eF-site ID 2vvc-ABKL PDB Code 2vvc Chain A, B, K, L click to enlarge Title Aminopyrrolidine Factor Xa inhibitor Classification HYDROLASE Compound ACTIVATED FACTOR XA HEAVY CHAIN Source Homo sapiens (Human) (FA10_HUMAN) Sequence A:  IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTA AHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRF TKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLM TQKTGIVSGFGRTHEKGEQSTRLKMLEVPYVDRNSCKLSS SFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVT GIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMK B:  IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTA AHCLYQAKRFKVRVGGGEAVHEVEVVIKHNRFTKETYDFD IAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVS GFGRTHEKGEQSTRLKMLEVPYVDRNSCKLSSSFIITQNM FCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEG CARKGKYGIYTKVTAFLKWIDRSMK K:  RKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACI PTGPYPCGKQTLER L:  KLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIP TGPYPCGKQTLE Description Functional site 1) chain A residue 97 type sequence E description BINDING SITE FOR RESIDUE LZF A 1244 source : AC1 2) chain A residue 98 type sequence T description BINDING SITE FOR RESIDUE LZF A 1244 source : AC1 3) chain A residue 99 type sequence Y description BINDING SITE FOR RESIDUE LZF A 1244 source : AC1 4) chain A residue 147 type sequence E description BINDING SITE FOR RESIDUE LZF A 1244 source : AC1 5) chain A residue 174 type sequence F description BINDING SITE FOR RESIDUE LZF A 1244 source : AC1 6) chain A residue 189 type sequence D description BINDING SITE FOR RESIDUE LZF A 1244 source : AC1 7) chain A residue 190 type sequence A description BINDING SITE FOR RESIDUE LZF A 1244 source : AC1 8) chain A residue 192 type sequence Q description BINDING SITE FOR RESIDUE LZF A 1244 source : AC1 9) chain A residue 213 type sequence V description BINDING SITE FOR RESIDUE LZF A 1244 source : AC1 10) chain A residue 215 type sequence W description BINDING SITE FOR RESIDUE LZF A 1244 source : AC1 11) chain A residue 216 type sequence G description BINDING SITE FOR RESIDUE LZF A 1244 source : AC1 12) chain A residue 218 type sequence G description BINDING SITE FOR RESIDUE LZF A 1244 source : AC1 13) chain A residue 220 type sequence C description BINDING SITE FOR RESIDUE LZF A 1244 source : AC1 14) chain A residue 226 type sequence G description BINDING SITE FOR RESIDUE LZF A 1244 source : AC1 15) chain A residue 227 type sequence I description BINDING SITE FOR RESIDUE LZF A 1244 source : AC1 16) chain A residue 228 type sequence Y description BINDING SITE FOR RESIDUE LZF A 1244 source : AC1 17) chain B residue 97 type sequence E description BINDING SITE FOR RESIDUE LZF B 1244 source : AC2 18) chain B residue 98 type sequence T description BINDING SITE FOR RESIDUE LZF B 1244 source : AC2 19) chain B residue 147 type sequence E description BINDING SITE FOR RESIDUE LZF B 1244 source : AC2 20) chain B residue 174 type sequence F description BINDING SITE FOR RESIDUE LZF B 1244 source : AC2 21) chain B residue 189 type sequence D description BINDING SITE FOR RESIDUE LZF B 1244 source : AC2 22) chain B residue 190 type sequence A description BINDING SITE FOR RESIDUE LZF B 1244 source : AC2 23) chain B residue 192 type sequence Q description BINDING SITE FOR RESIDUE LZF B 1244 source : AC2 24) chain B residue 195 type sequence S description BINDING SITE FOR RESIDUE LZF B 1244 source : AC2 25) chain B residue 213 type sequence V description BINDING SITE FOR RESIDUE LZF B 1244 source : AC2 26) chain B residue 215 type sequence W description BINDING SITE FOR RESIDUE LZF B 1244 source : AC2 27) chain B residue 216 type sequence G description BINDING SITE FOR RESIDUE LZF B 1244 source : AC2 28) chain B residue 217 type sequence E description BINDING SITE FOR RESIDUE LZF B 1244 source : AC2 29) chain B residue 218 type sequence G description BINDING SITE FOR RESIDUE LZF B 1244 source : AC2 30) chain B residue 220 type sequence C description BINDING SITE FOR RESIDUE LZF B 1244 source : AC2 31) chain B residue 226 type sequence G description BINDING SITE FOR RESIDUE LZF B 1244 source : AC2 32) chain B residue 227 type sequence I description BINDING SITE FOR RESIDUE LZF B 1244 source : AC2 33) chain B residue 228 type sequence Y description BINDING SITE FOR RESIDUE LZF B 1244 source : AC2 34) chain A residue 70 type sequence D description BINDING SITE FOR RESIDUE CA A 1245 source : AC3 35) chain A residue 72 type sequence N description BINDING SITE FOR RESIDUE CA A 1245 source : AC3 36) chain A residue 75 type sequence Q description BINDING SITE FOR RESIDUE CA A 1245 source : AC3 37) chain A residue 76 type sequence E description BINDING SITE FOR RESIDUE CA A 1245 source : AC3 38) chain A residue 77 type sequence E description BINDING SITE FOR RESIDUE CA A 1245 source : AC3 39) chain A residue 80 type sequence E description BINDING SITE FOR RESIDUE CA A 1245 source : AC3 40) chain A residue 185 type sequence Y description BINDING SITE FOR RESIDUE NA A 1246 source : AC4 41) chain A residue 185 type sequence Y description BINDING SITE FOR RESIDUE NA A 1246 source : AC4 42) chain A residue 222 type sequence R description BINDING SITE FOR RESIDUE NA A 1246 source : AC4 43) chain A residue 224 type sequence K description BINDING SITE FOR RESIDUE NA A 1246 source : AC4 44) chain B residue 185 type sequence Y description BINDING SITE FOR RESIDUE NA B 1245 source : AC5 45) chain B residue 185 type sequence Y description BINDING SITE FOR RESIDUE NA B 1245 source : AC5 46) chain B residue 222 type sequence R description BINDING SITE FOR RESIDUE NA B 1245 source : AC5 47) chain B residue 224 type sequence K description BINDING SITE FOR RESIDUE NA B 1245 source : AC5 48) chain A residue 57 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI1 49) chain A residue 102 type ACT_SITE sequence D description Charge relay system source Swiss-Prot : SWS_FT_FI1 50) chain A residue 195 type ACT_SITE sequence S description Charge relay system source Swiss-Prot : SWS_FT_FI1 51) chain B residue 57 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI1 52) chain B residue 102 type ACT_SITE sequence D description Charge relay system source Swiss-Prot : SWS_FT_FI1 53) chain B residue 195 type ACT_SITE sequence S description Charge relay system source Swiss-Prot : SWS_FT_FI1 54) chain K residue 109-124 type prosite sequence CSCARGYTLADNGKAC description EGF_2 EGF-like domain signature 2. CsCarGYtladngkaC source prosite : PS01186 55) chain A residue 53-58 type prosite sequence LTAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC source prosite : PS00134 56) chain A residue 189-200 type prosite sequence DACQGDSGGPHV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAcqGDSGGPHV source prosite : PS00135

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