eF-site ID 2vjx-A PDB Code 2vjx Chain A click to enlarge Title Structural and biochemical evidence for a boat-like transition state in beta-mannosidases Classification HYDROLASE Compound BETA-MANNOSIDASE Source (2VJX) Sequence A:  NDTSEVMLLDTGWEFSQSGTEKWMPATVPGTVHQDLISHE LLPNPFYGMNEKKIQWVENEDWEYRTSFIVSEEQLNRDGI QLIFEGLDTYADVYLNGSLLLKADNMFVGYTLPVKSVLRK GENHLYIYFHSPIRQTLPQYASNGFNYPADNDHHEKHLSV FSRKAPYSYGWDWGIRMVTSGVWRPVTLRFYDIATISDYY VRQLSLTDENARLSNELIVNQIVPQKIPAEVRVNVSLNGT TVTEVKQQVTLQPGINHITLPAEVTNPVRWMPNGWGTPTL YDFSAQIACGRIVAEQSHRIGLRTIRVVNEKDKDGESFYF EVNGIPMFAKGANYIPQDALLPNVTTERYQTLFRDMKEAN MNMVRIWGGGTYENNLFYDLADENGILVWQDFMFACTPYP SDPTFLKRVEAEAVYNIRRLRNHASLAMWCGNNEILEALK YWGFEKKFTPEVYQGLMHGYDKLFRELLPSTVKEFDSDRF YVHSSPYLANWGRPESWGTGDSHNWGVWYGKKPFESLDTD LPRFMSEFGFQSFPEMKTIAAFAAPEDYQIESEVMNAHQK SSIGNSLIRTYMERDYIIPESFEDFVYVGLVLQGQGMRHG LEAHRRNRPYCMGTLYWQLNDSWPVVSWSSIDYYGNWKAL HYQAKRAFAPVLINPIQQNDSLSVYLISDRLDTMEQMTLE MKVVDFDGKTLGKKIQVHSLEVPANTSKCVYRAKLDGWLT PEDCRRSFLKLILKDKSGHQVAESVHFFRKTKDLQLPPTS VSYQMKQTDGKCELTLFSSMLAKDIFIETPLQGARYSDNF FDLLPGERKKVIITSPRIKKGEELPVNIKHIRETYK Description Functional site 1) chain A residue 198 type sequence W description BINDING SITE FOR RESIDUE IFL A1865 source : AC1 2) chain A residue 199 type sequence D description BINDING SITE FOR RESIDUE IFL A1865 source : AC1 3) chain A residue 200 type sequence W description BINDING SITE FOR RESIDUE IFL A1865 source : AC1 4) chain A residue 395 type sequence W description BINDING SITE FOR RESIDUE IFL A1865 source : AC1 5) chain A residue 424 type sequence C description BINDING SITE FOR RESIDUE IFL A1865 source : AC1 6) chain A residue 461 type sequence N description BINDING SITE FOR RESIDUE IFL A1865 source : AC1 7) chain A residue 462 type sequence E description BINDING SITE FOR RESIDUE IFL A1865 source : AC1 8) chain A residue 533 type sequence W description BINDING SITE FOR RESIDUE IFL A1865 source : AC1 9) chain A residue 537 type sequence Y description BINDING SITE FOR RESIDUE IFL A1865 source : AC1 10) chain A residue 555 type sequence E description BINDING SITE FOR RESIDUE IFL A1865 source : AC1 11) chain A residue 645 type sequence W description BINDING SITE FOR RESIDUE IFL A1865 source : AC1 12) chain A residue 656 type sequence W description BINDING SITE FOR RESIDUE IFL A1865 source : AC1 13) chain A residue 365 type sequence Q description BINDING SITE FOR RESIDUE EDO A1866 source : AC3 14) chain A residue 648 type sequence N description BINDING SITE FOR RESIDUE EDO A1866 source : AC3 15) chain A residue 649 type sequence D description BINDING SITE FOR RESIDUE EDO A1866 source : AC3 16) chain A residue 659 type sequence I description BINDING SITE FOR RESIDUE EDO A1866 source : AC3 17) chain A residue 660 type sequence D description BINDING SITE FOR RESIDUE EDO A1866 source : AC3 18) chain A residue 519 type sequence W description BINDING SITE FOR RESIDUE EDO A1867 source : AC5 19) chain A residue 525 type sequence W description BINDING SITE FOR RESIDUE EDO A1867 source : AC5 20) chain A residue 530 type sequence S description BINDING SITE FOR RESIDUE EDO A1867 source : AC5 21) chain A residue 532 type sequence N description BINDING SITE FOR RESIDUE EDO A1867 source : AC5 22) chain A residue 548 type sequence D description BINDING SITE FOR RESIDUE EDO A1867 source : AC5 23) chain A residue 549 type sequence L description BINDING SITE FOR RESIDUE EDO A1867 source : AC5 24) chain A residue 550 type sequence P description BINDING SITE FOR RESIDUE EDO A1867 source : AC5 25) chain A residue 553 type sequence M description BINDING SITE FOR RESIDUE EDO A1867 source : AC5 26) chain A residue 328 type sequence I description BINDING SITE FOR RESIDUE EDO A1868 source : AC6 27) chain A residue 329 type sequence G description BINDING SITE FOR RESIDUE EDO A1868 source : AC6 28) chain A residue 449 type sequence R description BINDING SITE FOR RESIDUE EDO A1868 source : AC6 29) chain A