eF-site ID 2vqw-G PDB Code 2vqw Chain G click to enlarge Title Structure of inhibitor-free HDAC4 catalytic domain (with gain-of- function mutation His332Tyr) Classification HYDROLASE Compound HISTONE DEACETYLASE 4 Source Homo sapiens (Human) (HDAC4_HUMAN) Sequence G:  RFTTGLVYDTLMLKHQCTCSSHPEHAGRIQSIWSRLQETG LRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLSVFVR LPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATG ELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQR LSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDG NFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYL AAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNL SARCFGYLTKQLMGLAGGRIVLALEGGYDLTAICDASEAC VSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYW RCLQRTTSTAGRSLIEAQTCEN Description Functional site 1) chain G residue 194 type sequence D description BINDING SITE FOR RESIDUE K G1407 source : AC1 2) chain G residue 196 type sequence D description BINDING SITE FOR RESIDUE K G1407 source : AC1 3) chain G residue 198 type sequence H description BINDING SITE FOR RESIDUE K G1407 source : AC1 4) chain G residue 217 type sequence S description BINDING SITE FOR RESIDUE K G1407 source : AC1 5) chain G residue 218 type sequence L description BINDING SITE FOR RESIDUE K G1407 source : AC1 6) chain G residue 207 type sequence F description BINDING SITE FOR RESIDUE K G1408 source : AC2 7) chain G residue 210 type sequence D description BINDING SITE FOR RESIDUE K G1408 source : AC2 8) chain G residue 213 type sequence V description BINDING SITE FOR RESIDUE K G1408 source : AC2 9) chain G residue 244 type sequence F description BINDING SITE FOR RESIDUE K G1408 source : AC2 10) chain G residue 196 type sequence D description BINDING SITE FOR RESIDUE ZN G1409 source : AC3 11) chain G residue 198 type sequence H description BINDING SITE FOR RESIDUE ZN G1409 source : AC3 12) chain G residue 290 type sequence D description BINDING SITE FOR RESIDUE ZN G1409 source : AC3 13) chain G residue 23 type sequence C description BINDING SITE FOR RESIDUE ZN G1410 source : AC4 14) chain G residue 25 type sequence C description BINDING SITE FOR RESIDUE ZN G1410 source : AC4 15) chain G residue 31 type sequence H description BINDING SITE FOR RESIDUE ZN G1410 source : AC4 16) chain G residue 107 type sequence C description BINDING SITE FOR RESIDUE ZN G1410 source : AC4 17) chain G residue 159 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 18) chain G residue 23 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 19) chain G residue 25 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 20) chain G residue 31 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 21) chain G residue 107 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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