eF-site ID 2vv1-AB PDB Code 2vv1 Chain A, B click to enlarge Title hPPARgamma Ligand binding domain in complex with 4-HDHA Classification RECEPTOR Compound PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA Source (PPARG_HUMAN) Sequence A:  PESADLRALAKHLYDSYIKSFPLTKAKARAILTGTTDKSP FVIYDMNSLMMGEDKIEVAIRIFQGCQFRSVEAVQEITEY AKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGV LISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALEL DDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALEL QLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKT ETDMSLHPLLQEIYKD B:  SDLRALAKHLYDSYIKSFPLTKAKARAILTGKDKSPFVIY DMNSLMMGEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFV NLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGF MTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIF IAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPE SSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTPLLQEIY Description Functional site 1) chain A residue 282 type sequence F description BINDING SITE FOR RESIDUE 4HD A 1476 source : AC1 2) chain A residue 285 type sequence C description BINDING SITE FOR RESIDUE 4HD A 1476 source : AC1 3) chain A residue 286 type sequence Q description BINDING SITE FOR RESIDUE 4HD A 1476 source : AC1 4) chain A residue 289 type sequence S description BINDING SITE FOR RESIDUE 4HD A 1476 source : AC1 5) chain A residue 323 type sequence H description BINDING SITE FOR RESIDUE 4HD A 1476 source : AC1 6) chain A residue 330 type sequence L description BINDING SITE FOR RESIDUE 4HD A 1476 source : AC1 7) chain A residue 364 type sequence M description BINDING SITE FOR RESIDUE 4HD A 1476 source : AC1 8) chain A residue 449 type sequence H description BINDING SITE FOR RESIDUE 4HD A 1476 source : AC1 9) chain A residue 469 type sequence L description BINDING SITE FOR RESIDUE 4HD A 1476 source : AC1 10) chain A residue 473 type sequence Y description BINDING SITE FOR RESIDUE 4HD A 1476 source : AC1 11) chain B residue 285 type sequence C description BINDING SITE FOR RESIDUE 4HD B 1474 source : AC2 12) chain B residue 288 type sequence R description BINDING SITE FOR RESIDUE 4HD B 1474 source : AC2 13) chain B residue 289 type sequence S description BINDING SITE FOR RESIDUE 4HD B 1474 source : AC2 14) chain B residue 291 type sequence E description BINDING SITE FOR RESIDUE 4HD B 1474 source : AC2 15) chain B residue 326 type sequence I description BINDING SITE FOR RESIDUE 4HD B 1474 source : AC2 16) chain B residue 330 type sequence L description BINDING SITE FOR RESIDUE 4HD B 1474 source : AC2 17) chain B residue 339 type sequence V description BINDING SITE FOR RESIDUE 4HD B 1474 source : AC2 18) chain B residue 342 type sequence S description BINDING SITE FOR RESIDUE 4HD B 1474 source : AC2 19) chain B residue 364 type sequence M description BINDING SITE FOR RESIDUE 4HD B 1474 source : AC2 20) chain B residue 316 type BINDING sequence T description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 21) chain B residue 353 type BINDING sequence L description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 22) chain B residue 254 type CROSSLNK sequence S description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

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