|
|
eF-site ID
|
2vof-ABCD |
|
PDB Code
|
2vof |
|
Chain
|
A, B, C, D |
|
click to enlarge
|
|
|
Title
|
Structure of mouse A1 bound to the Puma BH3-domain |
|
Classification
|
APOPTOSIS |
|
Compound
|
BCL-2-RELATED PROTEIN A1 |
|
Source
|
Mus musculus (Mouse) (BBC3_MOUSE) |
|
|
Sequence
|
A: |
GSXAESELXHIHSLAEHYLQYVLQVPAFEAPSQACRVLQR
VAFSVQKEVEKNLKSYLDDFHVESIDTARIIFNQVXEKEF
EDGIINWGRIVTIFAFGGVLLKKLKQESAYKQVSSFVAEF
IXNNTGEWIRQNGGWEDGFIKKFEP
|
| B: |
EEWAREIGAQLRRIADDLNAQYE
|
| C: |
LGSXAESELXHIHSLAEHYLQYVLQVPAFEPSQACRVLQR
VAFSVQKEVEKNLKSYLDDFHVESIDTARIIFNQVXEKEF
EDGIINWGRIVTIFAFGGVLLKKLKQEQIALDVSAYKQVS
SFVAEFIXNNTGEWIRQNGGWEDGFIKKFE
|
| D: |
EWAREIGAQLRRIADDLNAQYE
|
|
|
Description
|
(1) |
BCL-2-RELATED PROTEIN A1, BCL-2-BINDING COMPONENT 3
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
10 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE CL A1151
|
| source |
: AC1
|
|
|
2)
|
chain |
C |
| residue |
7 |
| type |
|
| sequence |
X
|
| description |
BINDING SITE FOR RESIDUE CL A1151
|
| source |
: AC1
|
|
|
3)
|
chain |
C |
| residue |
10 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE CL A1151
|
| source |
: AC1
|
|
|
4)
|
chain |
C |
| residue |
85 |
| type |
|
| sequence |
N
|
| description |
BINDING SITE FOR RESIDUE CL C1150
|
| source |
: AC2
|
|
|
5)
|
chain |
C |
| residue |
86 |
| type |
|
| sequence |
W
|
| description |
BINDING SITE FOR RESIDUE CL C1150
|
| source |
: AC2
|
|
|
6)
|
chain |
D |
| residue |
149 |
| type |
|
| sequence |
N
|
| description |
BINDING SITE FOR RESIDUE CL C1150
|
| source |
: AC2
|
|
|
7)
|
chain |
A |
| residue |
78-97 |
| type |
prosite |
| sequence |
EFEDGIINWGRIVTIFAFGG
|
| description |
BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. EFeDGiiNWGRIVTIFaFGG
|
| source |
prosite : PS01080
|
|
|
8)
|
chain |
A |
| residue |
133-144 |
| type |
prosite |
| sequence |
WIRQNGGWEDGF
|
| description |
BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIrqnGGWEdGF
|
| source |
prosite : PS01258
|
|
|
|