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eF-site ID
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2vdp-B |
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PDB Code
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2vdp |
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Chain
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B |
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click to enlarge
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Title
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Integrin AlphaIIbBeta3 Headpiece Bound to Fibrinogen Gamma chain peptide,LGGAKQAGDV |
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Classification
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CELL ADHESION/IMMUNE SYSTEM |
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Compound
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INTEGRIN ALPHA-IIB |
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Source
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ORGANISM_COMMON: MOUSE; ORGANISM_SCIENTIFIC: MUS MUSCULUS; |
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Sequence
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B: |
GPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDL
KENLLKDNCAPESIEFPVSEARVLEDRPLSDKQVTQVSPQ
RIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKD
DLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMY
ISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEE
VKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLL
VFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTT
MDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIP
GTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEEL
SLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGC
PQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSH
RCNNGNGTFECGVCR
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Description
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(1) |
INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, FIBRINOGEN, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN
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Functional site
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1)
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chain |
B |
| residue |
220 |
| type |
CROSSLNK |
| sequence |
E
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| description |
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-424)
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| source |
Swiss-Prot : SWS_FT_FI1
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2)
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chain |
B |
| residue |
158 |
| type |
BINDING |
| sequence |
D
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| description |
in LIMBS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
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| source |
Swiss-Prot : SWS_FT_FI4
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3)
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chain |
B |
| residue |
215 |
| type |
BINDING |
| sequence |
N
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| description |
in LIMBS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
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| source |
Swiss-Prot : SWS_FT_FI4
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4)
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chain |
B |
| residue |
217 |
| type |
BINDING |
| sequence |
D
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| description |
in LIMBS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
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| source |
Swiss-Prot : SWS_FT_FI4
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5)
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chain |
B |
| residue |
219 |
| type |
BINDING |
| sequence |
P
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| description |
in LIMBS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
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| source |
Swiss-Prot : SWS_FT_FI4
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6)
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chain |
B |
| residue |
251 |
| type |
BINDING |
| sequence |
D
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| description |
in LIMBS binding site => ECO:0007744|PDB:4G1M
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| source |
Swiss-Prot : SWS_FT_FI5
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7)
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chain |
B |
| residue |
335 |
| type |
BINDING |
| sequence |
M
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| description |
in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3IJE
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| source |
Swiss-Prot : SWS_FT_FI6
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8)
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chain |
B |
| residue |
99 |
| type |
CARBOHYD |
| sequence |
N
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| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE
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| source |
Swiss-Prot : SWS_FT_FI7
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9)
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chain |
B |
| residue |
320 |
| type |
CARBOHYD |
| sequence |
N
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| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE
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| source |
Swiss-Prot : SWS_FT_FI8
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10)
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chain |
B |
| residue |
371 |
| type |
CARBOHYD |
| sequence |
N
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| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE
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| source |
Swiss-Prot : SWS_FT_FI8
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11)
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chain |
B |
| residue |
452 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:3IJE
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| source |
Swiss-Prot : SWS_FT_FI9
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12)
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chain |
B |
| residue |
126 |
| type |
BINDING |
| sequence |
D
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| description |
in ADMIDAS binding site => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU, ECO:0007744|PDB:3IJE
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| source |
Swiss-Prot : SWS_FT_FI3
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13)
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chain |
B |
| residue |
127 |
| type |
BINDING |
| sequence |
D
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| description |
in ADMIDAS binding site => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU, ECO:0007744|PDB:3IJE
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| source |
Swiss-Prot : SWS_FT_FI3
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14)
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chain |
B |
| residue |
123 |
| type |
BINDING |
| sequence |
S
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| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCU
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| source |
Swiss-Prot : SWS_FT_FI2
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