eF-site ID 2w6m-AB
PDB Code 2w6m
Chain A, B

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Title Crystal structure of Biotin carboxylase from E. coli in complex with amino-oxazole fragment series
Classification LIGASE
Compound BIOTIN CARBOXYLASE
Source Escherichia coli (strain K12) (ACCC_ECOLI)
Sequence A:  MLDKIVIANRGEIALRILRACKELGIKTVAVHSSADRDLK
HVLLADETVCIGPAPSVKSYLNIPAIISAAEITGAVAIHP
GYGFLSENANFAEQVERSGFIFIGPKAETIRLMGDKVSAI
AAMKKAGVPCVPGSDGPLGDDMDKNRAIAKRIGYPVIIKA
SGGGGGRGMRVVRGDAELAQSISMTRAEAKAAFSNDMVYM
EKYLENPRHVEIQVLADGQGNAIYLAERDCSMQRRHQKVV
EEAPAPGITPELRRYIGERCAKACVDIGYRGAGTFEFLFE
NGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIAAGQP
LSIKQEEVHVRGHAVECRINAEDPNTFLPSPGKITRFHAP
GGFGVRWESHIYAGYTVPPYYDSMIGKLICYGENRDVAIA
RMKNALQELIIDGIKTNVDLQIRIMNDENFQHGGTNIHYL
EKKLGLQ
B:  MLDKIVIANRGEIALRILRACKELGIKTVAVHSSADRDLK
HVLLADETVCIGPAPSVKSYLNIPAIISAAEITGAVAIHP
GYGFLSENANFAEQVERSGFIFIGPKAETIRLMGDKVSAI
AAMKKAGVPCVPGSDGPLGDDMDKNRAIAKRIGYPVIIKA
SGGGGGRGMRVVRGDAELAQSISMTRAEAKAAFSNDMVYM
EKYLENPRHVEIQVLADGQGNAIYLAERDCSMQRRHQKVV
EEAPAPGITPELRRYIGERCAKACVDIGYRGAGTFEFLFE
NGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIAAGQP
LSIKQEEVHVRGHAVECRINAEDPNTFLPSPGKITRFHAP
GGFGVRWESHIYAGYTVPPYYDSMIGKLICYGENRDVAIA
RMKNALQELIIDGIKTNVDLQIRIMNDENFQHGGTNIHYL
EKKLGL
Description


Functional site

1) chain A
residue 131
type
sequence V
description BINDING SITE FOR RESIDUE OA1 A 1447
source : AC1

2) chain A
residue 157
type
sequence I
description BINDING SITE FOR RESIDUE OA1 A 1447
source : AC1

3) chain A
residue 159
type
sequence K
description BINDING SITE FOR RESIDUE OA1 A 1447
source : AC1

4) chain A
residue 169
type
sequence M
description BINDING SITE FOR RESIDUE OA1 A 1447
source : AC1

5) chain A
residue 201
type
sequence E
description BINDING SITE FOR RESIDUE OA1 A 1447
source : AC1

6) chain A
residue 202
type
sequence K
description BINDING SITE FOR RESIDUE OA1 A 1447
source : AC1

7) chain A
residue 203
type
sequence Y
description BINDING SITE FOR RESIDUE OA1 A 1447
source : AC1

8) chain A
residue 204
type
sequence L
description BINDING SITE FOR RESIDUE OA1 A 1447
source : AC1

9) chain A
residue 278
type
sequence L
description BINDING SITE FOR RESIDUE OA1 A 1447
source : AC1

10) chain A
residue 437
type
sequence I
description BINDING SITE FOR RESIDUE OA1 A 1447
source : AC1

11) chain B
residue 131
type
sequence V
description BINDING SITE FOR RESIDUE OA1 B 1446
source : AC2

12) chain B
residue 159
type
sequence K
description BINDING SITE FOR RESIDUE OA1 B 1446
source : AC2

13) chain B
residue 169
type
sequence M
description BINDING SITE FOR RESIDUE OA1 B 1446
source : AC2

14) chain B
residue 201
type
sequence E
description BINDING SITE FOR RESIDUE OA1 B 1446
source : AC2

15) chain B
residue 202
type
sequence K
description BINDING SITE FOR RESIDUE OA1 B 1446
source : AC2

16) chain B
residue 203
type
sequence Y
description BINDING SITE FOR RESIDUE OA1 B 1446
source : AC2

17) chain B
residue 204
type
sequence L
description BINDING SITE FOR RESIDUE OA1 B 1446
source : AC2

18) chain B
residue 236
type
sequence H
description BINDING SITE FOR RESIDUE OA1 B 1446
source : AC2

19) chain B
residue 278
type
sequence L
description BINDING SITE FOR RESIDUE OA1 B 1446
source : AC2

20) chain B
residue 437
type
sequence I
description BINDING SITE FOR RESIDUE OA1 B 1446
source : AC2

21) chain A
residue 292
type
sequence R
description BINDING SITE FOR RESIDUE CL A 1448
source : AC3

22) chain A
residue 294
type
sequence Q
description BINDING SITE FOR RESIDUE CL A 1448
source : AC3

23) chain A
residue 295
type
sequence V
description BINDING SITE FOR RESIDUE CL A 1448
source : AC3