residue 450 type sequence N description BINDING SITE FOR RESIDUE EDO A1868 source : AC6 30) chain A residue 451 type sequence H description BINDING SITE FOR RESIDUE EDO A1868 source : AC6 31) chain A residue 452 type sequence A description BINDING SITE FOR RESIDUE EDO A1868 source : AC6 32) chain A residue 507 type sequence R description BINDING SITE FOR RESIDUE EDO A1868 source : AC6 33) chain A residue 331 type sequence R description BINDING SITE FOR RESIDUE EDO A1869 source : AC7 34) chain A residue 507 type sequence R description BINDING SITE FOR RESIDUE EDO A1869 source : AC7 35) chain A residue 465 type sequence E description BINDING SITE FOR RESIDUE EDO A1870 source : AC8 36) chain A residue 468 type sequence K description BINDING SITE FOR RESIDUE EDO A1870 source : AC8 37) chain A residue 469 type sequence Y description BINDING SITE FOR RESIDUE EDO A1870 source : AC8 38) chain A residue 514 type sequence P description BINDING SITE FOR RESIDUE EDO A1870 source : AC8 39) chain A residue 516 type sequence L description BINDING SITE FOR RESIDUE EDO A1870 source : AC8 40) chain A residue 517 type sequence A description BINDING SITE FOR RESIDUE EDO A1870 source : AC8 41) chain A residue 518 type sequence N description BINDING SITE FOR RESIDUE EDO A1870 source : AC8 42) chain A residue 597 type sequence R description BINDING SITE FOR RESIDUE EDO A1871 source : AC9 43) chain A residue 607 type sequence P description BINDING SITE FOR RESIDUE EDO A1871 source : AC9 44) chain A residue 608 type sequence E description BINDING SITE FOR RESIDUE EDO A1871 source : AC9 45) chain A residue 609 type sequence S description BINDING SITE FOR RESIDUE EDO A1871 source : AC9 46) chain A residue 613 type sequence F description BINDING SITE FOR RESIDUE EDO A1871 source : AC9 47) chain A residue 337 type sequence N description BINDING SITE FOR RESIDUE EDO A1872 source : BC1 48) chain A residue 515 type sequence Y description BINDING SITE FOR RESIDUE EDO A1872 source : BC1 49) chain A residue 155 type sequence Y description BINDING SITE FOR RESIDUE EDO B1870 source : BC3 50) chain A residue 157 type sequence H description BINDING SITE FOR RESIDUE EDO B1870 source : BC3 51) chain A residue 623 type sequence Q description BINDING SITE FOR RESIDUE EDO A1873 source : BC4 52) chain A residue 626 type sequence R description BINDING SITE FOR RESIDUE EDO A1873 source : BC4 53) chain A residue 774 type sequence H description BINDING SITE FOR RESIDUE EDO A1873 source : BC4 54) chain A residue 775 type sequence F description BINDING SITE FOR RESIDUE EDO A1873 source : BC4 55) chain A residue 432 type sequence T description BINDING SITE FOR RESIDUE EDO B1871 source : BC5 56) chain A residue 634 type sequence R description BINDING SITE FOR RESIDUE EDO A1874 source : BC6 57) chain A residue 635 type sequence N description BINDING SITE FOR RESIDUE EDO A1874 source : BC6 58) chain A residue 693 type sequence Y description BINDING SITE FOR RESIDUE EDO A1874 source : BC6 59) chain A residue 442 type sequence V description BINDING SITE FOR RESIDUE EDO A1875 source : BC7 60) chain A residue 446 type sequence R description BINDING SITE FOR RESIDUE EDO A1875 source : BC7 61) chain A residue 117 type sequence Y description BINDING SITE FOR RESIDUE EDO A1876 source : BC9 62) chain A residue 118 type sequence A description BINDING SITE FOR RESIDUE EDO A1876 source : BC9 63) chain A residue 119 type sequence D description BINDING SITE FOR RESIDUE EDO A1876 source : BC9 64) chain A residue 129 type sequence K description BINDING SITE FOR RESIDUE EDO A1876 source : BC9 65) chain A residue 130 type sequence A description BINDING SITE FOR RESIDUE EDO A1876 source : BC9 66) chain A residue 157 type sequence H description BINDING SITE FOR RESIDUE EDO A1876 source : BC9 67) chain A residue 382 type sequence R description BINDING SITE FOR RESIDUE EDO A1877 source : CC2 68) chain A residue 840 type