eF-site ID 2w0h-B PDB Code 2w0h Chain B click to enlarge Title X ray structure of Leishmania infantum Trypanothione reductase in complex with antimony and NADPH Classification OXIDOREDUCTASE Compound TRYPANOTHIONE REDUCTASE Source Leishmania infantum (A4HSF7_LEIIN) Sequence B:  SRAYDLVVLGAGSGGLEAGWNAAVTHKKKVAVVDVQATHG PPLFAALGGTCVNVGCVPKKLMVTGAQYMDLIRESGGFGW EMDRESLCPNWKTLIAAKNKVVNSINESYKSMFADTEGLS FHMGFGALQDAHTVVVRKSEDPHSDVLETLDTEYILIATG SWPTRLGVPGDEFCITSNEAFYLEDAPKRMLCVGGGYIAV EFAGIFNGYKPCGGYVDLCYRGDLILRGFDTEVRKSLTKQ LGANGIRVRTNLNPTKITKNEDGSNHVHFNDGTEEDYDQV MLAIGRVPRSQALQLDKAGVRTGKNGAVQVDAYSKTSVDN IYAIGDVTNRVMLTPVAINEGAAFVETVFGGKPRATDHTK VACAVFSIPPIGTCGMTEEEAAKNYETVAVYASSFTPLMH NISGSKHKEFMIRIITNESNGEVLGVHMLGDSAPEIIQSV GICMKMGAKISDFHSTIGVHPTSAEELCSMRTPAYFYESG KRVEKLS Description Functional site 1) chain B residue 461 type sequence H description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 2) chain B residue 11 type sequence G description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 3) chain B residue 13 type sequence G description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 4) chain B residue 14 type sequence S description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 5) chain B residue 15 type sequence G description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 6) chain B residue 34 type sequence V description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 7) chain B residue 35 type sequence D description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 8) chain B residue 36 type sequence V description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 9) chain B residue 46 type sequence A description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 10) chain B residue 47 type sequence A description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 11) chain B residue 50 type sequence G description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 12) chain B residue 51 type sequence T description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 13) chain B residue 52 type sequence C description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 14) chain B residue 56 type sequence G description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 15) chain B residue 57 type sequence C description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 16) chain B residue 60 type sequence K description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 17) chain B residue 126 type sequence F description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 18) chain B residue 127 type sequence G description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 19) chain B residue 159 type sequence A description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 20) chain B residue 160 type sequence T description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 21) chain B residue 161 type sequence G description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 22) chain B residue 287 type sequence R description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 23) chain B residue 290 type sequence R description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 24) chain B residue 294 type sequence L description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 25) chain B residue 326 type sequence G description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 26) chain B residue 327 type sequence D description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 27) chain B residue 333 type sequence M description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 28) chain B residue 334 type sequence L description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 29) chain B residue 335 type sequence T description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 30) chain B residue 336 type sequence P description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 31) chain B residue 461 type sequence H description BINDING SITE FOR RESIDUE SB A 1487 source : AC3 32) chain B residue 52 type sequence C description BINDING SITE FOR RESIDUE SB B 1487 source : AC4 33) chain B residue 57 type sequence C description BINDING SITE FOR RESIDUE SB B 1487 source : AC4 34) chain B residue 335 type sequence T description BINDING SITE FOR RESIDUE SB B 1487 source : AC4 35) chain B residue 60 type sequence K description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 36) chain B residue 196 type sequence G description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 37) chain B residue 197 type sequence G description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 38) chain B residue 198 type sequence Y description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 39) chain B residue 199 type sequence I description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 40) chain B residue 202 type sequence E description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 41) chain B residue 221 type sequence Y description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 42) chain B residue 222 type sequence R description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 43) chain B residue 228 type sequence R description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 44) chain B residue 254 type sequence N description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 45) chain B residue 284 type sequence A description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 46) chain B residue 285 type sequence I description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 47) chain B residue 286 type sequence G description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 48) chain B residue 287 type sequence R description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 49) chain B residue 333 type sequence M description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 50) chain B residue 334 type sequence L description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 51) chain B residue 365 type sequence A description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 52) chain B residue 37 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 1489 source : AC7 53) chain B residue 38 type sequence A description BINDING SITE FOR RESIDUE SO4 B 1489 source : AC7 54) chain B residue 39 type sequence T description BINDING SITE FOR RESIDUE SO4 B 1489 source : AC7 55) chain B residue 124 type sequence M description BINDING SITE FOR RESIDUE SO4 B 1489 source : AC7

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