description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI4 48) chain B residue 56 type SITE sequence G description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI4 49) chain B residue 71 type SITE sequence F description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI4 50) chain B residue 44 type MOD_RES sequence S description Phosphothreonine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7 51) chain B residue 50 type MOD_RES sequence T description N6-succinyllysine => ECO:0000250|UniProtKB:P01942 source Swiss-Prot : SWS_FT_FI8 52) chain B residue 87 type MOD_RES sequence T description N6-succinyllysine => ECO:0000250|UniProtKB:P01942 source Swiss-Prot : SWS_FT_FI8 53) chain B residue 82 type MOD_RES sequence K description Phosphotyrosine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI9

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