eF-site ID 2vjx-B PDB Code 2vjx Chain B click to enlarge Title Structural and biochemical evidence for a boat-like transition state in beta-mannosidases Classification HYDROLASE Compound BETA-MANNOSIDASE Source (2VJX) Sequence B:  NDTSEVMLLDTGWEFSQSGTEKWMPATVPGTVHQDLISHE LLPNPFYGMNEKKIQWVENEDWEYRTSFIVSEEQLNRDGI QLIFEGLDTYADVYLNGSLLLKADNMFVGYTLPVKSVLRK GENHLYIYFHSPIRQTLPQYASNGFNYPADNDHHEKHLSV FSRKAPYSYGWDWGIRMVTSGVWRPVTLRFYDIATISDYY VRQLSLTDENARLSNELIVNQIVPQKIPAEVRVNVSLNGT TVTEVKQQVTLQPGINHITLPAEVTNPVRWMPNGWGTPTL YDFSAQIACGDRIVAEQSHRIGLRTIRVVNEKDKDGESFY FEVNGIPMFAKGANYIPQDALLPNVTTERYQTLFRDMKEA NMNMVRIWGGGTYENNLFYDLADENGILVWQDFMFACTPY PSDPTFLKRVEAEAVYNIRRLRNHASLAMWCGNNEILEAL KYWGFEKKFTPEVYQGLMHGYDKLFRELLPSTVKEFDSDR FYVHSSPYLANWGRPESWGTGDSHNWGVWYGKKPFESLDT DLPRFMSEFGFQSFPEMKTIAAFAAPEDYQIESEVMNAHQ KSSIGNSLIRTYMERDYIIPESFEDFVYVGLVLQGQGMRH GLEAHRRNRPYCMGTLYWQLNDSWPVVSWSSIDYYGNWKA LHYQAKRAFAPVLINPIQQNDSLSVYLISDRLDTMEQMTL EMKVVDFDGKTLGKKIQVHSLEVPANTSKCVYRAKLDGWL TPEDCRRSFLKLILKDKSGHQVAESVHFFRKTKDLQLPPT SVSYQMKQTDGKCELTLFSSMLAKDIFIETPLQGARYSDN FFDLLPGERKKVIITSPRIKKGEELPVNIKHIRETYKEH Description Functional site 1) chain B residue 198 type sequence W description BINDING SITE FOR RESIDUE IFL B1867 source : AC2 2) chain B residue 199 type sequence D description BINDING SITE FOR RESIDUE IFL B1867 source : AC2 3) chain B residue 200 type sequence W description BINDING SITE FOR RESIDUE IFL B1867 source : AC2 4) chain B residue 395 type sequence W description BINDING SITE FOR RESIDUE IFL B1867 source : AC2 5) chain B residue 424 type sequence C description BINDING SITE FOR RESIDUE IFL B1867 source : AC2 6) chain B residue 461 type sequence N description BINDING SITE FOR RESIDUE IFL B1867 source : AC2 7) chain B residue 462 type sequence E description BINDING SITE FOR RESIDUE IFL B1867 source : AC2 8) chain B residue 533 type sequence W description BINDING SITE FOR RESIDUE IFL B1867 source : AC2 9) chain B residue 537 type sequence Y description BINDING SITE FOR RESIDUE IFL B1867 source : AC2 10) chain B residue 555 type sequence E description BINDING SITE FOR RESIDUE IFL B1867 source : AC2 11) chain B residue 645 type sequence W description BINDING SITE FOR RESIDUE IFL B1867 source : AC2 12) chain B residue 525 type sequence W description BINDING SITE FOR RESIDUE EDO B1868 source : AC4 13) chain B residue 530 type sequence S description BINDING SITE FOR RESIDUE EDO B1868 source : AC4 14) chain B residue 532 type sequence N description BINDING SITE FOR RESIDUE EDO B1868 source : AC4 15) chain B residue 548 type sequence D description BINDING SITE FOR RESIDUE EDO B1868 source : AC4 16) chain B residue 549 type sequence L description BINDING SITE FOR RESIDUE EDO B1868 source : AC4 17) chain B residue 550 type sequence P description BINDING SITE FOR RESIDUE EDO B1868 source : AC4 18) chain B residue 553 type sequence M description BINDING SITE FOR RESIDUE EDO B1868 source : AC4 19) chain B residue 337 type sequence N description BINDING SITE FOR RESIDUE EDO B1869 source : BC2 20) chain B residue 510 type sequence V description BINDING SITE FOR RESIDUE EDO B1869 source : BC2 21) chain B residue 511 type sequence H description BINDING SITE FOR RESIDUE EDO B1869 source : BC2 22) chain B residue 515 type sequence Y description BINDING SITE FOR RESIDUE EDO B1869 source : BC2 23) chain B residue 88 type sequence D description BINDING SITE FOR RESIDUE EDO B1870 source : BC3 24) chain B residue 157 type