eF-site ID 2vd6-B PDB Code 2vd6 Chain B click to enlarge Title Human adenylosuccinate lyase in complex with its substrate N6-(1,2- Dicarboxyethyl)-AMP, and its products AMP and fumarate. Classification LYASE Compound ADENYLOSUCCINATE LYASE Source Homo sapiens (Human) (PUR8_HUMAN) Sequence B:  GDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWL WLAEAEQTLGLPITDEQIQEMKSNLENIDFKMAAEEEKRL RHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIIL RNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQ LTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGT QASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYT RKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFYK RNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSA NRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQ ELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVK QEGGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQ QVQRFLEEEVYPLLKPYESVM Description Functional site 1) chain B residue 159 type sequence H description BINDING SITE FOR RESIDUE AMP A 1000 source : AC1 2) chain B residue 158 type sequence T description BINDING SITE FOR RESIDUE FUM A 1001 source : AC2 3) chain B residue 159 type sequence H description BINDING SITE FOR RESIDUE FUM A 1001 source : AC2 4) chain B residue 85 type sequence R description BINDING SITE FOR RESIDUE 2SA B 1002 source : AC6 5) chain B residue 86 type sequence H description BINDING SITE FOR RESIDUE 2SA B 1002 source : AC6 6) chain B residue 87 type sequence D description BINDING SITE FOR RESIDUE 2SA B 1002 source : AC6 7) chain B residue 111 type sequence T description BINDING SITE FOR RESIDUE 2SA B 1002 source : AC6 8) chain B residue 112 type sequence S description BINDING SITE FOR RESIDUE 2SA B 1002 source : AC6 9) chain B residue 241 type sequence Q description BINDING SITE FOR RESIDUE 2SA B 1002 source : AC6 10) chain B residue 329 type sequence R description BINDING SITE FOR RESIDUE 2SA B 1002 source : AC6 11) chain B residue 334 type sequence S description BINDING SITE FOR RESIDUE 2SA B 1002 source : AC6 12) chain B residue 335 type sequence A description BINDING SITE FOR RESIDUE 2SA B 1002 source : AC6 13) chain B residue 338 type sequence R description BINDING SITE FOR RESIDUE 2SA B 1002 source : AC6 14) chain B residue 35 type sequence K description BINDING SITE FOR RESIDUE GOL B 1003 source : AC7 15) chain B residue 87 type sequence D description BINDING SITE FOR RESIDUE GOL B 1003 source : AC7 16) chain B residue 116 type sequence G description BINDING SITE FOR RESIDUE GOL B 1003 source : AC7 17) chain B residue 120 type sequence D description BINDING SITE FOR RESIDUE GOL B 1003 source : AC7 18) chain B residue 334 type sequence S description BINDING SITE FOR RESIDUE GOL B 1003 source : AC7 19) chain B residue 338 type sequence R description BINDING SITE FOR RESIDUE GOL B 1003 source : AC7 20) chain B residue 120 type sequence D description BINDING SITE FOR RESIDUE GOL B 1004 source : AC8 21) chain B residue 337 type sequence R description BINDING SITE FOR RESIDUE GOL B 1004 source : AC8 22) chain B residue 338 type sequence R description BINDING SITE FOR RESIDUE GOL B 1004 source : AC8 23) chain B residue 341 type sequence L description BINDING SITE FOR RESIDUE GOL B 1004 source : AC8 24) chain B residue 342 type sequence A description BINDING SITE FOR RESIDUE GOL B 1004 source : AC8 25) chain B residue 111 type sequence T description BINDING SITE FOR RESIDUE CL B 2002 source : BC1 26) chain B residue 114 type sequence Y description BINDING SITE FOR RESIDUE CL B 2002 source : BC1 27) chain B residue 196 type sequence R description BINDING SITE FOR RESIDUE CL B 2002 source : BC1 28) chain B residue 199 type sequence K description BINDING SITE FOR RESIDUE CL B 2002 source : BC1 29) chain B residue 200 type sequence G description BINDING SITE FOR RESIDUE CL B 2002 source : BC1 30) chain B residue 20 type sequence R description BINDING SITE FOR RESIDUE AMP C 1000 source : BC2 31) chain B residue 21 type sequence Y description BINDING SITE FOR RESIDUE AMP C 1000 source : BC2 32) chain B residue 299 type sequence M description BINDING SITE FOR RESIDUE AMP C 1000 source : BC2 33) chain B residue 303 type sequence R description BINDING SITE FOR RESIDUE AMP C 1000 source : BC2 34) chain B residue 295 type sequence K description BINDING SITE FOR RESIDUE FUM C 1001 source : BC3 35) chain B residue 297 type sequence N description BINDING SITE FOR RESIDUE FUM C 1001 source : BC3 36) chain B residue 159 type ACT_SITE sequence H description Proton donor/acceptor => ECO:0000269|PubMed:22812634 source Swiss-Prot : SWS_FT_FI1 37) chain B residue 147 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI5 38) chain B residue 295 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI5 39) chain B residue 415 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0007744|PubMed:25114211 source Swiss-Prot : SWS_FT_FI6 40) chain B residue 20 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 41) chain B residue 303 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 42) chain B residue 329 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 43) chain B residue 334 type BINDING sequence S description in other chain source Swiss-Prot : SWS_FT_FI3 44) chain B residue 338 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 45) chain B residue 85 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 46) chain B residue 111 type BINDING sequence T description in other chain source Swiss-Prot : SWS_FT_FI3 47) chain B residue 241 type BINDING sequence Q description in other chain source Swiss-Prot : SWS_FT_FI3

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