eF-site ID 2vmk-ABCD PDB Code 2vmk Chain A, B, C, D click to enlarge Title Crystal Structure of E. coli RNase E Apoprotein - Catalytic Domain Classification HYDROLASE Compound RIBONUCLEASE E Source Escherichia coli (strain K12) (RNE_ECOLI) Sequence A:  MKRMLINATQQEELRVALVDGQRLYDLDIESEQKKANIYK GKITRIEPSLEAAFVDYGAERHGFLPLKEIAREYFPRPNI KDVLREGQEVIVQIDKEERGNKGAALTTFISLAGSYLVLM PNNPRAGGISRRIRTELKEALASLELPEGMGLIVRTAGVG KSAEALQWDLSFRLKHWEAIKKAAESRPAPFLIHQESNVI VRAFRDYLRQDIGEILIDNPKVLELARQHIAALGRPDFSS KIKLYTGEIPLFSHYQIESQIESAFQREVRLPSGGSIVID STEALTAIDINSARDIEETAFNTNLEAADEIARQLRLRDL GGLIVIDFIDMTPVRHQRAVENRLREAVRQDRARIQISHI SRFGLLEMSRQRLSPSLGESSHHVCPRCSGTGTVRDNESL SLSILRLIEEEALKENTQEVHAIVPVPIASYLLNEKRSAV NAIETRQDGVRCVIVPNDQMETPHYHVLRVRKGEETPTLS YMLPKLHEE B:  MKRMLINATLRVALVDGQRLYDLDIHEQKKANIYKGKITR IEPSLEAAFVDYGAERHGFLPLKEIAREYFPARPNIKDVL REGQEVIVQIDKEERGNKGAALTTFISLAGSYLVLMPNNP RAGGISRRIEGDDRTELKEALASLELPEGMGLIVRTAGVG KSAEALQWDLSFRLKHWEAIKKAAESRPAPFLIHQESNVI VRAFRDYLRQDIGEILIDNPKVLELARQHIAALGRPDFSS KIKLYTGEIPLFSHYQIESQIESAFQREVRLPSGGSIVID STEALTAIDINSARGDIEETAFNTNLEAADEIARQLRLRD LGGLIVIDFIDMTPVRHQRAVENRLREAVRQDRARIQISH ISRFGLLEMSRQRLSPSLGESSHHVCPRCSGTGTVRDNES LSLSILRLIEEEALKENTQEVHAIVPVPIASYLLNEKRSA VNAIETRQDGVRCVIVPNDQMETPHYHVLRVRKGEETPTL SYMLPKLHEEAMALP C:  MKRMLINATQQLRVALVDGQRLYDLDIESPGKKANIYKGK ITRIEPSLEAAFVDYGAERHGFLPLKEIAREYFRPNIKDV LREGQEVIVQIDKEERGNKGAALTTFISLAGSYLVLMPNN PRAGGISRTELKEALASLELPEGMGLIVRTAGVGKSAEAL QWDLSFRLKHWEAIKKAAESRPAPFLIHQESNVIVRAFRD YLRQDIGEILIDNPKVLELARQHIAALGRPDFSSKIKLYT GEIPLFSHYQIESQIESAFQREVRLPSGGSIVIDSTEALT AIDINSAGDIEETAFNTNLEAADEIARQLRLRDLGGLIVI DFIDMTPVRHQRAVENRLREAVRQDRARIQISHISRFGLL EMSRQRLSHHVCPRCSGTGTVRDNESLSLSILRLIEEEAL KENTQEVHAIVPVPIASYLLNEKRSAVNAIETRQDGVRCV IVPNDQMETPHYHVLRVRKGEETPTLSYMLPKLH D:  MKRMLINATLRVALVDGQRLYDLDIQKKANIYKGKITRIE PSLEAAFVDAERHGFLPLKEIAREYFPRPNIKDVLREGQE VIVQIDKEERALTTFISLAGSYLVLMPNNPRAGGDDRTEL KEALASLELPEGMGLIVRTASAEALQWDLSFRLKHWEAIK KAAESRPAPFLIHQESNVIVRAFRDYLRQDIGEILIDNPK VLELARQHIAALGRPDFSSKIKLYTGEIPLFSHYQIESQI ESAFQREVRLPSGGSIVIDSTEALTAIDINSADIEETAFN TNLEAADEIARQLRLRDLGGLIVIDFIDMTPVRHQRAVEN RLREAVRQDRARIQISHISRFGLLEMSRQRLSLGESSHHV CPRCSGTGTVRDNESLSLSILRLIEEEALKENTQEVHAIV PVPIASYLLNEKRSAVNAIETRQDGVRCVIVPNDQMETPH YHVLRVRKGEETPTLSYMLPKLHEEAMALPSE Description Functional site 1) chain A residue 404 type sequence C description BINDING SITE FOR RESIDUE ZN B1514 source : AC1 2) chain A residue 407 type sequence C description BINDING SITE FOR RESIDUE ZN B1514 source : AC1 3) chain B residue 404 type sequence C description BINDING SITE FOR RESIDUE ZN B1514 source : AC1 4) chain B residue 407 type sequence C description BINDING SITE FOR RESIDUE ZN B1514 source : AC1 5) chain C residue 404 type sequence C description BINDING SITE FOR RESIDUE ZN D1516 source : AC2 6) chain C residue 407 type sequence C description BINDING SITE FOR RESIDUE ZN D1516 source : AC2 7) chain D residue 404 type sequence C description BINDING SITE FOR RESIDUE ZN D1516 source : AC2 8) chain D residue 407 type sequence C description