sequence I description BINDING SITE FOR RESIDUE EDO A1877 source : CC2 69) chain A residue 43 type sequence S description BINDING SITE FOR RESIDUE EDO A1878 source : CC4 70) chain A residue 44 type sequence Q description BINDING SITE FOR RESIDUE EDO A1878 source : CC4 71) chain A residue 46 type sequence G description BINDING SITE FOR RESIDUE EDO A1878 source : CC4 72) chain A residue 47 type sequence T description BINDING SITE FOR RESIDUE EDO A1878 source : CC4 73) chain A residue 48 type sequence E description BINDING SITE FOR RESIDUE EDO A1878 source : CC4 74) chain A residue 90 type sequence E description BINDING SITE FOR RESIDUE EDO A1878 source : CC4 75) chain A residue 178 type sequence N description BINDING SITE FOR RESIDUE EDO A1879 source : CC5 76) chain A residue 199 type sequence D description BINDING SITE FOR RESIDUE EDO A1879 source : CC5 77) chain A residue 424 type sequence C description BINDING SITE FOR RESIDUE EDO A1879 source : CC5 78) chain A residue 462 type sequence E description BINDING SITE FOR RESIDUE EDO A1879 source : CC5 79) chain A residue 470 type sequence W description BINDING SITE FOR RESIDUE EDO A1879 source : CC5 80) chain A residue 88 type sequence D description BINDING SITE FOR RESIDUE EDO A1880 source : CC9 81) chain A residue 157 type sequence H description BINDING SITE FOR RESIDUE EDO A1880 source : CC9 82) chain A residue 162 type sequence Q description BINDING SITE FOR RESIDUE EDO A1880 source : CC9 83) chain A residue 775 type sequence F description BINDING SITE FOR RESIDUE EDO A1881 source : DC1 84) chain A residue 777 type sequence R description BINDING SITE FOR RESIDUE EDO A1881 source : DC1 85) chain A residue 326 type sequence H description BINDING SITE FOR RESIDUE EDO A1882 source : DC2 86) chain A residue 327 type sequence R description BINDING SITE FOR RESIDUE EDO A1882 source : DC2 87) chain A residue 450 type sequence N description BINDING SITE FOR RESIDUE EDO A1882 source : DC2 88) chain A residue 451 type sequence H description BINDING SITE FOR RESIDUE EDO A1882 source : DC2 89) chain A residue 74 type sequence Y description BINDING SITE FOR RESIDUE EDO A1883 source : DC3 90) chain A residue 568 type sequence A description BINDING SITE FOR RESIDUE EDO A1883 source : DC3 91) chain A residue 571 type sequence A description BINDING SITE FOR RESIDUE EDO A1883 source : DC3 92) chain A residue 572 type sequence A description BINDING SITE FOR RESIDUE EDO A1883 source : DC3 93) chain A residue 573 type sequence P description BINDING SITE FOR RESIDUE EDO A1883 source : DC3 94) chain A residue 576 type sequence Y description BINDING SITE FOR RESIDUE EDO A1883 source : DC3 95) chain A residue 626 type sequence R description BINDING SITE FOR RESIDUE EDO A1884 source : DC5 96) chain A residue 671 type sequence Q description BINDING SITE FOR RESIDUE EDO A1884 source : DC5 97) chain A residue 674 type sequence R description BINDING SITE FOR RESIDUE EDO A1884 source : DC5 98) chain A residue 772 type sequence S description BINDING SITE FOR RESIDUE EDO A1884 source : DC5 99) chain A residue 773 type sequence V description BINDING SITE FOR RESIDUE EDO A1884 source : DC5 100) chain A residue 211 type sequence R description BINDING SITE FOR RESIDUE EDO A1885 source : DC6 101) chain A residue 212 type sequence P description BINDING SITE FOR RESIDUE EDO A1885 source : DC6 102) chain A residue 402 type sequence N description BINDING SITE FOR RESIDUE EDO A1885 source : DC6 103) chain A residue 603 type sequence D description BINDING SITE FOR RESIDUE EDO A1886 source : DC7 104) chain A residue 604 type sequence Y description BINDING SITE FOR RESIDUE EDO A1886 source : DC7 105) chain A residue 778 type sequence K description BINDING SITE FOR RESIDUE EDO A1886 source : DC7 106) chain A residue 779 type sequence T description BINDING SITE FOR RESIDUE EDO A1886 source : DC7 107) chain A residue 42 type sequence F description