eF-site ID 2vqo-B PDB Code 2vqo Chain B click to enlarge Title Structure of HDAC4 catalytic domain with a gain-of-function muation bound to a trifluoromethylketone inhbitor Classification HYDROLASE Compound HISTONE DEACETYLASE 4 Source Homo sapiens (Human) (HDAC4_HUMAN) Sequence B:  RFTTGLVYDTLMLKHAGRIQSIWSRLQETGLRGKCEAIRG RKATLEELQTVHSEAHTLLYGTNPLDSDTIWNEVHSAGAA RLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMG FCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAF YSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVN MAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSS GFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLA LEGGYDLTAICDASEACVSALLGNELDPLPEKVLQQRPNA NAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCE Description Functional site 1) chain B residue 78 type sequence L description BINDING SITE FOR RESIDUE TFG A1410 source : AC5 2) chain B residue 79 type sequence Y description BINDING SITE FOR RESIDUE TFG A1410 source : AC5 3) chain B residue 81 type sequence T description BINDING SITE FOR RESIDUE TFG A1410 source : AC5 4) chain B residue 124 type sequence A description BINDING SITE FOR RESIDUE TFG A1410 source : AC5 5) chain B residue 20 type sequence K description BINDING SITE FOR RESIDUE SO4 B1406 source : AC7 6) chain B residue 37 type sequence R description BINDING SITE FOR RESIDUE SO4 B1406 source : AC7 7) chain B residue 38 type sequence I description BINDING SITE FOR RESIDUE SO4 B1406 source : AC7 8) chain B residue 154 type sequence R description BINDING SITE FOR RESIDUE SO4 B1406 source : AC7 9) chain B residue 194 type sequence D description BINDING SITE FOR RESIDUE K B1407 source : AC8 10) chain B residue 196 type sequence D description BINDING SITE FOR RESIDUE K B1407 source : AC8 11) chain B residue 198 type sequence H description BINDING SITE FOR RESIDUE K B1407 source : AC8 12) chain B residue 217 type sequence S description BINDING SITE FOR RESIDUE K B1407 source : AC8 13) chain B residue 218 type sequence L description BINDING SITE FOR RESIDUE K B1407 source : AC8 14) chain B residue 207 type sequence F description BINDING SITE FOR RESIDUE K B1408 source : AC9 15) chain B residue 210 type sequence D description BINDING SITE FOR RESIDUE K B1408 source : AC9 16) chain B residue 213 type sequence V description BINDING SITE FOR RESIDUE K B1408 source : AC9 17) chain B residue 244 type sequence F description BINDING SITE FOR RESIDUE K B1408 source : AC9 18) chain B residue 156 type sequence P description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 19) chain B residue 158 type sequence H description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 20) chain B residue 159 type sequence H description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 21) chain B residue 167 type sequence G description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 22) chain B residue 168 type sequence F description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 23) chain B residue 196 type sequence D description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 24) chain B residue 198 type sequence H description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 25) chain B residue 227 type sequence F description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 26) chain B residue 290 type sequence D description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 27) chain B residue 299 type sequence L description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 28) chain B residue 330 type sequence G description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 29) chain B residue 196 type sequence D description BINDING SITE FOR RESIDUE ZN B1410 source : BC2 30) chain B residue 198 type sequence H description BINDING SITE FOR RESIDUE ZN B1410 source : BC2 31) chain B residue 290 type sequence D description BINDING SITE FOR RESIDUE ZN B1410 source : BC2 32) chain B residue 159 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1

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