eF-site ID 2vv2-AB PDB Code 2vv2 Chain A, B click to enlarge Title hPPARgamma Ligand binding domain in complex with 5-HEPA Classification RECEPTOR Compound PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA Source (PPARG_HUMAN) Sequence A:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGTTDKSPF VIYDMNSLMMGEDKIKKEVAIRIFQGCQFRSVEAVQEITE YAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDG VLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALE LDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALE LQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKK TETDMSLHPLLQEIYK B:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKDKSPFV IYDMNSLMMGEDKIKFKHITPLKEVAIRIFQGCQFRSVEA VQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAV KFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDN LLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL LQVIKKTETPLLQEIYK Description Functional site 1) chain A residue 281 type sequence I description BINDING SITE FOR RESIDUE 5HE A 1476 source : AC1 2) chain A residue 285 type sequence C description BINDING SITE FOR RESIDUE 5HE A 1476 source : AC1 3) chain A residue 289 type sequence S description BINDING SITE FOR RESIDUE 5HE A 1476 source : AC1 4) chain A residue 323 type sequence H description BINDING SITE FOR RESIDUE 5HE A 1476 source : AC1 5) chain A residue 327 type sequence Y description BINDING SITE FOR RESIDUE 5HE A 1476 source : AC1 6) chain A residue 330 type sequence L description BINDING SITE FOR RESIDUE 5HE A 1476 source : AC1 7) chain A residue 342 type sequence S description BINDING SITE FOR RESIDUE 5HE A 1476 source : AC1 8) chain A residue 363 type sequence F description BINDING SITE FOR RESIDUE 5HE A 1476 source : AC1 9) chain A residue 364 type sequence M description BINDING SITE FOR RESIDUE 5HE A 1476 source : AC1 10) chain A residue 449 type sequence H description BINDING SITE FOR RESIDUE 5HE A 1476 source : AC1 11) chain A residue 453 type sequence L description BINDING SITE FOR RESIDUE 5HE A 1476 source : AC1 12) chain A residue 473 type sequence Y description BINDING SITE FOR RESIDUE 5HE A 1476 source : AC1 13) chain B residue 281 type sequence I description BINDING SITE FOR RESIDUE 5HE B 1476 source : AC2 14) chain B residue 285 type sequence C description BINDING SITE FOR RESIDUE 5HE B 1476 source : AC2 15) chain B residue 288 type sequence R description BINDING SITE FOR RESIDUE 5HE B 1476 source : AC2 16) chain B residue 291 type sequence E description BINDING SITE FOR RESIDUE 5HE B 1476 source : AC2 17) chain B residue 333 type sequence L description BINDING SITE FOR RESIDUE 5HE B 1476 source : AC2 18) chain B residue 340 type sequence L description BINDING SITE FOR RESIDUE 5HE B 1476 source : AC2 19) chain B residue 342 type sequence S description BINDING SITE FOR RESIDUE 5HE B 1476 source : AC2 20) chain B residue 343 type sequence E description BINDING SITE FOR RESIDUE 5HE B 1476 source : AC2 21) chain B residue 364 type sequence M description BINDING SITE FOR RESIDUE 5HE B 1476 source : AC2 22) chain B residue 228 type sequence L description BINDING SITE FOR RESIDUE 5HE B 1477 source : AC3 23) chain B residue 282 type sequence F description BINDING SITE FOR RESIDUE 5HE B 1477 source : AC3 24) chain B residue 285 type sequence C description BINDING SITE FOR RESIDUE 5HE B 1477 source : AC3 25) chain B residue 288 type sequence R description BINDING SITE FOR RESIDUE 5HE B 1477 source : AC3 26) chain B residue 295 type sequence E description BINDING SITE FOR RESIDUE 5HE B 1477 source : AC3 27) chain B residue 326 type sequence I description BINDING SITE FOR RESIDUE 5HE B 1477 source : AC3 28) chain B residue 329 type sequence M description BINDING SITE FOR RESIDUE 5HE B 1477 source : AC3 29) chain B residue 333 type sequence L description BINDING SITE FOR RESIDUE 5HE B 1477 source : AC3 30) chain B residue 363 type sequence F description BINDING SITE FOR RESIDUE 5HE B 1477 source : AC3 31) chain A residue 316 type BINDING sequence T description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 32) chain A residue 353 type BINDING sequence L description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 33) chain B residue 316 type BINDING sequence T description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 34) chain B residue 353 type BINDING sequence L description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 35) chain A residue 254 type CROSSLNK sequence S description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2 36) chain B residue 254 type CROSSLNK sequence S description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

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