eF-site ID 2vst-AB
PDB Code 2vst
Chain A, B

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Title hPPARgamma Ligand binding domain in complex with 13-(S)-HODE
Classification RECEPTOR
Compound PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA
Source Homo sapiens (Human) (PPARG_HUMAN)
Sequence A:  LNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTD
KSPFVIYDMNSLMMGEDKIKEVAIRIFQGCQFRSVEAVQE
ITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMN
KDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFN
ALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQ
ALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQV
IKKTETDMSLHPLLQEIYKD
B:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKSPFVIY
DMNSLMMGEDKHITKEVAIRIFQGCQFRSVEAVQEITEYA
KSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVL
ISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELD
DSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQ
LKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTH
PLLQEIYK
Description


Functional site

1) chain A
residue 281
type
sequence I
description BINDING SITE FOR RESIDUE 243 A 1477
source : AC1

2) chain A
residue 285
type
sequence C
description BINDING SITE FOR RESIDUE 243 A 1477
source : AC1

3) chain A
residue 288
type
sequence R
description BINDING SITE FOR RESIDUE 243 A 1477
source : AC1

4) chain A
residue 326
type
sequence I
description BINDING SITE FOR RESIDUE 243 A 1477
source : AC1

5) chain A
residue 330
type
sequence L
description BINDING SITE FOR RESIDUE 243 A 1477
source : AC1

6) chain A
residue 339
type
sequence V
description BINDING SITE FOR RESIDUE 243 A 1477
source : AC1

7) chain A
residue 340
type
sequence L
description BINDING SITE FOR RESIDUE 243 A 1477
source : AC1

8) chain A
residue 341
type
sequence I
description BINDING SITE FOR RESIDUE 243 A 1477
source : AC1

9) chain A
residue 342
type
sequence S
description BINDING SITE FOR RESIDUE 243 A 1477
source : AC1

10) chain A
residue 364
type
sequence M
description BINDING SITE FOR RESIDUE 243 A 1477
source : AC1

11) chain B
residue 266
type
sequence H
description BINDING SITE FOR RESIDUE 243 B 1476
source : AC2

12) chain B
residue 281
type
sequence I
description BINDING SITE FOR RESIDUE 243 B 1476
source : AC2

13) chain B
residue 288
type
sequence R
description BINDING SITE FOR RESIDUE 243 B 1476
source : AC2

14) chain B
residue 341
type
sequence I
description BINDING SITE FOR RESIDUE 243 B 1476
source : AC2

15) chain B
residue 342
type
sequence S
description BINDING SITE FOR RESIDUE 243 B 1476
source : AC2

16) chain B
residue 364
type
sequence M
description BINDING SITE FOR RESIDUE 243 B 1476
source : AC2

17) chain B
residue 316
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
source Swiss-Prot : SWS_FT_FI1

18) chain B
residue 353
type BINDING
sequence L
description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
source Swiss-Prot : SWS_FT_FI1

19) chain A
residue 316
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
source Swiss-Prot : SWS_FT_FI1

20) chain A
residue 353
type BINDING
sequence L
description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
source Swiss-Prot : SWS_FT_FI1

21) chain A
residue 254
type CROSSLNK
sequence S
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649
source Swiss-Prot : SWS_FT_FI2

22) chain B
residue 254
type CROSSLNK
sequence S
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649
source Swiss-Prot : SWS_FT_FI2


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