eF-site ID 2vt4-ABCD PDB Code 2vt4 Chain A, B, C, D click to enlarge Title TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND CYANOPINDOLOL Classification RECEPTOR Compound BETA1 ADRENERGIC RECEPTOR Source (ADRB1_MELGA) Sequence A:  WEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLF ITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTS LDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAK VIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCC DFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQIR EHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWL FVAFNWLGYANSAMNPIIYCRSPDFRKAFKRLLA B:  QWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNL FITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWT SLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARA KVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGC CDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQI REHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDW LFVAFNWLGYANSAMNPIIYCRSPDFRKAFKRLLAF C:  QWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNL FITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWT SLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARA KVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGC CDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQI REHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDW LFVAFNWLGYANSAMNPIIYCRS D:  EAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFI TSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSL DVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKV IICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCD FVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQIRE HKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLF VAFNWLGYANSAMNPIIYCRSPDFRKAFKRLL Description Functional site 1) chain A residue 68-76 type TOPO_DOM sequence STQRLQTLT description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 2) chain A residue 138-155 type TOPO_DOM sequence DRYLAITSPFRYQSLMTR description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 3) chain A residue 232-315 type TOPO_DOM sequence REAKEQIREHKALKTLGIIMGVFTLCWLPFFLVNIVNVF description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 4) chain B residue 68-76 type TOPO_DOM sequence STQRLQTLT description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 5) chain B residue 138-155 type TOPO_DOM sequence DRYLAITSPFRYQSLMTR description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 6) chain B residue 232-315 type TOPO_DOM sequence REAKEQIREHKALKTLGIIMGVFTLCWLPFFLVNIVNVF description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 7) chain C residue 68-76 type TOPO_DOM sequence STQRLQTLT description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 8) chain C residue 138-155 type TOPO_DOM sequence DRYLAITSPFRYQSLMTR description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 9) chain C residue 232-315 type TOPO_DOM sequence REAKEQIREHKALKTLGIIMGVFTLCWLPFFLVNIVNVF description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 10) chain D residue 68-76 type TOPO_DOM sequence STQRLQTLT description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 11) chain D residue 138-155 type TOPO_DOM sequence DRYLAITSPFRYQSLMTR description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 12) chain D residue 232-315 type TOPO_DOM sequence REAKEQIREHKALKTLGIIMGVFTLCWLPFFLVNIVNVF description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 13) chain B residue 316-320 type TOPO_DOM sequence NRDLV description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 14) chain A residue 104-115 type TOPO_DOM sequence RGTWLWGSFLCE description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 15) chain A residue 180-205 type TOPO_DOM sequence HWWRDEDPQALKCYQDPGCCDFVTNR description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 16) chain A residue 316-320 type TOPO_DOM sequence NRDLV description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 17) chain B residue 104-115 type TOPO_DOM sequence RGTWLWGSFLCE description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 18) chain B residue 180-205 type TOPO_DOM sequence HWWRDEDPQALKCYQDPGCCDFVTNR description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 19) chain C residue 104-115 type TOPO_DOM sequence RGTWLWGSFLCE description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 20) chain C residue 180-205 type TOPO_DOM sequence HWWRDEDPQALKCYQDPGCCDFVTNR description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 21) chain C residue 316-320 type TOPO_DOM sequence NRDLV description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 22) chain D residue 104-115 type TOPO_DOM sequence RGTWLWGSFLCE description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 23) chain D residue 180-205 type TOPO_DOM sequence HWWRDEDPQALKCYQDPGCCDFVTNR description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 24) chain D residue 316-320 type TOPO_DOM sequence NRDLV description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 25) chain B residue 