eF-site ID 2w0h-AB PDB Code 2w0h Chain A, B click to enlarge Title X ray structure of Leishmania infantum Trypanothione reductase in complex with antimony and NADPH Classification OXIDOREDUCTASE Compound TRYPANOTHIONE REDUCTASE Source Leishmania infantum (A4HSF7_LEIIN) Sequence A:  SRAYDLVVLGAGSGGLEAGWNAAVTHKKKVAVVDVQATHG PPLFAALGGTCVNVGCVPKKLMVTGAQYMDLIRESGGFGW EMDRESLCPNWKTLIAAKNKVVNSINESYKSMFADTEGLS FHMGFGALQDAHTVVVRKSEDPHSDVLETLDTEYILIATG SWPTRLGVPGDEFCITSNEAFYLEDAPKRMLCVGGGYIAV EFAGIFNGYKPCGGYVDLCYRGDLILRGFDTEVRKSLTKQ LGANGIRVRTNLNPTKITKNEDGSNHVHFNDGTEEDYDQV MLAIGRVPRSQALQLDKAGVRTGKNGAVQVDAYSKTSVDN IYAIGDVTNRVMLTPVAINEGAAFVETVFGGKPRATDHTK VACAVFSIPPIGTCGMTEEEAAKNYETVAVYASSFTPLMH NISGSKHKEFMIRIITNESNGEVLGVHMLGDSAPEIIQSV GICMKMGAKISDFHSTIGVHPTSAEELCSMRTPAYFYESG KRVEK B:  SRAYDLVVLGAGSGGLEAGWNAAVTHKKKVAVVDVQATHG PPLFAALGGTCVNVGCVPKKLMVTGAQYMDLIRESGGFGW EMDRESLCPNWKTLIAAKNKVVNSINESYKSMFADTEGLS FHMGFGALQDAHTVVVRKSEDPHSDVLETLDTEYILIATG SWPTRLGVPGDEFCITSNEAFYLEDAPKRMLCVGGGYIAV EFAGIFNGYKPCGGYVDLCYRGDLILRGFDTEVRKSLTKQ LGANGIRVRTNLNPTKITKNEDGSNHVHFNDGTEEDYDQV MLAIGRVPRSQALQLDKAGVRTGKNGAVQVDAYSKTSVDN IYAIGDVTNRVMLTPVAINEGAAFVETVFGGKPRATDHTK VACAVFSIPPIGTCGMTEEEAAKNYETVAVYASSFTPLMH NISGSKHKEFMIRIITNESNGEVLGVHMLGDSAPEIIQSV GICMKMGAKISDFHSTIGVHPTSAEELCSMRTPAYFYESG KRVEKLS Description Functional site 1) chain A residue 11 type sequence G description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 2) chain A residue 13 type sequence G description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 3) chain A residue 14 type sequence S description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 4) chain A residue 15 type sequence G description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 5) chain A residue 34 type sequence V description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 6) chain A residue 35 type sequence D description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 7) chain A residue 36 type sequence V description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 8) chain A residue 46 type sequence A description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 9) chain A residue 47 type sequence A description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 10) chain A residue 50 type sequence G description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 11) chain A residue 51 type sequence T description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 12) chain A residue 52 type sequence C description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 13) chain A residue 56 type sequence G description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 14) chain A residue 57 type sequence C description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 15) chain A residue 60 type sequence K description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 16) chain A residue 126 type sequence F description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 17) chain A residue 127 type sequence G description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 18) chain A residue 159 type sequence A description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 19) chain A residue 160 type sequence T description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 20) chain A residue 161 type sequence G description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 21) chain A residue 287 type sequence R description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 22) chain A residue 290 type sequence R description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 23) chain A residue 294 type sequence L description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 24) chain A residue 326 type sequence G description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 25) chain A residue 327 type sequence D description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 26) chain A residue 333 type sequence M description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 27) chain A residue 334 type sequence L description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 28) chain A residue 335 type sequence T description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 29) chain A residue 336 type sequence P description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 30) chain B residue 461 type sequence H description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 31) chain A residue 461 type sequence H description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 32) chain B residue 11 type sequence G description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 33) chain B residue 13 type sequence G description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 34) chain B residue 14 type sequence S description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 35) chain B residue 15 type sequence G description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 36) chain B residue 34 type sequence V description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 37) chain B residue 35 type sequence D description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 38) chain B residue 36 type sequence V description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 39) chain B residue 46 type sequence A description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 40) chain B residue 47 type sequence A description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 41) chain B residue 50 type sequence G description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 42) chain B residue 51 type sequence T description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 43) chain B residue 52 type sequence C description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 44) chain B residue 56 type sequence G description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 45) chain B residue 57 type sequence C description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 46) chain B residue 60 type sequence K description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 47) chain B residue 126 type sequence F description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 48) chain B residue 127 type sequence G description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 49) chain B residue 159 type sequence A