eF-site ID 2vum-A PDB Code 2vum Chain A click to enlarge Title Alpha-amanitin inhibited complete RNA polymerase II elongation complex Classification TRANSFERASE Compound DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 Source ORGANISM_COMMON: BAKERS' YEAST; ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE; Sequence A:  VGQQYSSAPLRTVKEVQFGLFSPEEVRAISVAKIRFPETM DETQTRAKIGGLNDPRLGSIDRNLKCQTCQEGMNECPGHF GHIDLAKPVFHVGFIAKIKKVCECVCMHCGKLLLDEHNEL MRQALAIKDSKKRFAAIWTLCKTKMVCETDVPSEDDPTQL VSRGGCGNTQPTIRKDGLKLVGSWKDEPELRVLSTEEILN IFKHISVKDFTSLGFNEVFSRPEWMILTCLPVPPPPVRPS ISFNESQRGEDDLTFKLADILKANISLETLEHNGAPHHAI EEAESLLQFHVATYMDNDIAGQPQALQKSGRPVKSIRARL KGKEGRIRGNLMGKRVDFSARTVISGDPNLELDQVGVPKS IAKTLTYPEVVTPYNIDRLTQLVRNGPNEHPGAKYVIRDS GDRIDLRYSKRAGDIQLQYGWKVERHIMDNDPVLFNRQPS LHKMSMMAHRVKVIPYSTFRLNLSVTSPYNADFDGDEMNL HVPQSEETRAELSQLCAVPLQIVSPQSNKPCMGIVQDTLC GIRKLTLRDTFIELDQVLNMLYWVPDWDGVIPTPAIIKPK PLWSGKQILSVAIPNGIHLQRFDEGTTLLSPKDNGMLIID GQIIFGVVEKKTVGSSNGGLIHVVTREKGPQVCAKLFGNI QKVVNFWLLHNGFSTGIGDTIADGPTMREITETIAEAKKK VLDVTKEAQANLLTAKHGMTLRESFEDNVVRFLNEARDKA GRLAEVNLKDLNNVKQMVMAGSKGSFINIAQMSACVGQQS VEGKRIAFGFVDRTLPHFSKDDYSPESKGFVENSYLRGLT PQEFFFHAMGGREGLIDTAVKTAETGYIQRRLVKALEDIM VHYDNTTRNSLGNVIQFIYGEDGMDAAHIEKQSLDTIGGS DAAFEKRYRVDLLNTDHTLDPSLLESGSEILGDLKLQVLL DEEYKQLVKDRKFLREVFVDGEANWPLPVNIRRIIQNAQQ TFHIDHTKPSDLTIKDIVLGVKDLQENLLVLRGKNEIIQN AQRDAVTLFCCLLRSRLATRRVLQEYRLTKQAFDWVLSNI EAQFLRSVVHPGEMVGVLAAQSIGEPATQMTLNTFHVTSG VPRLKEILNVAKNMKTPSLTVYLEPGHAADQEQAKLIRSA IEHTTLKSVTIASEIYYDPDPRSTVIPEDEEIIQLHFSLQ QSPWLLRLELDRAAMNDKDLTMGQVGERIKQTFKNDLFVI WSEDNDEKLIIRCRVVAEEDHMLKKIENTMLENITLRGVE NIERVVMMKYDRKVPSPTGEYVKEPEWVLETDGVNLSEVM TVPGIDPTRIYTNSFIDIMEVLGIEAGRAALYKEVYNVIA SDGSYVNYRHMALLVDVMTTQGGLTSVTRHGFNRSNTGAL MRCSFEETVEILFEAGASAELDDCRGVSENVILGQMAPIG TGAFDVMIDEESLVKYMP Description Functional site 1) chain A residue 107 type sequence C description BINDING SITE FOR RESIDUE ZN A 2456 source : AC1 2) chain A residue 108 type sequence M description BINDING SITE FOR RESIDUE ZN A 2456 source : AC1 3) chain A residue 110 type sequence C description BINDING SITE FOR RESIDUE ZN A 2456 source : AC1 4) chain A residue 148 type sequence C description BINDING SITE FOR RESIDUE ZN A 2456 source : AC1 5) chain A residue 166 type sequence G description BINDING SITE FOR RESIDUE ZN A 2456 source : AC1 6) chain A residue 167 type sequence C description BINDING SITE FOR RESIDUE ZN A 2456 source : AC1 7) chain A residue 67 type sequence C description BINDING SITE FOR RESIDUE ZN A 2457 source : AC2 8) chain A residue 70 type sequence C description BINDING SITE FOR RESIDUE ZN A 2457 source : AC2 9) chain A residue 77 type sequence C description BINDING SITE FOR RESIDUE ZN A 2457 source : AC2 10) chain A residue 80 type sequence H description BINDING SITE FOR RESIDUE ZN A 2457 source : AC2 11) chain A residue 481 type sequence D description BINDING SITE FOR RESIDUE MG A 2458 source : AC3 12) chain A residue 483 type sequence D description BINDING SITE FOR RESIDUE MG A 2458 source : AC3 13) chain A residue 485 type sequence D description BINDING SITE FOR RESIDUE MG A 2458 source : AC3 14) chain A residue 723 