329 type BINDING sequence N description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 26) chain A residue 121 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 27) chain A residue 211 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 28) chain A residue 329 type BINDING sequence N description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 29) chain B residue 121 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 30) chain B residue 211 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 31) chain C residue 121 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 32) chain C residue 211 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 33) chain C residue 329 type BINDING sequence N description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 34) chain D residue 121 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 35) chain D residue 211 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 36) chain D residue 329 type BINDING sequence N description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 37) chain A residue 358 type LIPID sequence A description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI11 38) chain B residue 358 type LIPID sequence A description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI11 39) chain A residue 127-143 type prosite sequence ASIETLCVIAIDRYLAI description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIeTLCVIAIDRYLaI source prosite : PS00237 40) chain B residue 39-67 type TRANSMEM sequence QWEAGMSLLMALVVLLIVAGNVLVIAAIG description Helical; Name=1 source Swiss-Prot : SWS_FT_FI1 41) chain C residue 39-67 type TRANSMEM sequence QWEAGMSLLMALVVLLIVAGNVLVIAAIG description Helical; Name=1 source Swiss-Prot : SWS_FT_FI1 42) chain A residue 77-103 type TRANSMEM sequence NLFITSLACADLVVGLLVVPFGATLVV description Helical; Name=2 source Swiss-Prot : SWS_FT_FI3 43) chain B residue 77-103 type TRANSMEM sequence NLFITSLACADLVVGLLVVPFGATLVV description Helical; Name=2 source Swiss-Prot : SWS_FT_FI3 44) chain C residue 77-103 type TRANSMEM sequence NLFITSLACADLVVGLLVVPFGATLVV description Helical; Name=2 source Swiss-Prot : SWS_FT_FI3 45) chain D residue 77-103 type TRANSMEM sequence NLFITSLACADLVVGLLVVPFGATLVV description Helical; Name=2 source Swiss-Prot : SWS_FT_FI3 46) chain A residue 116-137 type TRANSMEM sequence LWTSLDVLCVTASIETLCVIAI description Helical; Name=3 source Swiss-Prot : SWS_FT_FI5 47) chain B residue 116-137 type TRANSMEM sequence LWTSLDVLCVTASIETLCVIAI description Helical; Name=3 source Swiss-Prot : SWS_FT_FI5 48) chain C residue 116-137 type TRANSMEM sequence LWTSLDVLCVTASIETLCVIAI description Helical; Name=3 source Swiss-Prot : SWS_FT_FI5 49) chain D residue 116-137 type TRANSMEM sequence LWTSLDVLCVTASIETLCVIAI description Helical; Name=3 source Swiss-Prot : SWS_FT_FI5 50) chain A residue 156-179 type TRANSMEM sequence ARAKVIICTVWAISALVSFLPIMM description Helical; Name=4 source Swiss-Prot : SWS_FT_FI6 51) chain B residue 156-179 type TRANSMEM sequence ARAKVIICTVWAISALVSFLPIMM description Helical; Name=4 source Swiss-Prot : SWS_FT_FI6 52) chain C residue 156-179 type TRANSMEM sequence ARAKVIICTVWAISALVSFLPIMM description Helical; Name=4 source Swiss-Prot : SWS_FT_FI6 53) chain D residue 156-179 type TRANSMEM sequence ARAKVIICTVWAISALVSFLPIMM description Helical; Name=4 source Swiss-Prot : SWS_FT_FI6 54) chain A residue 206-231 type TRANSMEM sequence AYAIASSIISFYIPLLIMIFVALRVY description Helical; Name=5 source Swiss-Prot : SWS_FT_FI7 55) chain B residue 206-231 type TRANSMEM sequence AYAIASSIISFYIPLLIMIFVALRVY description Helical; Name=5 source Swiss-Prot : SWS_FT_FI7 56) chain C residue 206-231 type TRANSMEM sequence AYAIASSIISFYIPLLIMIFVALRVY description Helical; Name=5 source Swiss-Prot : SWS_FT_FI7 57) chain D residue 206-231 type TRANSMEM sequence AYAIASSIISFYIPLLIMIFVALRVY description Helical; Name=5 source Swiss-Prot : SWS_FT_FI7 58) chain B residue 286-315 type TRANSMEM sequence HKALKTLGIIMGVFTLCWLPFFLVNIVNVF description Helical; Name=6 source Swiss-Prot : SWS_FT_FI8 59) chain A residue 286-315 type TRANSMEM sequence HKALKTLGIIMGVFTLCWLPFFLVNIVNVF description Helical; Name=6 source Swiss-Prot : SWS_FT_FI8 60) chain C residue 286-315 type TRANSMEM sequence HKALKTLGIIMGVFTLCWLPFFLVNIVNVF description Helical; Name=6 source Swiss-Prot : SWS_FT_FI8 61) chain D residue 286-315 type TRANSMEM sequence HKALKTLGIIMGVFTLCWLPFFLVNIVNVF description Helical; Name=6 source Swiss-Prot : SWS_FT_FI8 62) chain B residue 321-343 type TRANSMEM sequence PDWLFVAFNWLGYANSAMNPIIY description Helical; Name=7 source Swiss-Prot : SWS_FT_FI9 63) chain A residue 321-343 type TRANSMEM sequence PDWLFVAFNWLGYANSAMNPIIY description Helical; Name=7 source Swiss-Prot : SWS_FT_FI9 64) chain C residue 321-343 type TRANSMEM sequence PDWLFVAFNWLGYANSAMNPIIY description Helical; Name=7 source Swiss-Prot : SWS_FT_FI9 65) chain D residue 321-343 type TRANSMEM sequence PDWLFVAFNWLGYANSAMNPIIY description Helical; Name=7 source Swiss-Prot : SWS_FT_FI9

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