eF-site ID 2vwu-A PDB Code 2vwu Chain A click to enlarge Title ephB4 kinase domain inhibitor complex Classification TRANSFERASE Compound EPHRIN TYPE-B RECEPTOR 4 Source (EPHB4_HUMAN) Sequence A:  EIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKT LTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMIL TEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLA EMSYVHRDLAARNILVNSNLVCKVSDFIPIRWTAPEAIAF RKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIE QDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSAL DKMIRNPASLKIV Description Functional site 1) chain A residue 621 type sequence I description BINDING SITE FOR RESIDUE 7X1 A1888 source : AC1 2) chain A residue 645 type sequence A description BINDING SITE FOR RESIDUE 7X1 A1888 source : AC1 3) chain A residue 647 type sequence K description BINDING SITE FOR RESIDUE 7X1 A1888 source : AC1 4) chain A residue 664 type sequence E description BINDING SITE FOR RESIDUE 7X1 A1888 source : AC1 5) chain A residue 677 type sequence I description BINDING SITE FOR RESIDUE 7X1 A1888 source : AC1 6) chain A residue 691 type sequence I description BINDING SITE FOR RESIDUE 7X1 A1888 source : AC1 7) chain A residue 693 type sequence T description BINDING SITE FOR RESIDUE 7X1 A1888 source : AC1 8) chain A residue 694 type sequence E description BINDING SITE FOR RESIDUE 7X1 A1888 source : AC1 9) chain A residue 696 type sequence M description BINDING SITE FOR RESIDUE 7X1 A1888 source : AC1 10) chain A residue 697 type sequence E description BINDING SITE FOR RESIDUE 7X1 A1888 source : AC1 11) chain A residue 699 type sequence G description BINDING SITE FOR RESIDUE 7X1 A1888 source : AC1 12) chain A residue 747 type sequence L description BINDING SITE FOR RESIDUE 7X1 A1888 source : AC1 13) chain A residue 757 type sequence S description BINDING SITE FOR RESIDUE 7X1 A1888 source : AC1 14) chain A residue 621-647 type prosite sequence IGAGEFGEVCRGRLKAPGKKESCVAIK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGAGEFGEVCrGrlkapgkkesc.......VAIK source prosite : PS00107 15) chain A residue 736-748 type prosite sequence YVHRDLAARNILV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLAARNILV source prosite : PS00109 16) chain A residue 740 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 621 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 647 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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