eF-site ID 2vsr-AB PDB Code 2vsr Chain A, B click to enlarge Title hPPARgamma Ligand binding domain in complex with 9-(S)-HODE Classification RECEPTOR Compound PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA Source Homo sapiens (Human) (PPARG_HUMAN) Sequence A:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSP FVIYDMNSLMMGEDKIKEVAIRIFQGCQFRSVEAVQEITE YAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDG VLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALE LDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALE LQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKK TETDMSLHPLLQEIYKD B:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKDKSPFV IYDMNSLMMGEDKIKFKHITPKEVAIRIFQGCQFRSVEAV QEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASL MNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVK FNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNL LQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLL QVIKKTHPLLQEIYK Description Functional site 1) chain A residue 281 type sequence I description BINDING SITE FOR RESIDUE 9HO A 1477 source : AC1 2) chain A residue 285 type sequence C description BINDING SITE FOR RESIDUE 9HO A 1477 source : AC1 3) chain A residue 288 type sequence R description BINDING SITE FOR RESIDUE 9HO A 1477 source : AC1 4) chain A residue 289 type sequence S description BINDING SITE FOR RESIDUE 9HO A 1477 source : AC1 5) chain A residue 323 type sequence H description BINDING SITE FOR RESIDUE 9HO A 1477 source : AC1 6) chain A residue 330 type sequence L description BINDING SITE FOR RESIDUE 9HO A 1477 source : AC1 7) chain A residue 353 type sequence L description BINDING SITE FOR RESIDUE 9HO A 1477 source : AC1 8) chain A residue 363 type sequence F description BINDING SITE FOR RESIDUE 9HO A 1477 source : AC1 9) chain A residue 364 type sequence M description BINDING SITE FOR RESIDUE 9HO A 1477 source : AC1 10) chain A residue 449 type sequence H description BINDING SITE FOR RESIDUE 9HO A 1477 source : AC1 11) chain A residue 473 type sequence Y description BINDING SITE FOR RESIDUE 9HO A 1477 source : AC1 12) chain A residue 226 type sequence F description BINDING SITE FOR RESIDUE 9HO A 1478 source : AC2 13) chain A residue 227 type sequence P description BINDING SITE FOR RESIDUE 9HO A 1478 source : AC2 14) chain A residue 228 type sequence L description BINDING SITE FOR RESIDUE 9HO A 1478 source : AC2 15) chain A residue 288 type sequence R description BINDING SITE FOR RESIDUE 9HO A 1478 source : AC2 16) chain A residue 295 type sequence E description BINDING SITE FOR RESIDUE 9HO A 1478 source : AC2 17) chain A residue 326 type sequence I description BINDING SITE FOR RESIDUE 9HO A 1478 source : AC2 18) chain A residue 329 type sequence M description BINDING SITE FOR RESIDUE 9HO A 1478 source : AC2 19) chain A residue 330 type sequence L description BINDING SITE FOR RESIDUE 9HO A 1478 source : AC2 20) chain A residue 333 type sequence L description BINDING SITE FOR RESIDUE 9HO A 1478 source : AC2 21) chain A residue 342 type sequence S description BINDING SITE FOR RESIDUE 9HO A 1478 source : AC2 22) chain A residue 343 type sequence E description BINDING SITE FOR RESIDUE 9HO A 1478 source : AC2 23) chain B residue 282 type sequence F description BINDING SITE FOR RESIDUE 9HO B 1476 source : AC3 24) chain B residue 285 type sequence C description BINDING SITE FOR RESIDUE 9HO B 1476 source : AC3 25) chain B residue 286 type sequence Q description BINDING SITE FOR RESIDUE 9HO B 1476 source : AC3 26) chain B residue 288 type sequence R description BINDING SITE FOR RESIDUE 9HO B 1476 source : AC3 27) chain B residue 289 type sequence S description BINDING SITE FOR RESIDUE 9HO B 1476 source : AC3 28) chain B residue 326 type sequence I description BINDING SITE FOR RESIDUE 9HO B 1476 source : AC3 29) chain B residue 327 type sequence Y description BINDING SITE FOR RESIDUE 9HO B 1476 source : AC3 30) chain B residue 333 type sequence L description BINDING SITE FOR RESIDUE 9HO B 1476 source : AC3 31) chain B residue 360 type sequence F description BINDING SITE FOR RESIDUE 9HO B 1476 source : AC3 32) chain B residue 363 type sequence F description BINDING SITE FOR RESIDUE 9HO B 1476 source : AC3 33) chain B residue 364 type sequence M description BINDING SITE FOR RESIDUE 9HO B 1476 source : AC3 34) chain A residue 316 type BINDING sequence T description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 35) chain A residue 353 type BINDING sequence L description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 36) chain B residue 316 type BINDING sequence T description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 37) chain B residue 353 type BINDING sequence L description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 38) chain A residue 254 type CROSSLNK sequence S description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2 39) chain B residue 254 type CROSSLNK sequence S description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

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