sequence H description BINDING SITE FOR RESIDUE EDO B1870 source : BC3 25) chain B residue 162 type sequence Q description BINDING SITE FOR RESIDUE EDO B1870 source : BC3 26) chain B residue 126 type sequence L description BINDING SITE FOR RESIDUE EDO B1871 source : BC5 27) chain B residue 127 type sequence L description BINDING SITE FOR RESIDUE EDO B1871 source : BC5 28) chain B residue 129 type sequence K description BINDING SITE FOR RESIDUE EDO B1871 source : BC5 29) chain B residue 43 type sequence S description BINDING SITE FOR RESIDUE EDO B1872 source : BC8 30) chain B residue 44 type sequence Q description BINDING SITE FOR RESIDUE EDO B1872 source : BC8 31) chain B residue 45 type sequence S description BINDING SITE FOR RESIDUE EDO B1872 source : BC8 32) chain B residue 46 type sequence G description BINDING SITE FOR RESIDUE EDO B1872 source : BC8 33) chain B residue 47 type sequence T description BINDING SITE FOR RESIDUE EDO B1872 source : BC8 34) chain B residue 48 type sequence E description BINDING SITE FOR RESIDUE EDO B1872 source : BC8 35) chain B residue 90 type sequence E description BINDING SITE FOR RESIDUE EDO B1872 source : BC8 36) chain B residue 129 type sequence K description BINDING SITE FOR RESIDUE EDO A1876 source : BC9 37) chain B residue 542 type sequence F description BINDING SITE FOR RESIDUE EDO B1873 source : CC1 38) chain B residue 543 type sequence E description BINDING SITE FOR RESIDUE EDO B1873 source : CC1 39) chain B residue 603 type sequence D description BINDING SITE FOR RESIDUE EDO B1873 source : CC1 40) chain B residue 624 type sequence G description BINDING SITE FOR RESIDUE EDO B1873 source : CC1 41) chain B residue 331 type sequence R description BINDING SITE FOR RESIDUE EDO B1874 source : CC3 42) chain B residue 506 type sequence D description BINDING SITE FOR RESIDUE EDO B1874 source : CC3 43) chain B residue 507 type sequence R description BINDING SITE FOR RESIDUE EDO B1874 source : CC3 44) chain B residue 365 type sequence Q description BINDING SITE FOR RESIDUE EDO B1875 source : CC6 45) chain B residue 648 type sequence N description BINDING SITE FOR RESIDUE EDO B1875 source : CC6 46) chain B residue 649 type sequence D description BINDING SITE FOR RESIDUE EDO B1875 source : CC6 47) chain B residue 659 type sequence I description BINDING SITE FOR RESIDUE EDO B1875 source : CC6 48) chain B residue 660 type sequence D description BINDING SITE FOR RESIDUE EDO B1875 source : CC6 49) chain B residue 465 type sequence E description BINDING SITE FOR RESIDUE EDO B1876 source : CC7 50) chain B residue 468 type sequence K description BINDING SITE FOR RESIDUE EDO B1876 source : CC7 51) chain B residue 469 type sequence Y description BINDING SITE FOR RESIDUE EDO B1876 source : CC7 52) chain B residue 514 type sequence P description BINDING SITE FOR RESIDUE EDO B1876 source : CC7 53) chain B residue 516 type sequence L description BINDING SITE FOR RESIDUE EDO B1876 source : CC7 54) chain B residue 517 type sequence A description BINDING SITE FOR RESIDUE EDO B1876 source : CC7 55) chain B residue 178 type sequence N description BINDING SITE FOR RESIDUE EDO B1877 source : CC8 56) chain B residue 199 type sequence D description BINDING SITE FOR RESIDUE EDO B1877 source : CC8 57) chain B residue 424 type sequence C description BINDING SITE FOR RESIDUE EDO B1877 source : CC8 58) chain B residue 462 type sequence E description BINDING SITE FOR RESIDUE