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eF-site ID
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2vlr-ABCDEFGHIJ |
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PDB Code
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2vlr |
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Chain
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A, B, C, D, E, F, G, H, I, J |
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click to enlarge
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Title
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The Structural Dynamics and Energetics of an Immunodominant T-cell Receptor are Programmed by its Vbeta Domain |
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Classification
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IMMUNE SYSTEM |
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Compound
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HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN |
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Source
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(2VLR) |
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Sequence
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A: |
GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDA
ASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGT
LRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDG
KDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAYL
EGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEAT
LRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEP
|
| B: |
MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDL
LKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYA
CRVNHVTLSQPKIVKWDRDM
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| C: |
GILGFVFTL
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| D: |
QLLEQSPQFLSIQEGENLTVYCNSSSVFSSLQWYRQEPGE
GPVLLVTVVTGGEVKKLKRLTFQFGDARKDSSLHITAAQP
GDTGLYLCAGAGSQGNLIFGKGTKLSVKPNIQNPDPAVYQ
LRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLD
MRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPS
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| E: |
GITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQG
LRLIYYSQIVNDFQKGDIAEGYSVSREKKESFPLTVTSAQ
KNPTAFYLCASSSRASYEQYFGPGTRLTVTEDLKNVFPPE
VAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGK
EVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNP
RNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD
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| F: |
GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDA
ASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGT
LRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDG
KDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAYL
EGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEAT
LRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEP
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| G: |
MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDL
LKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYA
CRVNHVTLSQPKIVKWDRDM
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| H: |
GILGFVFTL
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| I: |
QLLEQSPQFLSIQEGENLTVYCNSSSVFSSLQWYRQEPGE
GPVLLVTVVTGGEVKKLKRLTFQFGDARKDSSLHITAAQP
GDTGLYLCAGAGSQGNLIFGKGTKLSVKPNIQNPDPAVYQ
LRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLD
MRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPS
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| J: |
GITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQG
LRLIYYSQIVNDFQKGDIAEGYSVSREKKESFPLTVTSAQ
KNPTAFYLCASSSRASYEQYFGPGTRLTVTEDLKNVFPPE
VAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGK
EVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNP
RNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD
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Description
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(1) |
HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN, BETA-2-MICROGLOBULIN, FLU MATRIX PEPTIDE, JM22 TCR ALPHA CHAIN, JM22 TCR BETA CHAIN
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1)
|
chain |
A |
| residue |
257-263 |
| type |
prosite |
| sequence |
YTCHVQH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH
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| source |
prosite : PS00290
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|
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2)
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chain |
B |
| residue |
78-84 |
| type |
prosite |
| sequence |
YACRVNH
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| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH
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| source |
prosite : PS00290
|
|
|
3)
|
chain |
B |
| residue |
2 |
| type |
MOD_RES |
| sequence |
Q
|
| description |
Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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4)
|
chain |
F |
| residue |
143 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
F |
| residue |
146 |
| type |
MOD_RES |
| sequence |
K
|
| description |
Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
6)
|
chain |
F |
| residue |
171 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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7)
|
chain |
G |
| residue |
2 |
| type |
MOD_RES |
| sequence |
Q
|
| description |
Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
8)
|
chain |
A |
| residue |
84 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
9)
|
chain |
A |
| residue |
143 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
10)
|
chain |
A |
| residue |
146 |
| type |
MOD_RES |
| sequence |
K
|
| description |
Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
11)
|
chain |
A |
| residue |
171 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
12)
|
chain |
F |
| residue |
7 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
13)
|
chain |
F |
| residue |
73 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
14)
|
chain |
F |
| residue |
84 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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15)
|
chain |
B |
| residue |
1 |
| type |
CARBOHYD |
| sequence |
I
|
| description |
N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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16)
|
chain |
G |
| residue |
1 |
| type |
CARBOHYD |
| sequence |
I
|
| description |
N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
17)
|
chain |
F |
| residue |
116 |
| type |
CARBOHYD |
| sequence |
Y
|
| description |
N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
18)
|
chain |
F |
| residue |
159 |
| type |
CARBOHYD |
| sequence |
Y
|
| description |
N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
19)
|
chain |
B |
| residue |
19 |
| type |
CARBOHYD |
| sequence |
K
|
| description |
N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
20)
|
chain |
G |
| residue |
58 |
| type |
CARBOHYD |
| sequence |
K
|
| description |
N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
21)
|
chain |
G |
| residue |
91 |
| type |
CARBOHYD |
| sequence |
K
|
| description |
N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
22)
|
chain |
G |
| residue |
94 |
| type |
CARBOHYD |
| sequence |
K
|
| description |
N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
23)
|
chain |
B |
| residue |
41 |
| type |
CARBOHYD |
| sequence |
K
|
| description |
N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
24)
|
chain |
B |
| residue |
48 |
| type |
CARBOHYD |
| sequence |
K
|
| description |
N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
25)
|
chain |
B |
| residue |
58 |
| type |
CARBOHYD |
| sequence |
K
|
| description |
N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
26)
|
chain |
B |
| residue |
91 |
| type |
CARBOHYD |
| sequence |
K
|
| description |
N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
27)
|
chain |
B |
| residue |
94 |
| type |
CARBOHYD |
| sequence |
K
|
| description |
N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
28)
|
chain |
G |
| residue |
19 |
| type |
CARBOHYD |
| sequence |
K
|
| description |
N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
29)
|
chain |
G |
| residue |
41 |
| type |
CARBOHYD |
| sequence |
K
|
| description |
N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
30)
|
chain |
G |
| residue |
48 |
| type |
CARBOHYD |
| sequence |
K
|
| description |
N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
31)
|
chain |
A |
| residue |
86 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
32)
|
chain |
F |
| residue |
86 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|