eF-site ID 2vnf-ABCD
PDB Code 2vnf
Chain A, B, C, D

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Title MOLECULAR BASIS OF HISTONE H3K4ME3 RECOGNITION BY ING4
Classification CELL CYCLE
Compound INHIBITOR OF GROWTH PROTEIN 4
Source null (Q5TEC6_HUMAN)
Sequence A:  EPTYCLCHQVSYGEMIGCDNPDCSIEWFHFACVGLTTKPR
GKWFCPRCSQ
B:  ARTXQT
C:  VDPNEPTYCLCHQVSYGEMIGCDNPDCSIEWFHFACVGLT
TKPRGKWFCPRCSQ
D:  ARTXQTARKS
Description


Functional site
1) chain A
residue 244
type
sequence Q
description BINDING SITE FOR RESIDUE NA A 300
source : AC1
2) chain A
residue 199
type
sequence C
description BINDING SITE FOR RESIDUE DTT A 1245
source : AC2
3) chain A
residue 202
type
sequence H
description BINDING SITE FOR RESIDUE DTT A 1245
source : AC2
4) chain A
residue 219
type
sequence I
description BINDING SITE FOR RESIDUE DTT A 1245
source : AC2
5) chain C
residue 202
type
sequence H
description BINDING SITE FOR RESIDUE DTU C 1246
source : AC3
6) chain C
residue 214
type
sequence N
description BINDING SITE FOR RESIDUE DTU C 1246
source : AC3
7) chain C
residue 244
type
sequence Q
description BINDING SITE FOR RESIDUE DTU C 1246
source : AC3
8) chain A
residue 199
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1246
source : AC4
9) chain A
residue 201
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1246
source : AC4
10) chain A
residue 223
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 1246
source : AC4
11) chain A
residue 226
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1246
source : AC4
12) chain C
residue 199
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 1247
source : AC5
13) chain C
residue 201
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 1247
source : AC5
14) chain C
residue 223
type
sequence H
description BINDING SITE FOR RESIDUE ZN C 1247
source : AC5
15) chain C
residue 226
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 1247
source : AC5
16) chain C
residue 212
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 1248
source : AC6
17) chain C
residue 217
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 1248
source : AC6
18) chain C
residue 239
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 1248
source : AC6
19) chain C
residue 242
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 1248
source : AC6
20) chain A
residue 212
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1247
source : AC7
21) chain A
residue 217
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1247
source : AC7
22) chain A
residue 239
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1247
source : AC7
23) chain A
residue 242
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1247
source : AC7
24) chain A
residue 199-242
type prosite
sequence CLCHQVSYGEMIGCDNPDCSIEWFHFACVGLTTKPRGKWF
CPRC
description ZF_PHD_1 Zinc finger PHD-type signature. Cl.Chqvsygem.....................................IgCdnpdCsiewFHfaCvglttkprgk...................................WfCprC
source prosite : PS01359
25) chain D
residue 9
type MOD_RES
sequence K
description N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI7
26) chain D
residue 10
type MOD_RES
sequence S
description Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588
source Swiss-Prot : SWS_FT_FI8
27) chain B
residue 2
type MOD_RES
sequence R
description Citrulline; alternate => ECO:0000269|PubMed:16567635
source Swiss-Prot : SWS_FT_FI1
28) chain D
residue 2
type MOD_RES
sequence R
description Citrulline; alternate => ECO:0000269|PubMed:16567635
source Swiss-Prot : SWS_FT_FI1
29) chain D
residue 3
type MOD_RES
sequence T
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2
30) chain A
residue 212
type MOD_RES
sequence C
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2
31) chain C
residue 201
type MOD_RES
sequence C
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2
32) chain C
residue 212
type MOD_RES
sequence C
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2
33) chain C
residue 217
type MOD_RES
sequence C
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2
34) chain C
residue 223
type MOD_RES
sequence H
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2
35) chain C
residue 226
type MOD_RES
sequence C
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2
36) chain C
residue 239
type MOD_RES
sequence C
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2
37) chain C
residue 242
type MOD_RES
sequence C
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2
38) chain A
residue 239
type MOD_RES
sequence C
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2
39) chain A
residue 242
type MOD_RES
sequence C
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2
40) chain C
residue 199
type MOD_RES
sequence C
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2
41) chain A
residue 217
type MOD_RES
sequence C
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2
42) chain A
residue 223
type MOD_RES
sequence H
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2
43) chain A
residue 226
type MOD_RES
sequence C
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2
44) chain B
residue 3
type MOD_RES
sequence T
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2
45) chain D
residue 4
type MOD_RES
sequence X
description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI3
46) chain A
residue 213
type MOD_RES
sequence D
description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI3
47) chain A
residue 221
type MOD_RES
sequence W
description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI3
48) chain C
residue 198
type MOD_RES
sequence Y
description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI3
49) chain C
residue 209
type MOD_RES
sequence M
description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI3
50) chain C
residue 213
type MOD_RES
sequence D
description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI3
51) chain C
residue 221
type MOD_RES
sequence W
description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI3
52) chain B
residue 4
type MOD_RES
sequence X
description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI3
53) chain B
residue 5
type MOD_RES
sequence Q
description 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594
source Swiss-Prot : SWS_FT_FI4
54) chain D
residue 5
type MOD_RES
sequence Q
description 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594
source Swiss-Prot : SWS_FT_FI4
55) chain B
residue 6
type MOD_RES
sequence T
description Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790
source Swiss-Prot : SWS_FT_FI5
56) chain D
residue 6
type MOD_RES
sequence T
description Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790
source Swiss-Prot : SWS_FT_FI5
57) chain D
residue 8
type MOD_RES
sequence R
description Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433
source Swiss-Prot : SWS_FT_FI6

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