eF-site ID 2vrt-ABCDEFGH PDB Code 2vrt Chain A, B, C, D, E, F, G, H click to enlarge Title Crystal Structure of E. coli RNase E possessing M1 RNA fragments - Catalytic Domain Classification HYDROLASE Compound RIBONUCLEASE E Source Escherichia coli (strain K12) (2VRT) Sequence A:  MKRMLINATQQEELRVALVDGQRLYDLDIESPEQKKANIY KGKITRIEPSLEAAFVDYGAERHGFLPLKEIAREYFPRPN IKDVLREGQEVIVQIDKEERGNKGAALTTFISLAGSYLVL MPNNPRAGGISRRIEGDDRTELKEALASLELPEGMGLIVR TAGVGKSAEALQWDLSFRLKHWEAIKKAAESRPAPFLIHQ ESNVIVRAFRDYLRQDIGEILIDNPKVLELARQHIAALGR PDFSSKIKLYTGEIPLFSHYQIESQIESAFQREVRLPSGG SIVIDSTEALTAIDINSARDIEETAFNTNLEAADEIARQL RLRDLGGLIVIDFIDMTPVRHQRAVENRLREAVRQDRARI QISHISRFGLLEMSRQRLSHVCCTVRDNESLSLSILRLIE EEALKENTAIVPVPIASYLLNEKRSAVNAIETRQDGVRCV IVPNDQMETPHYHVLRVTPTLSYMLPKL B:  MKRMLINATQQEELRVALVDGQRLYDLDIFISLAGSYLVL MPNNPRAGGISRRIEGDDRTELKEALASLELPEGMGLIVR TAGVSAEALQWDLSFRLKHWEAIKKAAESAPFLIHQNVIV RAFRDYLRDIGEILIDNPKVLELARQHIAPDFSSKIKLYT GEIPLFSHYQIESQIESAFQREVRLPSGGSIVIDSTEALT AIDINSAGDIEETAFNTNLEAADEIARQLRLRDLGGLIVI DFIDMTPVRHQRAVENRLREAVRQDRARIQISHISRFGLL EMSRQRLSPSHHVCPRCSGTGTVRDNESLSLSILRLIEEE ALKENTQEVHAIVPVPIASYLLNEKRSAVNAIETRQDGVR CVIVPNDQMETPHYHVLRVRKGEETPTLSYMLPKLHEE C:  MKRMLINATQQEELRVALVDGQRLYDLDIESPFISLAGSY LVLMPNNPRAGGISRRIEGDELKEALASLELPEGMGLIVR TAGVGKSAEALQWDLSFRLKHWEAIKKAAESRPAPFLIHQ NVIVRAFRDYLRQDIGEILIDNPKVLELARQHIAALGRPD FSSKIKLYTGEIPLFSHYQIESQIESAFQREVRLPSGGSI VIDSTEALTAIDINSAGDIEETAFNTNLEAADEIARQLRL RDLGGLIVIDFIDMTPVRHQRAVENRLREAVRQDRARIQI SHISRFGLLEMSRQRLSLGESSHHVCPRCSGTGTVRDNES LSLSILRLIEEEALKENTQEVHAIVPVPIASYLLNEKRSA VNAIETRQDGVRCVIVPNDQMETPHYHVLRVRKGEETPTL SYMLPKLHEEA D:  MKRMLINATQQEELRVALVDGQRLYDLDIESPEQKKANIY KGKITRIEPSLEAAFVDYGAERHGFLPLKEIAREYFPRPN IKDVLREGQEVIVQIDKEERGNKGAALTTFISLAGSYLVL MPNNPRAGGISRRIEDDRTELKEALASLELPEGMGLIVRT AGVGKSAEALQWDLSFRLKHWEAIKKAAESRPAPFLIHQE SNVIVRAFRDYLRQDIGEILIDNPKVLELARQHIAALGRP DFSSKIKLYTGEIPLFSHYQIESQIESAFQREVRLPSGGS IVIDSTEALTAIDINSARDIEETAFNTNLEAADEIARQLR LRDLGGLIVIDFIDMTPVRHQRAVENRLREAVRQDRARIQ ISHISRFGLLEMSRQRLSSHHVCPRCSGTGTVRDNESLSL SILRLIEEEALKENTQEVHAIVPVPIASYLLNEKRSAVNA IETRQDGVRCVIVPNDQMETPHYHVLRVRKGEETPTLSYM LPKLHEE E:  UU F:  UU G:  UUG H:  UUG Description Functional site 1) chain A residue 404 type sequence C description BINDING SITE FOR RESIDUE ZN A1506 source : AC1 2) chain A residue 407 type sequence C description BINDING SITE FOR RESIDUE ZN A1506 source : AC1 3) chain B residue 404 type sequence C description BINDING SITE FOR RESIDUE ZN A1506 source : AC1 4) chain B residue 407 type sequence C description BINDING SITE FOR RESIDUE ZN A1506 source : AC1 5) chain C residue 404 type sequence C description BINDING SITE FOR RESIDUE ZN D1509 source : AC2 6) chain C residue 407 type sequence C description BINDING SITE FOR RESIDUE ZN D1509 source : AC2 7) chain D residue 404 type sequence C description BINDING SITE FOR RESIDUE ZN D1509 source : AC2 8) chain D residue 407 type sequence C description BINDING SITE FOR RESIDUE ZN D1509 source : AC2 9) chain A residue 303 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16237448 source Swiss-Prot : SWS_FT_FI1 10) chain A residue 346 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16237448 source Swiss-Prot : SWS_FT_FI1 11) chain B residue 303 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16237448 source Swiss-Prot : SWS_FT_FI1 12) chain B residue 346 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16237448 source Swiss-Prot : SWS_FT_FI1 13) chain C residue 303 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16237448 source Swiss-Prot : SWS_FT_FI1 14) chain C residue 346 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16237448 source Swiss-Prot : SWS_FT_FI1 15) chain D residue 303 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16237448 source Swiss-Prot : SWS_FT_FI1 16) chain D residue 346 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16237448 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 404 type BINDING sequence C description BINDING => ECO:0000269|PubMed:15779893, ECO:0000269|PubMed:18682225 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 407 type BINDING sequence C description BINDING => ECO:0000269|PubMed:15779893, ECO:0000269|PubMed:18682225 source Swiss-Prot : SWS_FT_FI2 19) chain B residue 404 type BINDING sequence C description BINDING => ECO:0000269|PubMed:15779893, ECO:0000269|PubMed:18682225 source Swiss-Prot : SWS_FT_FI2 20) chain B residue 407 type BINDING sequence C description BINDING => ECO:0000269|PubMed:15779893, ECO:0000269|PubMed:18682225 source Swiss-Prot : SWS_FT_FI2 21) chain C residue 404 type BINDING sequence C description BINDING => ECO:0000269|PubMed:15779893, ECO:0000269|PubMed:18682225 source Swiss-Prot : SWS_FT_FI2 22) chain C residue 407 type BINDING sequence C description BINDING => ECO:0000269|PubMed:15779893, ECO:0000269|PubMed:18682225 source Swiss-Prot : SWS_FT_FI2 23) chain D residue 404 type BINDING sequence C description BINDING => ECO:0000269|PubMed:15779893, ECO:0000269|PubMed:18682225 source Swiss-Prot : SWS_FT_FI2 24) chain D residue 407 type BINDING sequence C description BINDING => ECO:0000269|PubMed:15779893, ECO:0000269|PubMed:18682225 source Swiss-Prot : SWS_FT_FI2

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