eF-site ID 2vqm-A PDB Code 2vqm Chain A click to enlarge Title Structure of HDAC4 catalytic domain bound to a hydroxamic acid inhbitor Classification HYDROLASE Compound HISTONE DEACETYLASE 4 Source Homo sapiens (Human) (HDAC4_HUMAN) Sequence A:  PRFTTGLVYDTLMLKHQCTCGHAGRIQSIWSRLQETGLRG KCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKKLLG SLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVE LVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAV AAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYM SLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDP PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHP TPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTA ICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKV MEIHSKYWRCLQRTTSTAGRSLIEAQTCENE Description Functional site 1) chain A residue 194 type sequence D description BINDING SITE FOR RESIDUE K A1408 source : AC1 2) chain A residue 196 type sequence D description BINDING SITE FOR RESIDUE K A1408 source : AC1 3) chain A residue 198 type sequence H description BINDING SITE FOR RESIDUE K A1408 source : AC1 4) chain A residue 217 type sequence S description BINDING SITE FOR RESIDUE K A1408 source : AC1 5) chain A residue 218 type sequence L description BINDING SITE FOR RESIDUE K A1408 source : AC1 6) chain A residue 207 type sequence F description BINDING SITE FOR RESIDUE K A1409 source : AC2 7) chain A residue 210 type sequence D description BINDING SITE FOR RESIDUE K A1409 source : AC2 8) chain A residue 213 type sequence V description BINDING SITE FOR RESIDUE K A1409 source : AC2 9) chain A residue 244 type sequence F description BINDING SITE FOR RESIDUE K A1409 source : AC2 10) chain A residue 78 type sequence L description BINDING SITE FOR RESIDUE HA3 A1410 source : AC3 11) chain A residue 79 type sequence Y description BINDING SITE FOR RESIDUE HA3 A1410 source : AC3 12) chain A residue 121 type sequence V description BINDING SITE FOR RESIDUE HA3 A1410 source : AC3 13) chain A residue 124 type sequence A description BINDING SITE FOR RESIDUE HA3 A1410 source : AC3 14) chain A residue 156 type sequence P description BINDING SITE FOR RESIDUE HA3 A1410 source : AC3 15) chain A residue 167 type sequence G description BINDING SITE FOR RESIDUE HA3 A1410 source : AC3 16) chain A residue 168 type sequence F description BINDING SITE FOR RESIDUE HA3 A1410 source : AC3 17) chain A residue 198 type sequence H description BINDING SITE FOR RESIDUE HA3 A1410 source : AC3 18) chain A residue 227 type sequence F description BINDING SITE FOR RESIDUE HA3 A1410 source : AC3 19) chain A residue 290 type sequence D description BINDING SITE FOR RESIDUE HA3 A1410 source : AC3 20) chain A residue 330 type sequence G description BINDING SITE FOR RESIDUE HA3 A1410 source : AC3 21) chain A residue 196 type sequence D description BINDING SITE FOR RESIDUE ZN A1411 source : AC4 22) chain A residue 198 type sequence H description BINDING SITE FOR RESIDUE ZN A1411 source : AC4 23) chain A residue 290 type sequence D description BINDING SITE FOR RESIDUE ZN A1411 source : AC4 24) chain A residue 21 type sequence H description BINDING SITE FOR RESIDUE ZN A1412 source : AC5 25) chain A residue 23 type sequence C description BINDING SITE FOR RESIDUE ZN A1412 source : AC5 26) chain A residue 34 type sequence H description BINDING SITE FOR RESIDUE ZN A1412 source : AC5 27) chain A residue 107 type sequence C description BINDING SITE FOR RESIDUE ZN A1412 source : AC5 28) chain A residue 159 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 29) chain A residue 23 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 30) chain A residue 25 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 31) chain A residue 107 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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