type sequence N description BINDING SITE FOR CHAIN M OF ALPHA-AMANITIN source : BC1 15) chain A residue 726 type sequence R description BINDING SITE FOR CHAIN M OF ALPHA-AMANITIN source : BC1 16) chain A residue 759 type sequence A description BINDING SITE FOR CHAIN M OF ALPHA-AMANITIN source : BC1 17) chain A residue 760 type sequence Q description BINDING SITE FOR CHAIN M OF ALPHA-AMANITIN source : BC1 18) chain A residue 764 type sequence C description BINDING SITE FOR CHAIN M OF ALPHA-AMANITIN source : BC1 19) chain A residue 765 type sequence V description BINDING SITE FOR CHAIN M OF ALPHA-AMANITIN source : BC1 20) chain A residue 766 type sequence G description BINDING SITE FOR CHAIN M OF ALPHA-AMANITIN source : BC1 21) chain A residue 767 type sequence Q description BINDING SITE FOR CHAIN M OF ALPHA-AMANITIN source : BC1 22) chain A residue 768 type sequence Q description BINDING SITE FOR CHAIN M OF ALPHA-AMANITIN source : BC1 23) chain A residue 769 type sequence S description BINDING SITE FOR CHAIN M OF ALPHA-AMANITIN source : BC1 24) chain A residue 772 type sequence G description BINDING SITE FOR CHAIN M OF ALPHA-AMANITIN source : BC1 25) chain A residue 819 type sequence G description BINDING SITE FOR CHAIN M OF ALPHA-AMANITIN source : BC1 26) chain A residue 820 type sequence G description BINDING SITE FOR CHAIN M OF ALPHA-AMANITIN source : BC1 27) chain A residue 822 type sequence E description BINDING SITE FOR CHAIN M OF ALPHA-AMANITIN source : BC1 28) chain A residue 1085 type sequence H description BINDING SITE FOR CHAIN M OF ALPHA-AMANITIN source : BC1 29) chain A residue 483 type MOD_RES sequence D description (3R,4S)-4-hydroxyisoleucine; in form gamma-amanitin => ECO:0000269|PubMed:11805306 source Swiss-Prot : SWS_FT_FI1 30) chain A residue 485 type MOD_RES sequence D description (3R,4S)-4-hydroxyisoleucine; in form gamma-amanitin => ECO:0000269|PubMed:11805306 source Swiss-Prot : SWS_FT_FI1 31) chain A residue 107 type MOD_RES sequence C description (3R,4S)-4-hydroxyisoleucine; in form gamma-amanitin => ECO:0000269|PubMed:11805306 source Swiss-Prot : SWS_FT_FI1 32) chain A residue 110 type MOD_RES sequence C description (3R,4S)-4-hydroxyisoleucine; in form gamma-amanitin => ECO:0000269|PubMed:11805306 source Swiss-Prot : SWS_FT_FI1 33) chain A residue 148 type MOD_RES sequence C description (3R,4S)-4-hydroxyisoleucine; in form gamma-amanitin => ECO:0000269|PubMed:11805306 source Swiss-Prot : SWS_FT_FI1 34) chain A residue 167 type MOD_RES sequence C description (3R,4S)-4-hydroxyisoleucine; in form gamma-amanitin => ECO:0000269|PubMed:11805306 source Swiss-Prot : SWS_FT_FI1 35) chain A residue 481 type MOD_RES sequence D description (3R,4S)-4-hydroxyisoleucine; in form gamma-amanitin => ECO:0000269|PubMed:11805306 source Swiss-Prot : SWS_FT_FI1 36) chain A residue 483 type catalytic sequence D description 788 source MCSA : MCSA1 37) chain A residue 485 type catalytic sequence D description 788 source MCSA : MCSA1 38) chain A residue 1085 type catalytic sequence H description 788 source MCSA : MCSA1

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