eF-site ID 2vwn-A
PDB Code 2vwn
Chain A

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Title Aminopyrrolidine Factor Xa inhibitor
Classification BLOOD CLOTTING
Compound ACTIVATED FACTOR XA HEAVY CHAIN
Source Homo sapiens (Human) (FA10_HUMAN)
Sequence A:  IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTA
AHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRF
TKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLM
TQKTGIVSGFGRTHEKGEQSTRLKMLEVPYVDRNSCKLSS
SFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVT
GIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTR
Description


Functional site

1) chain A
residue 97
type
sequence E
description BINDING SITE FOR RESIDUE H25 A 1245
source : AC1

2) chain A
residue 98
type
sequence T
description BINDING SITE FOR RESIDUE H25 A 1245
source : AC1

3) chain A
residue 99
type
sequence Y
description BINDING SITE FOR RESIDUE H25 A 1245
source : AC1

4) chain A
residue 166
type
sequence N
description BINDING SITE FOR RESIDUE H25 A 1245
source : AC1

5) chain A
residue 169
type
sequence K
description BINDING SITE FOR RESIDUE H25 A 1245
source : AC1

6) chain A
residue 174
type
sequence F
description BINDING SITE FOR RESIDUE H25 A 1245
source : AC1

7) chain A
residue 189
type
sequence D
description BINDING SITE FOR RESIDUE H25 A 1245
source : AC1

8) chain A
residue 190
type
sequence A
description BINDING SITE FOR RESIDUE H25 A 1245
source : AC1

9) chain A
residue 191
type
sequence C
description BINDING SITE FOR RESIDUE H25 A 1245
source : AC1

10) chain A
residue 192
type
sequence Q
description BINDING SITE FOR RESIDUE H25 A 1245
source : AC1

11) chain A
residue 213
type
sequence V
description BINDING SITE FOR RESIDUE H25 A 1245
source : AC1

12) chain A
residue 215
type
sequence W
description BINDING SITE FOR RESIDUE H25 A 1245
source : AC1

13) chain A
residue 216
type
sequence G
description BINDING SITE FOR RESIDUE H25 A 1245
source : AC1

14) chain A
residue 218
type
sequence G
description BINDING SITE FOR RESIDUE H25 A 1245
source : AC1

15) chain A
residue 220
type
sequence C
description BINDING SITE FOR RESIDUE H25 A 1245
source : AC1

16) chain A
residue 226
type
sequence G
description BINDING SITE FOR RESIDUE H25 A 1245
source : AC1

17) chain A
residue 227
type
sequence I
description BINDING SITE FOR RESIDUE H25 A 1245
source : AC1

18) chain A
residue 228
type
sequence Y
description BINDING SITE FOR RESIDUE H25 A 1245
source : AC1

19) chain A
residue 70
type
sequence D
description BINDING SITE FOR RESIDUE CA A 1246
source : AC2

20) chain A
residue 72
type
sequence N
description BINDING SITE FOR RESIDUE CA A 1246
source : AC2

21) chain A
residue 75
type
sequence Q
description BINDING SITE FOR RESIDUE CA A 1246
source : AC2

22) chain A
residue 80
type
sequence E
description BINDING SITE FOR RESIDUE CA A 1246
source : AC2

23) chain A
residue 185
type
sequence Y
description BINDING SITE FOR RESIDUE NA A 1247
source : AC3

24) chain A
residue 185
type
sequence Y
description BINDING SITE FOR RESIDUE NA A 1247
source : AC3

25) chain A
residue 222
type
sequence R
description BINDING SITE FOR RESIDUE NA A 1247
source : AC3

26) chain A
residue 224
type
sequence K
description BINDING SITE FOR RESIDUE NA A 1247
source : AC3

27) chain A
residue 166
type
sequence N
description BINDING SITE FOR RESIDUE CL A 1248
source : AC4

28) chain A
residue 218
type
sequence G
description BINDING SITE FOR RESIDUE CL A 1248
source : AC4

29) chain A
residue 96
type
sequence K
description BINDING SITE FOR RESIDUE CL A 1249
source : AC5

30) chain A
residue 177
type
sequence T
description BINDING SITE FOR RESIDUE CL A 1249
source : AC5

31) chain A
residue 178
type
sequence Q
description BINDING SITE FOR RESIDUE CL A 1249
source : AC5

32) chain A
residue 53-58
type prosite
sequence LTAAHC
description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
source prosite : PS00134

33) chain A
residue 189-200
type prosite
sequence DACQGDSGGPHV
description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAcqGDSGGPHV
source prosite : PS00135

34) chain A
residue 57
type ACT_SITE
sequence H
description Charge relay system
source Swiss-Prot : SWS_FT_FI1

35) chain A
residue 102
type ACT_SITE
sequence D
description Charge relay system
source Swiss-Prot : SWS_FT_FI1

36) chain A
residue 195
type ACT_SITE
sequence S
description Charge relay system
source Swiss-Prot : SWS_FT_FI1


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