eF-site ID 2vd6-D PDB Code 2vd6 Chain D click to enlarge Title Human adenylosuccinate lyase in complex with its substrate N6-(1,2- Dicarboxyethyl)-AMP, and its products AMP and fumarate. Classification LYASE Compound ADENYLOSUCCINATE LYASE Source Homo sapiens (Human) (PUR8_HUMAN) Sequence D:  GDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWL WLAEAEQTLGLPITDEQIQEMKSNLENIDFKMAAEEEKRL RHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIIL RNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQ LTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGT QASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYT RKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFPY KRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDS ANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIR QELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVV KQEGGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRAS QQVQRFLEEEVYPLLKPYESVM Description Functional site 1) chain D residue 20 type sequence R description BINDING SITE FOR RESIDUE AMP A 1000 source : AC1 2) chain D residue 21 type sequence Y description BINDING SITE FOR RESIDUE AMP A 1000 source : AC1 3) chain D residue 299 type sequence M description BINDING SITE FOR RESIDUE AMP A 1000 source : AC1 4) chain D residue 303 type sequence R description BINDING SITE FOR RESIDUE AMP A 1000 source : AC1 5) chain D residue 295 type sequence K description BINDING SITE FOR RESIDUE FUM A 1001 source : AC2 6) chain D residue 297 type sequence N description BINDING SITE FOR RESIDUE CL A 2001 source : AC4 7) chain D residue 299 type sequence M description BINDING SITE FOR RESIDUE CL A 2001 source : AC4 8) chain D residue 159 type sequence H description BINDING SITE FOR RESIDUE AMP C 1000 source : BC2 9) chain D residue 158 type sequence T description BINDING SITE FOR RESIDUE FUM C 1001 source : BC3 10) chain D residue 159 type sequence H description BINDING SITE FOR RESIDUE FUM C 1001 source : BC3 11) chain D residue 85 type sequence R description BINDING SITE FOR RESIDUE 2SA D 1002 source : BC6 12) chain D residue 86 type sequence H description BINDING SITE FOR RESIDUE 2SA D 1002 source : BC6 13) chain D residue 87 type sequence D description BINDING SITE FOR RESIDUE 2SA D 1002 source : BC6 14) chain D residue 111 type sequence T description BINDING SITE FOR RESIDUE 2SA D 1002 source : BC6 15) chain D residue 112 type sequence S description BINDING SITE FOR RESIDUE 2SA D 1002 source : BC6 16) chain D residue 241 type sequence Q description BINDING SITE FOR RESIDUE 2SA D 1002 source : BC6 17) chain D residue 329 type sequence R description BINDING SITE FOR RESIDUE 2SA D 1002 source : BC6 18) chain D residue 334 type sequence S description BINDING SITE FOR RESIDUE 2SA D 1002 source : BC6 19) chain D residue 335 type sequence A description BINDING SITE FOR RESIDUE 2SA D 1002 source : BC6 20) chain D residue 338 type sequence R description BINDING SITE FOR RESIDUE 2SA D 1002 source : BC6 21) chain D residue 35 type sequence K description BINDING SITE FOR RESIDUE GOL D 1003 source : BC7 22) chain D residue 39 type sequence W description BINDING SITE FOR RESIDUE GOL D 1003 source : BC7 23) chain D residue 87 type sequence D description BINDING SITE FOR RESIDUE GOL D 1003 source : BC7 24) chain D residue 116 type sequence G description BINDING SITE FOR RESIDUE GOL D 1003 source : BC7 25) chain D residue 120 type sequence D description BINDING SITE FOR RESIDUE GOL D 1003 source : BC7 26) chain D residue 334 type sequence S description BINDING SITE FOR RESIDUE GOL D 1003 source : BC7 27) chain D residue 338 type sequence R description BINDING SITE FOR RESIDUE GOL D 1003 source : BC7 28) chain D residue 111 type sequence T description BINDING SITE FOR RESIDUE CL D 2002 source : BC9 29) chain D residue 114 type sequence Y description BINDING SITE FOR RESIDUE CL D 2002 source : BC9 30) chain D residue 196 type sequence R description BINDING SITE FOR RESIDUE CL D 2002 source : BC9 31) chain D residue 199 type sequence K description BINDING SITE FOR RESIDUE CL D 2002 source : BC9 32) chain D residue 200 type sequence G description BINDING SITE FOR RESIDUE CL D 2002 source : BC9 33) chain D residue 159 type ACT_SITE sequence H description Proton donor/acceptor => ECO:0000269|PubMed:22812634 source Swiss-Prot : SWS_FT_FI1 34) chain D residue 147 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI5 35) chain D residue 295 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI5 36) chain D residue 415 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0007744|PubMed:25114211 source Swiss-Prot : SWS_FT_FI6 37) chain D residue 20 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 38) chain D residue 303 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 39) chain D residue 85 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 40) chain D residue 111 type BINDING sequence T description in other chain source Swiss-Prot : SWS_FT_FI3 41) chain D residue 241 type BINDING sequence Q description in other chain source Swiss-Prot : SWS_FT_FI3 42) chain D residue 329 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 43) chain D residue 334 type BINDING sequence S description in other chain source Swiss-Prot : SWS_FT_FI3 44) chain D residue 338 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3

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