eF-site ID 2vv5-ABCDEFG
PDB Code 2vv5
Chain A, B, C, D, E, F, G

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Title The open structure of MscS
Classification MEMBRANE PROTEIN
Compound SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL
Source Escherichia coli O157:H7 (MSCS_ECO57)
Sequence A:  LSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDAT
VADFLSALVRYGIIAFTLIAALGRVGVQTASVIAVLGAAG
LVVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGT
VLSVQIFSTTMRTADGKIIVIPNGKIIAGNIINFSREPVR
RNEFIIGVAYDSDIDQVKQILTNIIQSEDRILKDREMTVR
LNELGASSINFVVRVWSNSGDLQNVYWDVLERIKREFDAA
GISFPYPQMDVNFKRVK
B:  LSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDAT
VADFLSALVRYGIIAFTLIAALGRVGVQTASVIAVLGAAG
LVVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGT
VLSVQIFSTTMRTADGKIIVIPNGKIIAGNIINFSREPVR
RNEFIIGVAYDSDIDQVKQILTNIIQSEDRILKDREMTVR
LNELGASSINFVVRVWSNSGDLQNVYWDVLERIKREFDAA
GISFPYPQMDVNFKRVK
C:  LSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDAT
VADFLSALVRYGIIAFTLIAALGRVGVQTASVIAVLGAAG
LVVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGT
VLSVQIFSTTMRTADGKIIVIPNGKIIAGNIINFSREPVR
RNEFIIGVAYDSDIDQVKQILTNIIQSEDRILKDREMTVR
LNELGASSINFVVRVWSNSGDLQNVYWDVLERIKREFDAA
GISFPYPQMDVNFKRVK
D:  LSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDAT
VADFLSALVRYGIIAFTLIAALGRVGVQTASVIAVLGAAG
LVVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGT
VLSVQIFSTTMRTADGKIIVIPNGKIIAGNIINFSREPVR
RNEFIIGVAYDSDIDQVKQILTNIIQSEDRILKDREMTVR
LNELGASSINFVVRVWSNSGDLQNVYWDVLERIKREFDAA
GISFPYPQMDVNFKRVK
E:  LSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDAT
VADFLSALVRYGIIAFTLIAALGRVGVQTASVIAVLGAAG
LVVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGT
VLSVQIFSTTMRTADGKIIVIPNGKIIAGNIINFSREPVR
RNEFIIGVAYDSDIDQVKQILTNIIQSEDRILKDREMTVR
LNELGASSINFVVRVWSNSGDLQNVYWDVLERIKREFDAA
GISFPYPQMDVNFKRVK
F:  LSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDAT
VADFLSALVRYGIIAFTLIAALGRVGVQTASVIAVLGAAG
LVVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGT
VLSVQIFSTTMRTADGKIIVIPNGKIIAGNIINFSREPVR
RNEFIIGVAYDSDIDQVKQILTNIIQSEDRILKDREMTVR
LNELGASSINFVVRVWSNSGDLQNVYWDVLERIKREFDAA
GISFPYPQMDVNFKRVK
G:  LSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDAT
VADFLSALVRYGIIAFTLIAALGRVGVQTASVIAVLGAAG
LVVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGT
VLSVQIFSTTMRTADGKIIVIPNGKIIAGNIINFSREPVR
RNEFIIGVAYDSDIDQVKQILTNIIQSEDRILKDREMTVR
LNELGASSINFVVRVWSNSGDLQNVYWDVLERIKREFDAA
GISFPYPQMDVNFKRVK
Description


