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eF-site ID
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2ven-A |
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PDB Code
|
2ven |
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Chain
|
A |
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click to enlarge
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Title
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Structure-based enzyme engineering efforts with an inactive monomeric TIM variant: the importance of a single point mutation for generating an active site with suitable binding properties |
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Classification
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ISOMERASE |
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Compound
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GLYCOSOMAL TRIOSEPHOSPHATE ISOMERASE |
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Source
|
(TPIS_TRYBB) |
|
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Sequence
|
A: |
SKPQPIAAANWKSLSELIDLFNSTSINHDVQCVVASTFVH
LAMTKERLSHPKFVIAAQNAGNADALASLKDFGVNWIVLG
HSERRWYYGETNEIVADKVAAAVASGFMVIACIGETLQER
ESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPVWKVAT
PQQAQEAHALIRSWVSSKIGADVAGELRILYGGSVNGKNA
RTLYQQRDVNGFLAGLKPEFVDIIKATQ
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Description
|
|
Functional site
|
|
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1)
|
chain |
A |
| residue |
103 |
| type |
ACT_SITE |
| sequence |
G
|
| description |
Electrophile
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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2)
|
chain |
A |
| residue |
11 |
| type |
BINDING |
| sequence |
N
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
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3)
|
chain |
A |
| residue |
13 |
| type |
BINDING |
| sequence |
K
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI3
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|
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