BINDING SITE FOR RESIDUE ZN D1516 source : AC2 9) chain A residue 140 type sequence S description BINDING SITE FOR RESIDUE SO4 A1509 source : AC3 10) chain A residue 169 type sequence R description BINDING SITE FOR RESIDUE SO4 A1509 source : AC3 11) chain A residue 170 type sequence T description BINDING SITE FOR RESIDUE SO4 A1509 source : AC3 12) chain B residue 170 type sequence T description BINDING SITE FOR RESIDUE SO4 B1515 source : AC4 13) chain C residue 169 type sequence R description BINDING SITE FOR RESIDUE SO4 C1507 source : AC5 14) chain C residue 170 type sequence T description BINDING SITE FOR RESIDUE SO4 C1507 source : AC5 15) chain C residue 171 type sequence A description BINDING SITE FOR RESIDUE SO4 C1507 source : AC5 16) chain A residue 303 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16237448 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 346 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16237448 source Swiss-Prot : SWS_FT_FI1 18) chain B residue 303 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16237448 source Swiss-Prot : SWS_FT_FI1 19) chain B residue 346 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16237448 source Swiss-Prot : SWS_FT_FI1 20) chain C residue 303 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16237448 source Swiss-Prot : SWS_FT_FI1 21) chain C residue 346 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16237448 source Swiss-Prot : SWS_FT_FI1 22) chain D residue 303 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16237448 source Swiss-Prot : SWS_FT_FI1 23) chain D residue 346 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16237448 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 404 type BINDING sequence C description BINDING => ECO:0000269|PubMed:15779893, ECO:0000269|PubMed:18682225 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 407 type BINDING sequence C description BINDING => ECO:0000269|PubMed:15779893, ECO:0000269|PubMed:18682225 source Swiss-Prot : SWS_FT_FI2 26) chain B residue 404 type BINDING sequence C description BINDING => ECO:0000269|PubMed:15779893, ECO:0000269|PubMed:18682225 source Swiss-Prot : SWS_FT_FI2 27) chain B residue 407 type BINDING sequence C description BINDING => ECO:0000269|PubMed:15779893, ECO:0000269|PubMed:18682225 source Swiss-Prot : SWS_FT_FI2 28) chain C residue 404 type BINDING sequence C description BINDING => ECO:0000269|PubMed:15779893, ECO:0000269|PubMed:18682225 source Swiss-Prot : SWS_FT_FI2 29) chain C residue 407 type BINDING sequence C description BINDING => ECO:0000269|PubMed:15779893, ECO:0000269|PubMed:18682225 source Swiss-Prot : SWS_FT_FI2 30) chain D residue 404 type BINDING sequence C description BINDING => ECO:0000269|PubMed:15779893, ECO:0000269|PubMed:18682225 source Swiss-Prot : SWS_FT_FI2 31) chain D residue 407 type BINDING sequence C description BINDING => ECO:0000269|PubMed:15779893, ECO:0000269|PubMed:18682225 source Swiss-Prot : SWS_FT_FI2

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