EDO B1877 source : CC8 59) chain B residue 470 type sequence W description BINDING SITE FOR RESIDUE EDO B1877 source : CC8 60) chain B residue 155 type sequence Y description BINDING SITE FOR RESIDUE EDO A1880 source : CC9 61) chain B residue 157 type sequence H description BINDING SITE FOR RESIDUE EDO A1880 source : CC9 62) chain B residue 356 type sequence F description BINDING SITE FOR RESIDUE EDO B1878 source : DC4 63) chain B residue 633 type sequence R description BINDING SITE FOR RESIDUE EDO B1878 source : DC4 64) chain B residue 636 type sequence R description BINDING SITE FOR RESIDUE EDO B1878 source : DC4 65) chain B residue 695 type sequence I description BINDING SITE FOR RESIDUE EDO B1878 source : DC4 66) chain B residue 696 type sequence S description BINDING SITE FOR RESIDUE EDO B1878 source : DC4 67) chain B residue 697 type sequence D description BINDING SITE FOR RESIDUE EDO B1878 source : DC4 68) chain B residue 733 type sequence N description BINDING SITE FOR RESIDUE EDO B1878 source : DC4 69) chain B residue 734 type sequence T description BINDING SITE FOR RESIDUE EDO B1878 source : DC4 70) chain B residue 328 type sequence I description BINDING SITE FOR RESIDUE EDO B1879 source : DC8 71) chain B residue 329 type sequence G description BINDING SITE FOR RESIDUE EDO B1879 source : DC8 72) chain B residue 449 type sequence R description BINDING SITE FOR RESIDUE EDO B1879 source : DC8 73) chain B residue 450 type sequence N description BINDING SITE FOR RESIDUE EDO B1879 source : DC8 74) chain B residue 451 type sequence H description BINDING SITE FOR RESIDUE EDO B1879 source : DC8 75) chain B residue 452 type sequence A description BINDING SITE FOR RESIDUE EDO B1879 source : DC8 76) chain B residue 507 type sequence R description BINDING SITE FOR RESIDUE EDO B1879 source : DC8 77) chain B residue 819 type sequence L description BINDING SITE FOR RESIDUE EDO B1880 source : EC1 78) chain B residue 820 type sequence Q description BINDING SITE FOR RESIDUE EDO B1880 source : EC1 79) chain B residue 845 type sequence R description BINDING SITE FOR RESIDUE EDO B1880 source : EC1 80) chain B residue 775 type sequence F description BINDING SITE FOR RESIDUE EDO B1881 source : EC2 81) chain B residue 777 type sequence R description BINDING SITE FOR RESIDUE EDO B1881 source : EC2 82) chain B residue 119 type sequence D description BINDING SITE FOR RESIDUE EDO A1888 source : EC3 83) chain B residue 121 type sequence Y description BINDING SITE FOR RESIDUE EDO A1888 source : EC3 84) chain B residue 155 type sequence Y description BINDING SITE FOR RESIDUE EDO A1888 source : EC3 85) chain B residue 42 type sequence F description BINDING SITE FOR RESIDUE EDO B1882 source : EC4 86) chain B residue 43 type sequence S description BINDING SITE FOR RESIDUE EDO B1882 source : EC4 87) chain B residue 44 type sequence Q description BINDING SITE FOR RESIDUE EDO B1882 source : EC4 88) chain B residue 47 type sequence T description BINDING SITE FOR RESIDUE EDO B1882 source : EC4 89) chain B residue 49 type sequence K description BINDING SITE FOR RESIDUE EDO B1882 source : EC4 90) chain B residue 51 type sequence M description BINDING SITE FOR RESIDUE EDO B1882 source : EC4 91) chain B residue 68 type sequence L description BINDING SITE FOR RESIDUE EDO B1882 source : EC4 92) chain B residue 212 type sequence P description BINDING SITE FOR RESIDUE EDO B1883 source : EC5 93) chain B residue 382 