eF-site ID 2w6n-B PDB Code 2w6n Chain B click to enlarge Title Crystal structure of Biotin carboxylase from E. coli in complex with amino-oxazole fragment series Classification LIGASE Compound BIOTIN CARBOXYLASE Source Escherichia coli (strain K12) (ACCC_ECOLI) Sequence B:  MLDKIVIANRGEIALRILRACKELGIKTVAVHSSADRDLK HVLLADETVCIGPAPSVKSYLNIPAIISAAEITGAVAIHP GYGFLSENANFAEQVERSGFIFIGPKAETIRLMGDKVSAI AAMKKAGVPCVPGSDGPLGDDMDKNRAIAKRIGYPVIIKA SGGGGGRGMRVVRGDAELAQSISMTRAEAKAAFSNDMVYM EKYLENPRHVEIQVLADGQGNAIYLAERDCSMQRRHQKVV EEAPAPGITPELRRYIGERCAKACVDIGYRGAGTFEFLFE NGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIAAGQP LSIKQEEVHVRGHAVECRINAEDPNTFLPSPGKITRFHAP GGFGVRWESHIYAGYTVPPYYDSMIGKLICYGENRDVAIA RMKNALQELIIDGIKTNVDLQIRIMNDENFQHGGTNIHYL EKKLG Description Functional site 1) chain B residue 157 type sequence I description BINDING SITE FOR RESIDUE OA2 B 1446 source : AC2 2) chain B residue 159 type sequence K description BINDING SITE FOR RESIDUE OA2 B 1446 source : AC2 3) chain B residue 201 type sequence E description BINDING SITE FOR RESIDUE OA2 B 1446 source : AC2 4) chain B residue 202 type sequence K description BINDING SITE FOR RESIDUE OA2 B 1446 source : AC2 5) chain B residue 203 type sequence Y description BINDING SITE FOR RESIDUE OA2 B 1446 source : AC2 6) chain B residue 204 type sequence L description BINDING SITE FOR RESIDUE OA2 B 1446 source : AC2 7) chain B residue 278 type sequence L description BINDING SITE FOR RESIDUE OA2 B 1446 source : AC2 8) chain B residue 437 type sequence I description BINDING SITE FOR RESIDUE OA2 B 1446 source : AC2 9) chain B residue 292 type sequence R description BINDING SITE FOR RESIDUE CL B 1447 source : AC4 10) chain B residue 294 type sequence Q description BINDING SITE FOR RESIDUE CL B 1447 source : AC4 11) chain B residue 295 type sequence V description BINDING SITE FOR RESIDUE CL B 1447 source : AC4 12) chain B residue 338 type BINDING sequence R description BINDING => ECO:0000269|PubMed:19213731, ECO:0007744|PDB:3G8C source Swiss-Prot : SWS_FT_FI5 13) chain B residue 209 type BINDING sequence H description BINDING => ECO:0000269|PubMed:19213731, ECO:0007744|PDB:3G8C source Swiss-Prot : SWS_FT_FI5 14) chain B residue 238 type BINDING sequence K description BINDING => ECO:0000269|PubMed:19213731, ECO:0007744|PDB:3G8C source Swiss-Prot : SWS_FT_FI5 15) chain B residue 292 type BINDING sequence R description BINDING => ECO:0000269|PubMed:19213731, ECO:0007744|PDB:3G8C source Swiss-Prot : SWS_FT_FI5 16) chain B residue 295 type BINDING sequence V description BINDING => ECO:0000269|PubMed:19213731, ECO:0007744|PDB:3G8C source Swiss-Prot : SWS_FT_FI5 17) chain B residue 236 type BINDING sequence H description BINDING => ECO:0000269|PubMed:10821865, ECO:0000269|PubMed:19213731, ECO:0007744|PDB:1DV2, ECO:0007744|PDB:3G8C source Swiss-Prot : SWS_FT_FI6 18) chain B residue 292 type ACT_SITE sequence R description ACT_SITE => ECO:0000269|PubMed:19213731 source Swiss-Prot : SWS_FT_FI1 19) chain B residue 116 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10821865, ECO:0000269|PubMed:19213731, ECO:0007744|PDB:1DV2, ECO:0007744|PDB:3G8D source Swiss-Prot : SWS_FT_FI2 20) chain B residue 165 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10821865, ECO:0000269|PubMed:19213731, ECO:0007744|PDB:1DV2, ECO:0007744|PDB:3G8D source Swiss-Prot : SWS_FT_FI2 21) chain B residue 159 type BINDING sequence K description BINDING => ECO:0000269|PubMed:19213731, ECO:0007744|PDB:3G8C, ECO:0007744|PDB:3G8D source Swiss-Prot : SWS_FT_FI3 22) chain B residue 201 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10821865, ECO:0000269|PubMed:19213731, ECO:0007744|PDB:1DV2, ECO:0007744|PDB:3G8C, ECO:0007744|PDB:3G8D source Swiss-Prot : SWS_FT_FI4 23) chain B residue 276 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00409 source Swiss-Prot : SWS_FT_FI7 24) chain B residue 288 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00409 source Swiss-Prot : SWS_FT_FI7 25) chain B residue 290 type BINDING sequence N description BINDING => ECO:0000255|PROSITE-ProRule:PRU00409 source Swiss-Prot : SWS_FT_FI7

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