24) chain B
residue 292
type
sequence R
description BINDING SITE FOR RESIDUE CL B 1447
source : AC4

25) chain B
residue 295
type
sequence V
description BINDING SITE FOR RESIDUE CL B 1447
source : AC4

26) chain A
residue 292
type ACT_SITE
sequence R
description ACT_SITE => ECO:0000269|PubMed:19213731
source Swiss-Prot : SWS_FT_FI1

27) chain B
residue 292
type ACT_SITE
sequence R
description ACT_SITE => ECO:0000269|PubMed:19213731
source Swiss-Prot : SWS_FT_FI1

28) chain A
residue 116
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:10821865, ECO:0000269|PubMed:19213731, ECO:0007744|PDB:1DV2, ECO:0007744|PDB:3G8D
source Swiss-Prot : SWS_FT_FI2

29) chain A
residue 165
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:10821865, ECO:0000269|PubMed:19213731, ECO:0007744|PDB:1DV2, ECO:0007744|PDB:3G8D
source Swiss-Prot : SWS_FT_FI2

30) chain B
residue 116
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:10821865, ECO:0000269|PubMed:19213731, ECO:0007744|PDB:1DV2, ECO:0007744|PDB:3G8D
source Swiss-Prot : SWS_FT_FI2

31) chain B
residue 165
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:10821865, ECO:0000269|PubMed:19213731, ECO:0007744|PDB:1DV2, ECO:0007744|PDB:3G8D
source Swiss-Prot : SWS_FT_FI2

32) chain A
residue 159
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:19213731, ECO:0007744|PDB:3G8C, ECO:0007744|PDB:3G8D
source Swiss-Prot : SWS_FT_FI3

33) chain B
residue 159
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:19213731, ECO:0007744|PDB:3G8C, ECO:0007744|PDB:3G8D
source Swiss-Prot : SWS_FT_FI3

34) chain A
residue 201
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:10821865, ECO:0000269|PubMed:19213731, ECO:0007744|PDB:1DV2, ECO:0007744|PDB:3G8C, ECO:0007744|PDB:3G8D
source Swiss-Prot : SWS_FT_FI4

35) chain B
residue 201
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:10821865, ECO:0000269|PubMed:19213731, ECO:0007744|PDB:1DV2, ECO:0007744|PDB:3G8C, ECO:0007744|PDB:3G8D
source Swiss-Prot : SWS_FT_FI4

36) chain A
residue 209
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:19213731, ECO:0007744|PDB:3G8C
source Swiss-Prot : SWS_FT_FI5

37) chain B
residue 338
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:19213731, ECO:0007744|PDB:3G8C
source Swiss-Prot : SWS_FT_FI5

38) chain A
residue 238
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:19213731, ECO:0007744|PDB:3G8C
source Swiss-Prot : SWS_FT_FI5

39) chain A
residue 292
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:19213731, ECO:0007744|PDB:3G8C
source Swiss-Prot : SWS_FT_FI5

40) chain A
residue 295
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:19213731, ECO:0007744|PDB:3G8C
source Swiss-Prot : SWS_FT_FI5

41) chain A
residue 338
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:19213731, ECO:0007744|PDB:3G8C
source Swiss-Prot : SWS_FT_FI5

42) chain B
residue 209
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:19213731, ECO:0007744|PDB:3G8C
source Swiss-Prot : SWS_FT_FI5

43) chain B
residue 238
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:19213731, ECO:0007744|PDB:3G8C
source Swiss-Prot : SWS_FT_FI5

44) chain B
residue 292
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:19213731, ECO:0007744|PDB:3G8C
source Swiss-Prot : SWS_FT_FI5

45) chain B
residue 295
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:19213731, ECO:0007744|PDB:3G8C
source Swiss-Prot : SWS_FT_FI5

46) chain A
residue 236
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:10821865, ECO:0000269|PubMed:19213731, ECO:0007744|PDB:1DV2, ECO:0007744|PDB:3G8C
source Swiss-Prot : SWS_FT_FI6

47) chain B
residue 236
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:10821865, ECO:0000269|PubMed:19213731, ECO:0007744|PDB:1DV2, ECO:0007744|PDB:3G8C
source Swiss-Prot : SWS_FT_FI6

48) chain A
residue 276
type BINDING
sequence E
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00409
source Swiss-Prot : SWS_FT_FI7

49) chain A
residue 288
type BINDING
sequence E
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00409
source Swiss-Prot : SWS_FT_FI7

50) chain A
residue 290
type BINDING
sequence N
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00409
source Swiss-Prot : SWS_FT_FI7

51) chain B
residue 276
type BINDING
sequence E
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00409
source Swiss-Prot : SWS_FT_FI7

52) chain B
residue 288
type BINDING
sequence E
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00409
source Swiss-Prot : SWS_FT_FI7

53) chain B
residue 290
type BINDING
sequence N
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00409
source Swiss-Prot : SWS_FT_FI7

54) chain A
residue 154-168
type prosite
sequence YPVIIKASGGGGGRG
description CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. YPVIIKASgggGGrG
source prosite : PS00866

55) chain A
residue 286-293
type prosite
sequence FIEMNTRI
description CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. FIEMNTRI
source prosite : PS00867


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