eF-site ID 2w0h-A PDB Code 2w0h Chain A click to enlarge Title X ray structure of Leishmania infantum Trypanothione reductase in complex with antimony and NADPH Classification OXIDOREDUCTASE Compound TRYPANOTHIONE REDUCTASE Source Leishmania infantum (A4HSF7_LEIIN) Sequence A:  SRAYDLVVLGAGSGGLEAGWNAAVTHKKKVAVVDVQATHG PPLFAALGGTCVNVGCVPKKLMVTGAQYMDLIRESGGFGW EMDRESLCPNWKTLIAAKNKVVNSINESYKSMFADTEGLS FHMGFGALQDAHTVVVRKSEDPHSDVLETLDTEYILIATG SWPTRLGVPGDEFCITSNEAFYLEDAPKRMLCVGGGYIAV EFAGIFNGYKPCGGYVDLCYRGDLILRGFDTEVRKSLTKQ LGANGIRVRTNLNPTKITKNEDGSNHVHFNDGTEEDYDQV MLAIGRVPRSQALQLDKAGVRTGKNGAVQVDAYSKTSVDN IYAIGDVTNRVMLTPVAINEGAAFVETVFGGKPRATDHTK VACAVFSIPPIGTCGMTEEEAAKNYETVAVYASSFTPLMH NISGSKHKEFMIRIITNESNGEVLGVHMLGDSAPEIIQSV GICMKMGAKISDFHSTIGVHPTSAEELCSMRTPAYFYESG KRVEK Description Functional site 1) chain A residue 11 type sequence G description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 2) chain A residue 13 type sequence G description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 3) chain A residue 14 type sequence S description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 4) chain A residue 15 type sequence G description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 5) chain A residue 34 type sequence V description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 6) chain A residue 35 type sequence D description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 7) chain A residue 36 type sequence V description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 8) chain A residue 46 type sequence A description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 9) chain A residue 47 type sequence A description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 10) chain A residue 50 type sequence G description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 11) chain A residue 51 type sequence T description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 12) chain A residue 52 type sequence C description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 13) chain A residue 56 type sequence G description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 14) chain A residue 57 type sequence C description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 15) chain A residue 60 type sequence K description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 16) chain A residue 126 type sequence F description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 17) chain A residue 127 type sequence G description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 18) chain A residue 159 type sequence A description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 19) chain A residue 160 type sequence T description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 20) chain A residue 161 type sequence G description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 21) chain A residue 287 type sequence R description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 22) chain A residue 290 type sequence R description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 23) chain A residue 294 type sequence L description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 24) chain A residue 326 type sequence G description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 25) chain A residue 327 type sequence D description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 26) chain A residue 333 type sequence M description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 27) chain A residue 334 type sequence L description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 28) chain A residue 335 type sequence T description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 29) chain A residue 336 type sequence P description BINDING SITE FOR RESIDUE FAD A 1486 source : AC1 30) chain A residue 461 type sequence H description BINDING SITE FOR RESIDUE FAD B 1486 source : AC2 31) chain A residue 52 type sequence C description BINDING SITE FOR RESIDUE SB A 1487 source : AC3 32) chain A residue 57 type sequence C description BINDING SITE FOR RESIDUE SB A 1487 source : AC3 33) chain A residue 335 type sequence T description BINDING SITE FOR RESIDUE SB A 1487 source : AC3 34) chain A residue 461 type sequence H description BINDING SITE FOR RESIDUE SB B 1487 source : AC4 35) chain A residue 196 type sequence G description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 36) chain A residue 197 type sequence G description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 37) chain A residue 198 type sequence Y description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 38) chain A residue 199 type sequence I description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 39) chain A residue 202 type sequence E description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 40) chain A residue 221 type sequence Y description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 41) chain A residue 222 type sequence R description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 42) chain A residue 228 type sequence R description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 43) chain A residue 254 type sequence N description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 44) chain A residue 284 type sequence A description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 45) chain A residue 285 type sequence I description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 46) chain A residue 286 type sequence G description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 47) chain A residue 333 type sequence M description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 48) chain A residue 334 type sequence L description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 49) chain A residue 365 type sequence A description BINDING SITE FOR RESIDUE NDP A 1488 source : AC5 50) chain A residue 37 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1489 source : AC8 51) chain A residue 38 type sequence A description BINDING SITE FOR RESIDUE SO4 A 1489 source : AC8 52) chain A residue 39 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1489 source : AC8 53) chain A residue 124 type sequence M description BINDING SITE FOR RESIDUE SO4 A 1489 source : AC8 54) chain A residue 49-59 type prosite sequence GGTCVNVGCVP description PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCVP source prosite : PS00076

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