eF-site ID 2vp0-AB
PDB Code 2vp0
Chain A, B

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Title Structural Studies of Nucleoside Analog and Feedback Inhibitor Binding to Drosophila Melanogaster Multisubstrate Deoxyribonucleoside Kinase
Classification TRANSFERASE
Compound DEOXYNUCLEOSIDE KINASE
Source Drosophila melanogaster (Fruit fly) (DNK_DROME)
Sequence A:  TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLT
EPVEKWRNVNGVNLLELMYKDPKKWAMPFQSYVTLTMLQS
HTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNT
LEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSE
ESCVPLKYLQELHELHEDWLIHQRRPQSCKVLVLDAD
B:  TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLT
EPVEKWRNVNGVNLLELMYKDPKKWAMPFQSYVTLTMLQS
HTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNT
LEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSE
ESCVPLKYLQELHELHEDWLIHQRRPQSCKVLVLDAD
Description


Functional site

1) chain A
residue 34
type
sequence T
description BINDING SITE FOR RESIDUE MG A1209
source : AC1

2) chain A
residue 52
type
sequence E
description BINDING SITE FOR RESIDUE MG A1209
source : AC1

3) chain A
residue 104
type
sequence E
description BINDING SITE FOR RESIDUE MG A1209
source : AC1

4) chain B
residue 34
type
sequence T
description BINDING SITE FOR RESIDUE MG B1209
source : AC2

5) chain B
residue 52
type
sequence E
description BINDING SITE FOR RESIDUE MG B1209
source : AC2

6) chain B
residue 104
type
sequence E
description BINDING SITE FOR RESIDUE MG B1209
source : AC2

7) chain A
residue 29
type
sequence I
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

8) chain A
residue 30
type
sequence G
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

9) chain A
residue 31
type
sequence S
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

10) chain A
residue 32
type
sequence G
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

11) chain A
residue 33
type
sequence K
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

12) chain A
residue 34
type
sequence T
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

13) chain A
residue 52
type
sequence E
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

14) chain A
residue 54
type
sequence V
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

15) chain A
residue 57
type
sequence W
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

16) chain A
residue 66
type
sequence L
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

17) chain A
residue 69
type
sequence M
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

18) chain A
residue 70
type
sequence Y
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

19) chain A
residue 80
type
sequence F
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

20) chain A
residue 81
type
sequence Q
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

21) chain A
residue 84
type
sequence V
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

22) chain A
residue 104
type
sequence E
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

23) chain A
residue 105
type
sequence R
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

24) chain A
residue 110
type
sequence A
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

25) chain A
residue 114
type
sequence F
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

26) chain A
residue 167
type
sequence R
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

27) chain A
residue 169
type
sequence R
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

28) chain A
residue 172
type
sequence E
description BINDING SITE FOR RESIDUE TTP A1210
source : AC3

29) chain B
residue 29
type
sequence I
description BINDING SITE FOR RESIDUE TTP B1210
source : AC4

30) chain B
residue 30
type
sequence G
description BINDING SITE FOR RESIDUE TTP B1210
source : AC4

31) chain B
residue 31
type
sequence S
description BINDING SITE FOR RESIDUE TTP B1210
source : AC4

32) chain B
residue 32
type
sequence G
description BINDING SITE FOR RESIDUE TTP B1210
source : AC4

33) chain B
residue 33
type
sequence K
description BINDING SITE FOR RESIDUE TTP B1210
source : AC4

34) chain B
residue 34
type
sequence T
description BINDING SITE FOR RESIDUE TTP B1210
source : AC4

35) chain B
residue 52
type
sequence E
description BINDING SITE FOR RESIDUE TTP B1210
source : AC4

36) chain B
residue 57
type
sequence W
description BINDING SITE FOR RESIDUE TTP B1210
source : AC4

37) chain B
residue 66
type
sequence L
description BINDING SITE FOR RESIDUE TTP B1210
source : AC4

38) chain B
residue 69
type
sequence M
description BINDING SITE FOR RESIDUE TTP B1210
source : AC4

39) chain B
residue 70
type
sequence Y
description BINDING SITE FOR RESIDUE TTP B1210
source : AC4

40) chain B
residue 80
type
sequence F
description BINDING SITE FOR RESIDUE TTP B1210
source : AC4

41) chain B
residue 81
type
sequence Q
description BINDING SITE FOR RESIDUE TTP B1210
source : AC4

42) chain B
residue 104
type
sequence E
description BINDING SITE FOR RESIDUE TTP B1210
source : AC4

43) chain B
residue 105
type
sequence R
description BINDING SITE FOR RESIDUE TTP B1210
source : AC4

44) chain B
residue 110
type
sequence A
description BINDING SITE FOR RESIDUE TTP B1210
source : AC4

45) chain B
residue 114
type
sequence F
description BINDING SITE FOR RESIDUE TTP B1210
source : AC4

46) chain B
residue 167
type
sequence R
description BINDING SITE FOR RESIDUE TTP B1210
source : AC4

47) chain B
residue 169
type
sequence R
description BINDING SITE FOR RESIDUE TTP B1210
source : AC4

48) chain B
residue 172
type
sequence E
description BINDING SITE FOR RESIDUE TTP B1210
source : AC4

49) chain A
residue 104
type ACT_SITE
sequence E
description Proton acceptor => ECO:0000255
source Swiss-Prot : SWS_FT_FI1

50) chain B
residue 104
type ACT_SITE
sequence E
description Proton acceptor => ECO:0000255
source Swiss-Prot : SWS_FT_FI1

51) chain A
residue 27
type BINDING
sequence G
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

52) chain B
residue 27
type BINDING
sequence G
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

53) chain A
residue 52
type BINDING
sequence E
description
source Swiss-Prot : SWS_FT_FI3

54) chain B
residue 172
type BINDING
sequence E
description
source Swiss-Prot : SWS_FT_FI3

55) chain A
residue 70
type BINDING
sequence Y
description
source Swiss-Prot : SWS_FT_FI3

56) chain A
residue 81
type BINDING
sequence Q
description
source Swiss-Prot : SWS_FT_FI3

57) chain A
residue 105
type BINDING
sequence R
description
source Swiss-Prot : SWS_FT_FI3

58) chain A
residue 172
type BINDING
sequence E
description
source Swiss-Prot : SWS_FT_FI3

59) chain B
residue 52
type BINDING
sequence E
description
source Swiss-Prot : SWS_FT_FI3

60) chain B
residue 70
type BINDING
sequence Y
description
source Swiss-Prot : SWS_FT_FI3

61) chain B
residue 81
type BINDING
sequence Q
description
source Swiss-Prot : SWS_FT_FI3

62) chain B
residue 105
type BINDING
sequence R
description
source Swiss-Prot : SWS_FT_FI3


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