BINDING SITE FOR RESIDUE EDO A1887 source : DC9 108) chain A residue 43 type sequence S description BINDING SITE FOR RESIDUE EDO A1887 source : DC9 109) chain A residue 44 type sequence Q description BINDING SITE FOR RESIDUE EDO A1887 source : DC9 110) chain A residue 47 type sequence T description BINDING SITE FOR RESIDUE EDO A1887 source : DC9 111) chain A residue 49 type sequence K description BINDING SITE FOR RESIDUE EDO A1887 source : DC9 112) chain A residue 51 type sequence M description BINDING SITE FOR RESIDUE EDO A1887 source : DC9 113) chain A residue 63 type sequence L description BINDING SITE FOR RESIDUE EDO A1887 source : DC9 114) chain A residue 161 type sequence R description BINDING SITE FOR RESIDUE EDO A1888 source : EC3 115) chain A residue 162 type sequence Q description BINDING SITE FOR RESIDUE EDO A1888 source : EC3 116) chain A residue 165 type sequence P description BINDING SITE FOR RESIDUE EDO A1888 source : EC3 117) chain A residue 376 type sequence R description BINDING SITE FOR RESIDUE EDO A1889 source : EC6 118) chain A residue 661 type sequence Y description BINDING SITE FOR RESIDUE EDO A1889 source : EC6 119) chain A residue 662 type sequence Y description BINDING SITE FOR RESIDUE EDO A1889 source : EC6 120) chain A residue 542 type sequence F description BINDING SITE FOR RESIDUE EDO A1890 source : EC8 121) chain A residue 543 type sequence E description BINDING SITE FOR RESIDUE EDO A1890 source : EC8 122) chain A residue 603 type sequence D description BINDING SITE FOR RESIDUE EDO A1890 source : EC8 123) chain A residue 624 type sequence G description BINDING SITE FOR RESIDUE EDO A1890 source : EC8 124) chain A residue 119 type sequence D description BINDING SITE FOR RESIDUE EDO B1885 source : EC9 125) chain A residue 121 type sequence Y description BINDING SITE FOR RESIDUE EDO B1885 source : EC9 126) chain A residue 155 type sequence Y description BINDING SITE FOR RESIDUE EDO B1885 source : EC9 127) chain A residue 107 type sequence I description BINDING SITE FOR RESIDUE BR A1891 source : FC1 128) chain A residue 142 type sequence K description BINDING SITE FOR RESIDUE BR A1891 source : FC1 129) chain A residue 284 type sequence H description BINDING SITE FOR RESIDUE BR A1892 source : FC3 130) chain A residue 129 type sequence K description BINDING SITE FOR RESIDUE BR A1893 source : FC4 131) chain A residue 157 type sequence H description BINDING SITE FOR RESIDUE BR A1893 source : FC4 132) chain A residue 108 type sequence Q description BINDING SITE FOR RESIDUE CL A1895 source : FC9 133) chain A residue 627 type sequence H description BINDING SITE FOR RESIDUE CL A1896 source : GC1 134) chain A residue 684 type sequence I description BINDING SITE FOR RESIDUE CL A1896 source : GC1 135) chain A residue 685 type sequence Q description BINDING SITE FOR RESIDUE CL A1896 source : GC1 136) chain A residue 685 type sequence Q description BINDING SITE FOR RESIDUE CL A1897 source : GC2 137) chain A residue 688 type sequence D description BINDING SITE FOR RESIDUE CL A1897 source : GC2 138) chain A residue 337 type sequence N description BINDING SITE FOR RESIDUE CL A1901 source : GC6 139) chain A residue 786 type sequence P description BINDING SITE FOR RESIDUE CL A1898 source : GC7 140) chain A residue 787 type sequence T description BINDING SITE FOR RESIDUE CL A1898 source : GC7 141) chain A residue 861 type sequence E description BINDING SITE FOR RESIDUE CL A1898 source : GC7 142) chain A residue 300 type sequence N description BINDING SITE FOR RESIDUE BR A1899 source : GC8 143) chain A residue 390 type sequence N description BINDING SITE FOR RESIDUE BR A1899 source : GC8 144) chain A residue 476 type sequence F description BINDING SITE FOR RESIDUE CL A1900 source : HC3 145) chain A residue 477 type sequence T description BINDING SITE FOR RESIDUE CL A1900 source : HC3

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