type sequence R description BINDING SITE FOR RESIDUE EDO B1884 source : EC7 94) chain B residue 823 type sequence R description BINDING SITE FOR RESIDUE EDO B1884 source : EC7 95) chain B residue 825 type sequence S description BINDING SITE FOR RESIDUE EDO B1884 source : EC7 96) chain B residue 840 type sequence I description BINDING SITE FOR RESIDUE EDO B1884 source : EC7 97) chain B residue 842 type sequence T description BINDING SITE FOR RESIDUE EDO B1884 source : EC7 98) chain B residue 161 type sequence R description BINDING SITE FOR RESIDUE EDO B1885 source : EC9 99) chain B residue 162 type sequence Q description BINDING SITE FOR RESIDUE EDO B1885 source : EC9 100) chain B residue 165 type sequence P description BINDING SITE FOR RESIDUE EDO B1885 source : EC9 101) chain B residue 107 type sequence I description BINDING SITE FOR RESIDUE BR B1886 source : FC2 102) chain B residue 142 type sequence K description BINDING SITE FOR RESIDUE BR B1886 source : FC2 103) chain B residue 129 type sequence K description BINDING SITE FOR RESIDUE BR A1893 source : FC4 104) chain B residue 157 type sequence H description BINDING SITE FOR RESIDUE BR A1893 source : FC4 105) chain B residue 162 type sequence Q description BINDING SITE FOR RESIDUE BR A1893 source : FC4 106) chain B residue 685 type sequence Q description BINDING SITE FOR RESIDUE BR B1887 source : FC6 107) chain B residue 688 type sequence D description BINDING SITE FOR RESIDUE BR B1887 source : FC6 108) chain B residue 108 type sequence Q description BINDING SITE FOR RESIDUE CL B1888 source : FC7 109) chain B residue 685 type sequence Q description BINDING SITE FOR RESIDUE CL B1889 source : FC8 110) chain B residue 774 type sequence H description BINDING SITE FOR RESIDUE CL B1889 source : FC8 111) chain B residue 300 type sequence N description BINDING SITE FOR RESIDUE CL B1890 source : GC4 112) chain B residue 390 type sequence N description BINDING SITE FOR RESIDUE CL B1890 source : GC4 113) chain B residue 131 type sequence D description BINDING SITE FOR RESIDUE CL B1891 source : GC5 114) chain B residue 132 type sequence N description BINDING SITE FOR RESIDUE CL B1891 source : GC5 115) chain B residue 436 type sequence R description BINDING SITE FOR RESIDUE CL B1891 source : GC5 116) chain B residue 376 type sequence R description BINDING SITE FOR RESIDUE EDO B1892 source : GC9 117) chain B residue 661 type sequence Y description BINDING SITE FOR RESIDUE EDO B1892 source : GC9 118) chain B residue 597 type sequence R description BINDING SITE FOR RESIDUE EDO B1893 source : HC1 119) chain B residue 607 type sequence P description BINDING SITE FOR RESIDUE EDO B1893 source : HC1 120) chain B residue 608 type sequence E description BINDING SITE FOR RESIDUE EDO B1893 source : HC1 121) chain B residue 609 type sequence S description BINDING SITE FOR RESIDUE EDO B1893 source : HC1 122) chain B residue 613 type sequence F description BINDING SITE FOR RESIDUE EDO B1893 source : HC1 123) chain B residue 623 type sequence Q description BINDING SITE FOR RESIDUE EDO B1894 source : HC2 124) chain B residue 626 type sequence R description BINDING SITE FOR RESIDUE EDO B1894 source : HC2 125) chain B residue 774 type sequence H description BINDING SITE FOR RESIDUE EDO B1894 source : HC2 126) chain B residue 775 type sequence F description BINDING SITE FOR RESIDUE EDO B1894 source : HC2

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