eF-site ID 2vqv-AB PDB Code 2vqv Chain A, B click to enlarge Title Structure of HDAC4 catalytic domain with a gain-of-function mutation bound to a hydroxamic acid inhibitor Classification HYDROLASE Compound HISTONE DEACETYLASE 4 Source Homo sapiens (Human) (HDAC4_HUMAN) Sequence A:  RFTTGLVYDTLMLKHAGRIQSIWSRLQETGLRGKCEAIRG RKATLEELQTVHSEAHTLLYGTNPDTIWNEVHSAGAARLA VGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCY FNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSD PSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAF TGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFD AVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEG GYDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAV RSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCE B:  RFTTGLVYDTLMLKHAGRIQSIWSRLQETGLRGKCEAIRG RKATLEELQTVHSEAHTLLYGTNPLDTIWNEVHSAGAARL AVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFC YFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYS DPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMA FTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGF DAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALE GGYDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANA VRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCE Description Functional site 1) chain A residue 367 type sequence A description BINDING SITE FOR RESIDUE SO4 A 1406 source : AC1 2) chain B residue 72 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1406 source : AC2 3) chain B residue 73 type sequence E description BINDING SITE FOR RESIDUE SO4 B 1406 source : AC2 4) chain B residue 256 type sequence P description BINDING SITE FOR RESIDUE SO4 B 1407 source : AC3 5) chain B residue 366 type sequence N description BINDING SITE FOR RESIDUE SO4 B 1407 source : AC3 6) chain B residue 367 type sequence A description BINDING SITE FOR RESIDUE SO4 B 1407 source : AC3 7) chain B residue 20 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1408 source : AC4 8) chain B residue 37 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1408 source : AC4 9) chain B residue 154 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1408 source : AC4 10) chain A residue 194 type sequence D description BINDING SITE FOR RESIDUE K A 1407 source : AC5 11) chain A residue 196 type sequence D description BINDING SITE FOR RESIDUE K A 1407 source : AC5 12) chain A residue 198 type sequence H description BINDING SITE FOR RESIDUE K A 1407 source : AC5 13) chain A residue 217 type sequence S description BINDING SITE FOR RESIDUE K A 1407 source : AC5 14) chain A residue 218 type sequence L description BINDING SITE FOR RESIDUE K A 1407 source : AC5 15) chain A residue 207 type sequence F description BINDING SITE FOR RESIDUE K A 1408 source : AC6 16) chain A residue 210 type sequence D description BINDING SITE FOR RESIDUE K A 1408 source : AC6 17) chain A residue 213 type sequence V description BINDING SITE FOR RESIDUE K A 1408 source : AC6 18) chain A residue 244 type sequence F description BINDING SITE FOR RESIDUE K A 1408 source : AC6 19) chain B residue 194 type sequence D description BINDING SITE FOR RESIDUE K B 1409 source : AC7 20) chain B residue 196 type sequence D description BINDING SITE FOR RESIDUE K B 1409 source : AC7 21) chain B residue 198 type sequence H description BINDING SITE FOR RESIDUE K B 1409 source : AC7 22) chain B residue 217 type sequence S description BINDING SITE FOR RESIDUE K B 1409 source : AC7 23) chain B residue 218 type sequence L description BINDING SITE FOR RESIDUE K B 1409 source : AC7 24) chain B residue 207 type sequence F description BINDING SITE FOR RESIDUE K B 1410 source : AC8 25) chain B residue 210 type sequence D description BINDING SITE FOR RESIDUE K B 1410 source : AC8 26) chain B residue 213 type sequence V description BINDING SITE FOR RESIDUE K B 1410 source : AC8 27) chain B residue 244 type sequence F description BINDING SITE FOR RESIDUE K B 1410 source : AC8 28) chain A residue 156 type sequence P description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 29) chain A residue 159 type sequence H description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 30) chain A residue 167 type sequence G description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 31) chain A residue 168 type sequence F description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 32) chain A residue 198 type sequence H description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 33) chain A residue 227 type sequence F description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 34) chain A residue 290 type sequence D description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 35) chain A residue 330 type sequence G description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 36) chain A residue 332 type sequence Y description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 37) chain B residue 78 type sequence L description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 38) chain B residue 79 type sequence Y description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 39) chain B residue 81 type sequence T description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 40) chain B residue 124 type sequence A description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 41) chain A residue 78 type sequence L description BINDING SITE FOR RESIDUE HA3 B 1411 source : BC1 42) chain A residue 79 type sequence Y description BINDING SITE FOR RESIDUE HA3 B 1411 source : BC1 43) chain A residue 81 type sequence T description BINDING SITE FOR RESIDUE HA3 B 1411 source : BC1 44) chain A residue 124 type sequence A description BINDING SITE FOR RESIDUE HA3 B 1411 source : BC1 45) chain B residue 156 type sequence P description BINDING SITE FOR RESIDUE HA3 B 1411 source : BC1 46) chain B residue 159 type sequence H description BINDING SITE FOR RESIDUE HA3 B 1411 source : BC1 47) chain B residue 167 type sequence G description BINDING SITE FOR RESIDUE HA3 B 1411 source : BC1 48) chain B residue 168 type sequence F description BINDING SITE FOR RESIDUE HA3 B 1411 source : BC1 49) chain B residue 198 type sequence H description BINDING SITE FOR RESIDUE HA3 B 1411 source : BC1 50) chain B residue 227 type sequence F description BINDING SITE FOR RESIDUE HA3 B 1411 source : BC1 51) chain B residue 290 type sequence D description BINDING SITE FOR RESIDUE HA3 B 1411 source : BC1 52) chain B residue 332 type sequence Y description BINDING SITE FOR RESIDUE HA3 B 1411 source : BC1 53) chain A residue 196 type sequence D description BINDING SITE FOR RESIDUE ZN A 1410 source : BC2 54) chain A residue 198 type sequence H description BINDING SITE FOR RESIDUE ZN A 1410 source : BC2 55) chain A residue 290 type sequence D description BINDING SITE FOR RESIDUE ZN A 1410 source : BC2 56) chain B residue 196 type sequence D description BINDING SITE FOR RESIDUE ZN B 1412 source : BC3 57) chain B residue 198 type sequence H description BINDING SITE FOR RESIDUE ZN B 1412 source : BC3 58) chain B residue 290 type sequence D description BINDING SITE FOR RESIDUE ZN B 1412 source : BC3 59) chain A residue 159 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 60) chain B residue 159 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1

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