description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 50) chain B residue 160 type sequence T description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 51) chain B residue 161 type sequence G description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 52) chain B residue 287 type sequence R description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 53) chain B residue 290 type sequence R description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 54) chain B residue 294 type sequence L description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 55) chain B residue 326 type sequence G description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 56) chain B residue 327 type sequence D description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 57) chain B residue 333 type sequence M description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 58) chain B residue 334 type sequence L description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 59) chain B residue 335 type sequence T description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 60) chain B residue 336 type sequence P description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 61) chain A residue 52 type sequence C description BINDING SITE FOR RESIDUE SB A 1487 source : AC3 62) chain A residue 57 type sequence C description BINDING SITE FOR RESIDUE SB A 1487 source : AC3 63) chain A residue 335 type sequence T description BINDING SITE FOR RESIDUE SB A 1487 source : AC3 64) chain B residue 461 type sequence H description BINDING SITE FOR RESIDUE SB A 1487 source : AC3 65) chain A residue 461 type sequence H description BINDING SITE FOR RESIDUE SB B 1487 source : AC4 66) chain B residue 52 type sequence C description BINDING SITE FOR RESIDUE SB B 1487 source : AC4 67) chain B residue 57 type sequence C description BINDING SITE FOR RESIDUE SB B 1487 source : AC4 68) chain B residue 335 type sequence T description BINDING SITE FOR RESIDUE SB B 1487 source : AC4 69) chain A residue 196 type sequence G description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 70) chain A residue 197 type sequence G description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 71) chain A residue 198 type sequence Y description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 72) chain A residue 199 type sequence I description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 73) chain A residue 202 type sequence E description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 74) chain A residue 221 type sequence Y description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 75) chain A residue 222 type sequence R description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 76) chain A residue 228 type sequence R description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 77) chain A residue 254 type sequence N description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 78) chain A residue 284 type sequence A description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 79) chain A residue 285 type sequence I description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 80) chain A residue 286 type sequence G description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 81) chain A residue 333 type sequence M description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 82) chain A residue 334 type sequence L description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 83) chain A residue 365 type sequence A description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 84) chain B residue 60 type sequence K description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 85) chain B residue 196 type sequence G description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 86) chain B residue 197 type sequence G description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 87) chain B residue 198 type sequence Y description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 88) chain B residue 199 type sequence I description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 89) chain B residue 202 type sequence E description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 90) chain B residue 221 type sequence Y description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 91) chain B residue 222 type sequence R description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 92) chain B residue 228 type sequence R description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 93) chain B residue 254 type sequence N description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 94) chain B residue 284 type sequence A description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 95) chain B residue 285 type sequence I description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 96) chain B residue 286 type sequence G description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 97) chain B residue 287 type sequence R description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 98) chain B residue 333 type sequence M description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 99) chain B residue 334 type sequence L description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 100) chain B residue 365 type sequence A description BINDING SITE FOR RESIDUE NDP B 1488 source : AC6 101) chain B residue 37 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 1489 source : AC7 102) chain B residue 38 type sequence A description BINDING SITE FOR RESIDUE SO4 B 1489 source : AC7 103) chain B residue 39 type sequence T description BINDING SITE FOR RESIDUE SO4 B 1489 source : AC7 104) chain B residue 124 type sequence M description BINDING SITE FOR RESIDUE SO4 B 1489 source : AC7 105) chain A residue 37 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1489 source : AC8 106) chain A residue 38 type sequence A description BINDING SITE FOR RESIDUE SO4 A 1489 source : AC8 107) chain A residue 39 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1489 source : AC8 108) chain A residue 124 type sequence M description BINDING SITE FOR RESIDUE SO4 A 1489 source : AC8 109) chain A residue 49-59 type prosite sequence GGTCVNVGCVP description PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCVP source prosite : PS00076

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