eF-site ID 2vqo-AB PDB Code 2vqo Chain A, B click to enlarge Title Structure of HDAC4 catalytic domain with a gain-of-function muation bound to a trifluoromethylketone inhbitor Classification HYDROLASE Compound HISTONE DEACETYLASE 4 Source Homo sapiens (Human) (HDAC4_HUMAN) Sequence A:  RFTTGLVYDTLMLKHQAGRIQSIWSRLQETGLRGKCEAIR GRKATLEELQTVHSEAHTLLYGTNPLVDSDTIWNEVHSAG AARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTP MGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQ AFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFN VNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLV SSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIV LALEGGYDLTAICDASEACVSALLGNELDPLPEKVLQQRP NANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCE B:  RFTTGLVYDTLMLKHAGRIQSIWSRLQETGLRGKCEAIRG RKATLEELQTVHSEAHTLLYGTNPLDSDTIWNEVHSAGAA RLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMG FCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAF YSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVN MAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSS GFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLA LEGGYDLTAICDASEACVSALLGNELDPLPEKVLQQRPNA NAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCE Description Functional site 1) chain A residue 20 type sequence K description BINDING SITE FOR RESIDUE SO4 A1406 source : AC1 2) chain A residue 37 type sequence R description BINDING SITE FOR RESIDUE SO4 A1406 source : AC1 3) chain A residue 38 type sequence I description BINDING SITE FOR RESIDUE SO4 A1406 source : AC1 4) chain A residue 154 type sequence R description BINDING SITE FOR RESIDUE SO4 A1406 source : AC1 5) chain A residue 42 type sequence W description BINDING SITE FOR RESIDUE SO4 A1407 source : AC2 6) chain A residue 46 type sequence Q description BINDING SITE FOR RESIDUE SO4 A1407 source : AC2 7) chain A residue 51 type sequence R description BINDING SITE FOR RESIDUE SO4 A1407 source : AC2 8) chain A residue 194 type sequence D description BINDING SITE FOR RESIDUE K A1408 source : AC3 9) chain A residue 196 type sequence D description BINDING SITE FOR RESIDUE K A1408 source : AC3 10) chain A residue 198 type sequence H description BINDING SITE FOR RESIDUE K A1408 source : AC3 11) chain A residue 217 type sequence S description BINDING SITE FOR RESIDUE K A1408 source : AC3 12) chain A residue 218 type sequence L description BINDING SITE FOR RESIDUE K A1408 source : AC3 13) chain A residue 207 type sequence F description BINDING SITE FOR RESIDUE K A1409 source : AC4 14) chain A residue 210 type sequence D description BINDING SITE FOR RESIDUE K A1409 source : AC4 15) chain A residue 213 type sequence V description BINDING SITE FOR RESIDUE K A1409 source : AC4 16) chain A residue 244 type sequence F description BINDING SITE FOR RESIDUE K A1409 source : AC4 17) chain A residue 156 type sequence P description BINDING SITE FOR RESIDUE TFG A1410 source : AC5 18) chain A residue 158 type sequence H description BINDING SITE FOR RESIDUE TFG A1410 source : AC5 19) chain A residue 159 type sequence H description BINDING SITE FOR RESIDUE TFG A1410 source : AC5 20) chain A residue 167 type sequence G description BINDING SITE FOR RESIDUE TFG A1410 source : AC5 21) chain A residue 168 type sequence F description BINDING SITE FOR RESIDUE TFG A1410 source : AC5 22) chain A residue 196 type sequence D description BINDING SITE FOR RESIDUE TFG A1410 source : AC5 23) chain A residue 198 type sequence H description BINDING SITE FOR RESIDUE TFG A1410 source : AC5 24) chain A residue 227 type sequence F description BINDING SITE FOR RESIDUE TFG A1410 source : AC5 25) chain A residue 290 type sequence D description BINDING SITE FOR RESIDUE TFG A1410 source : AC5 26) chain A residue 329 type sequence E description BINDING SITE FOR RESIDUE TFG A1410 source : AC5 27) chain A residue 330 type sequence G description BINDING SITE FOR RESIDUE TFG A1410 source : AC5 28) chain B residue 78 type sequence L description BINDING SITE FOR RESIDUE TFG A1410 source : AC5 29) chain B residue 79 type sequence Y description BINDING SITE FOR RESIDUE TFG A1410 source : AC5 30) chain B residue 81 type sequence T description BINDING SITE FOR RESIDUE TFG A1410 source : AC5 31) chain B residue 124 type sequence A description BINDING SITE FOR RESIDUE TFG A1410 source : AC5 32) chain A residue 196 type sequence D description BINDING SITE FOR RESIDUE ZN A1411 source : AC6 33) chain A residue 198 type sequence H description BINDING SITE FOR RESIDUE ZN A1411 source : AC6 34) chain A residue 290 type sequence D description BINDING SITE FOR RESIDUE ZN A1411 source : AC6 35) chain B residue 20 type sequence K description BINDING SITE FOR RESIDUE SO4 B1406 source : AC7 36) chain B residue 37 type sequence R description BINDING SITE FOR RESIDUE SO4 B1406 source : AC7 37) chain B residue 38 type sequence I description BINDING SITE FOR RESIDUE SO4 B1406 source : AC7 38) chain B residue 154 type sequence R description BINDING SITE FOR RESIDUE SO4 B1406 source : AC7 39) chain B residue 194 type sequence D description BINDING SITE FOR RESIDUE K B1407 source : AC8 40) chain B residue 196 type sequence D description BINDING SITE FOR RESIDUE K B1407 source : AC8 41) chain B residue 198 type sequence H description BINDING SITE FOR RESIDUE K B1407 source : AC8 42) chain B residue 217 type sequence S description BINDING SITE FOR RESIDUE K B1407 source : AC8 43) chain B residue 218 type sequence L description BINDING SITE FOR RESIDUE K B1407 source : AC8 44) chain B residue 207 type sequence F description BINDING SITE FOR RESIDUE K B1408 source : AC9 45) chain B residue 210 type sequence D description BINDING SITE FOR RESIDUE K B1408 source : AC9 46) chain B residue 213 type sequence V description BINDING SITE FOR RESIDUE K B1408 source : AC9 47) chain B residue 244 type sequence F description BINDING SITE FOR RESIDUE K B1408 source : AC9 48) chain A residue 78 type sequence L description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 49) chain A residue 79 type sequence Y description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 50) chain A residue 81 type sequence T description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 51) chain A residue 121 type sequence V description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 52) chain A residue 124 type sequence A description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 53) chain B residue 156 type sequence P description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 54) chain B residue 158 type sequence H description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 55) chain B residue 159 type sequence H description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 56) chain B residue 167 type sequence G description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 57) chain B residue 168 type sequence F description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 58) chain B residue 196 type sequence D description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 59) chain B residue 198 type sequence H description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 60) chain B residue 227 type sequence F description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 61) chain B residue 290 type sequence D description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 62) chain B residue 299 type sequence L description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 63) chain B residue 330 type sequence G description BINDING SITE FOR RESIDUE TFG B1409 source : BC1 64) chain B residue 196 type sequence D description BINDING SITE FOR RESIDUE ZN B1410 source : BC2 65) chain B residue 198 type sequence H description BINDING SITE FOR RESIDUE ZN B1410 source : BC2 66) chain B residue 290 type sequence D description BINDING SITE FOR RESIDUE ZN B1410 source : BC2 67) chain A residue 159 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 68) chain B residue 159 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1

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