eF-site ID 2vum-B PDB Code 2vum Chain B click to enlarge Title Alpha-amanitin inhibited complete RNA polymerase II elongation complex Classification TRANSFERASE Compound DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 Source ORGANISM_COMMON: BAKERS' YEAST; ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE; Sequence B:  DESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYTL QDIICEDSTLIISFGKIYVTKPMVNESDGVTHALYPQEAR LRNLTYSSGLFVDVKKKVFIGRLPIMLRSKNCYLSEATES DLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFK KAAPSPISHVAEIRSALEKGSRFISTLQVKLYGREGSSAR TIKATLPYIKQDIPIVIIFRALGIIPDGEILEHICYDVND WQMLEMLKPCVEDGFVIQDRETALDFIGKEKRIQYAKDIL QKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQD DRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTV ELAINAKTITSGLKYALATGNWGEQKKAMSSRAGVSQVLN RYTYSSTLSHLRRTNTPIAKPRQLHNTHWGLVCPAETPEG QACGLVKNLSLMSCISVGTDPMPIITFLSEWGMEPLEDYV PHQSPDATRVFVNGVWHGVHRNPARLMETLRTLRRKGDIN PEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDESLGHKE LKVRKGHIAKLMATEYQDEYTWSSLLNEGLVEYIDAEEEE SILIAMQPEDLEPAEADVDPAKRIRVSHHATTFTHCEIHP SMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNY NVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIV AIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKK YGMSITETFEKPQRTNTLRMKHGTYDKLDDDGLIAPGVRV SGEDVIIGKTTPISSKRDASTPLRSTENGIVDQVLVTTNQ DGLKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRRED MPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALS GNEGDASPFTDITVEGISKLLREHGYQSRGFEVMYNGHTG KKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQP VEGRSRDGGLRFGEMERDCMIAHGAASFLKERLMEASDAF RVHICGICGLMTVIAKLNHNQFECKGCDNKIDIYQIHIPY AAKLLFQELMAMNITPRLYTDRSRDF Description Functional site 1) chain B residue 1163 type sequence C description BINDING SITE FOR RESIDUE ZN B 2225 source : AC4 2) chain B residue 1166 type sequence C description BINDING SITE FOR RESIDUE ZN B 2225 source : AC4 3) chain B residue 1182 type sequence C description BINDING SITE FOR RESIDUE ZN B 2225 source : AC4 4) chain B residue 1185 type sequence C description BINDING SITE FOR RESIDUE ZN B 2225 source : AC4 5) chain B residue 763 type sequence Q description BINDING SITE FOR CHAIN M OF ALPHA-AMANITIN source : BC1 6) chain B residue 837 type catalytic sequence D description 788 source MCSA : MCSA1 7) chain B residue 977-989 type prosite sequence GDKFASRHGQKGT description RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT source prosite : PS01166 8) chain B residue 1185 type MOD_RES sequence C description 4-hydroxyproline => ECO:0000269|PubMed:11805306, ECO:0000269|PubMed:363352, ECO:0000269|PubMed:4865716 source Swiss-Prot : SWS_FT_FI2

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