Functional site
1) chain E
residue 89-90
type TOPO_DOM
sequence VG
description Periplasmic => ECO:0000305|PubMed:15919996
source Swiss-Prot : SWS_FT_FI1
2) chain F
residue 89-90
type TOPO_DOM
sequence VG
description Periplasmic => ECO:0000305|PubMed:15919996
source Swiss-Prot : SWS_FT_FI1
3) chain G
residue 89-90
type TOPO_DOM
sequence VG
description Periplasmic => ECO:0000305|PubMed:15919996
source Swiss-Prot : SWS_FT_FI1
4) chain A
residue 89-90
type TOPO_DOM
sequence VG
description Periplasmic => ECO:0000305|PubMed:15919996
source Swiss-Prot : SWS_FT_FI1
5) chain B
residue 89-90
type TOPO_DOM
sequence VG
description Periplasmic => ECO:0000305|PubMed:15919996
source Swiss-Prot : SWS_FT_FI1
6) chain C
residue 89-90
type TOPO_DOM
sequence VG
description Periplasmic => ECO:0000305|PubMed:15919996
source Swiss-Prot : SWS_FT_FI1
7) chain D
residue 89-90
type TOPO_DOM
sequence VG
description Periplasmic => ECO:0000305|PubMed:15919996
source Swiss-Prot : SWS_FT_FI1
8) chain A
residue 31-52
type TRANSMEM
sequence IVAALAIIIVGLIIARMISNAV
description Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
source Swiss-Prot : SWS_FT_FI2
9) chain D
residue 31-52
type TRANSMEM
sequence IVAALAIIIVGLIIARMISNAV
description Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
source Swiss-Prot : SWS_FT_FI2
10) chain D
residue 68-88
type TRANSMEM
sequence FLSALVRYGIIAFTLIAALGR
description Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
source Swiss-Prot : SWS_FT_FI2
11) chain D
residue 91-111
type TRANSMEM
sequence VQTASVIAVLGAAGLVVGLAL
description Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
source Swiss-Prot : SWS_FT_FI2
12) chain E
residue 31-52
type TRANSMEM
sequence IVAALAIIIVGLIIARMISNAV
description Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
source Swiss-Prot : SWS_FT_FI2
13) chain E
residue 68-88
type TRANSMEM
sequence FLSALVRYGIIAFTLIAALGR
description Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
source Swiss-Prot : SWS_FT_FI2
14) chain E
residue 91-111
type TRANSMEM
sequence VQTASVIAVLGAAGLVVGLAL
description Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
source Swiss-Prot : SWS_FT_FI2
15) chain F
residue 31-52
type TRANSMEM
sequence IVAALAIIIVGLIIARMISNAV
description Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
source Swiss-Prot : SWS_FT_FI2
16) chain F
residue 68-88
type TRANSMEM
sequence FLSALVRYGIIAFTLIAALGR
description Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
source Swiss-Prot : SWS_FT_FI2
17) chain F
residue 91-111
type TRANSMEM
sequence VQTASVIAVLGAAGLVVGLAL
description Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
source Swiss-Prot : SWS_FT_FI2
18) chain G
residue 31-52
type TRANSMEM
sequence IVAALAIIIVGLIIARMISNAV
description Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
source Swiss-Prot : SWS_FT_FI2
19) chain A
residue 68-88
type TRANSMEM
sequence FLSALVRYGIIAFTLIAALGR
description Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
source Swiss-Prot : SWS_FT_FI2
20) chain G
residue 68-88
type TRANSMEM
sequence FLSALVRYGIIAFTLIAALGR
description Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
source Swiss-Prot : SWS_FT_FI2
21) chain G
residue 91-111
type TRANSMEM
sequence VQTASVIAVLGAAGLVVGLAL
description Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
source Swiss-Prot : SWS_FT_FI2
22) chain A
residue 91-111
type TRANSMEM
sequence VQTASVIAVLGAAGLVVGLAL
description Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
source Swiss-Prot : SWS_FT_FI2
23) chain B
residue 31-52
type TRANSMEM
sequence IVAALAIIIVGLIIARMISNAV
description Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
source Swiss-Prot : SWS_FT_FI2
24) chain B
residue 68-88
type TRANSMEM
sequence FLSALVRYGIIAFTLIAALGR
description Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
source Swiss-Prot : SWS_FT_FI2
25) chain B
residue 91-111
type TRANSMEM
sequence VQTASVIAVLGAAGLVVGLAL
description Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
source Swiss-Prot : SWS_FT_FI2
26) chain C
residue 31-52
type TRANSMEM
sequence IVAALAIIIVGLIIARMISNAV
description Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
source Swiss-Prot : SWS_FT_FI2
27) chain C
residue 68-88
type TRANSMEM
sequence FLSALVRYGIIAFTLIAALGR
description Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
source Swiss-Prot : SWS_FT_FI2
28) chain C
residue 91-111
type TRANSMEM
sequence VQTASVIAVLGAAGLVVGLAL
description Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
source Swiss-Prot : SWS_FT_FI2
29) chain A
residue 53-67
type TOPO_DOM
sequence NRLMISRKIDATVAD
description Cytoplasmic => ECO:0000305|PubMed:15919996
source Swiss-Prot : SWS_FT_FI3
30) chain F
residue 53-67
type TOPO_DOM
sequence NRLMISRKIDATVAD
description Cytoplasmic => ECO:0000305|PubMed:15919996
source Swiss-Prot : SWS_FT_FI3
31) chain G
residue 53-67
type TOPO_DOM
sequence NRLMISRKIDATVAD
description Cytoplasmic => ECO:0000305|PubMed:15919996
source Swiss-Prot : SWS_FT_FI3
32) chain B
residue 53-67
type TOPO_DOM
sequence NRLMISRKIDATVAD
description Cytoplasmic => ECO:0000305|PubMed:15919996
source Swiss-Prot : SWS_FT_FI3
33) chain C
residue 53-67
type TOPO_DOM
sequence NRLMISRKIDATVAD
description Cytoplasmic => ECO:0000305|PubMed:15919996
source Swiss-Prot : SWS_FT_FI3
34) chain D
residue 53-67
type TOPO_DOM
sequence NRLMISRKIDATVAD
description Cytoplasmic => ECO:0000305|PubMed:15919996
source Swiss-Prot : SWS_FT_FI3
35) chain E
residue 53-67
type TOPO_DOM
sequence NRLMISRKIDATVAD
description Cytoplasmic => ECO:0000305|PubMed:15919996
source Swiss-Prot : SWS_FT_FI3
36) chain A
residue 143-177
type prosite
sequence GTVLSVQIFSTTMRTADGKIIVIPNGKIIAGNIIN
description UPF0003 Uncharacterized protein family UPF0003 signature. GTVlsVqifsttMrtaDgkiIvIPNgkIIagniiN
source prosite : PS01246

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