eF-site ID 2vqv-A PDB Code 2vqv Chain A click to enlarge Title Structure of HDAC4 catalytic domain with a gain-of-function mutation bound to a hydroxamic acid inhibitor Classification HYDROLASE Compound HISTONE DEACETYLASE 4 Source Homo sapiens (Human) (HDAC4_HUMAN) Sequence A:  RFTTGLVYDTLMLKHAGRIQSIWSRLQETGLRGKCEAIRG RKATLEELQTVHSEAHTLLYGTNPDTIWNEVHSAGAARLA VGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCY FNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSD PSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAF TGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFD AVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEG GYDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAV RSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCE Description Functional site 1) chain A residue 367 type sequence A description BINDING SITE FOR RESIDUE SO4 A 1406 source : AC1 2) chain A residue 194 type sequence D description BINDING SITE FOR RESIDUE K A 1407 source : AC5 3) chain A residue 196 type sequence D description BINDING SITE FOR RESIDUE K A 1407 source : AC5 4) chain A residue 198 type sequence H description BINDING SITE FOR RESIDUE K A 1407 source : AC5 5) chain A residue 217 type sequence S description BINDING SITE FOR RESIDUE K A 1407 source : AC5 6) chain A residue 218 type sequence L description BINDING SITE FOR RESIDUE K A 1407 source : AC5 7) chain A residue 207 type sequence F description BINDING SITE FOR RESIDUE K A 1408 source : AC6 8) chain A residue 210 type sequence D description BINDING SITE FOR RESIDUE K A 1408 source : AC6 9) chain A residue 213 type sequence V description BINDING SITE FOR RESIDUE K A 1408 source : AC6 10) chain A residue 244 type sequence F description BINDING SITE FOR RESIDUE K A 1408 source : AC6 11) chain A residue 156 type sequence P description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 12) chain A residue 159 type sequence H description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 13) chain A residue 167 type sequence G description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 14) chain A residue 168 type sequence F description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 15) chain A residue 198 type sequence H description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 16) chain A residue 227 type sequence F description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 17) chain A residue 290 type sequence D description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 18) chain A residue 330 type sequence G description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 19) chain A residue 332 type sequence Y description BINDING SITE FOR RESIDUE HA3 A 1409 source : AC9 20) chain A residue 78 type sequence L description BINDING SITE FOR RESIDUE HA3 B 1411 source : BC1 21) chain A residue 79 type sequence Y description BINDING SITE FOR RESIDUE HA3 B 1411 source : BC1 22) chain A residue 81 type sequence T description BINDING SITE FOR RESIDUE HA3 B 1411 source : BC1 23) chain A residue 124 type sequence A description BINDING SITE FOR RESIDUE HA3 B 1411 source : BC1 24) chain A residue 196 type sequence D description BINDING SITE FOR RESIDUE ZN A 1410 source : BC2 25) chain A residue 198 type sequence H description BINDING SITE FOR RESIDUE ZN A 1410 source : BC2 26) chain A residue 290 type sequence D description BINDING SITE FOR RESIDUE ZN A 1410 source : BC2 27) chain A residue 159 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1

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