eF-site ID 2vd6-A PDB Code 2vd6 Chain A click to enlarge Title Human adenylosuccinate lyase in complex with its substrate N6-(1,2- Dicarboxyethyl)-AMP, and its products AMP and fumarate. Classification LYASE Compound ADENYLOSUCCINATE LYASE Source Homo sapiens (Human) (PUR8_HUMAN) Sequence A:  GDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWL WLAEAEQTLGLPITDEQIQEMKSNLENIDFKMAAEEEKRL RHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIIL RNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQ LTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGT QASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYT RKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEP YKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDD SANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRI RQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASV VKQEGGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRA SQQVQRFLEEEVYPLLKPYES Description Functional site 1) chain A residue 85 type sequence R description BINDING SITE FOR RESIDUE AMP A 1000 source : AC1 2) chain A residue 86 type sequence H description BINDING SITE FOR RESIDUE AMP A 1000 source : AC1 3) chain A residue 87 type sequence D description BINDING SITE FOR RESIDUE AMP A 1000 source : AC1 4) chain A residue 112 type sequence S description BINDING SITE FOR RESIDUE AMP A 1000 source : AC1 5) chain A residue 241 type sequence Q description BINDING SITE FOR RESIDUE AMP A 1000 source : AC1 6) chain A residue 329 type sequence R description BINDING SITE FOR RESIDUE AMP A 1000 source : AC1 7) chain A residue 331 type sequence L description BINDING SITE FOR RESIDUE AMP A 1000 source : AC1 8) chain A residue 334 type sequence S description BINDING SITE FOR RESIDUE AMP A 1000 source : AC1 9) chain A residue 335 type sequence A description BINDING SITE FOR RESIDUE AMP A 1000 source : AC1 10) chain A residue 338 type sequence R description BINDING SITE FOR RESIDUE AMP A 1000 source : AC1 11) chain A residue 86 type sequence H description BINDING SITE FOR RESIDUE FUM A 1001 source : AC2 12) chain A residue 89 type sequence M description BINDING SITE FOR RESIDUE FUM A 1001 source : AC2 13) chain A residue 111 type sequence T description BINDING SITE FOR RESIDUE FUM A 1001 source : AC2 14) chain A residue 112 type sequence S description BINDING SITE FOR RESIDUE FUM A 1001 source : AC2 15) chain A residue 241 type sequence Q description BINDING SITE FOR RESIDUE FUM A 1001 source : AC2 16) chain A residue 35 type sequence K description BINDING SITE FOR RESIDUE GOL A 1003 source : AC3 17) chain A residue 39 type sequence W description BINDING SITE FOR RESIDUE GOL A 1003 source : AC3 18) chain A residue 87 type sequence D description BINDING SITE FOR RESIDUE GOL A 1003 source : AC3 19) chain A residue 116 type sequence G description BINDING SITE FOR RESIDUE GOL A 1003 source : AC3 20) chain A residue 120 type sequence D description BINDING SITE FOR RESIDUE GOL A 1003 source : AC3 21) chain A residue 334 type sequence S description BINDING SITE FOR RESIDUE GOL A 1003 source : AC3 22) chain A residue 338 type sequence R description BINDING SITE FOR RESIDUE GOL A 1003 source : AC3 23) chain A residue 111 type sequence T description BINDING SITE FOR RESIDUE CL A 2002 source : AC5 24) chain A residue 114 type sequence Y description BINDING SITE FOR RESIDUE CL A 2002 source : AC5 25) chain A residue 196 type sequence R description BINDING SITE FOR RESIDUE CL A 2002 source : AC5 26) chain A residue 199 type sequence K description BINDING SITE FOR RESIDUE CL A 2002 source : AC5 27) chain A residue 200 type sequence G description BINDING SITE FOR RESIDUE CL A 2002 source : AC5 28) chain A residue 158 type sequence T description BINDING SITE FOR RESIDUE 2SA B 1002 source : AC6 29) chain A residue 159 type sequence H description BINDING SITE FOR RESIDUE 2SA B 1002 source : AC6 30) chain A residue 20 type sequence R description BINDING SITE FOR RESIDUE 2SA D 1002 source : BC6 31) chain A residue 21 type sequence Y description BINDING SITE FOR RESIDUE 2SA D 1002 source : BC6 32) chain A residue 295 type sequence K description BINDING SITE FOR RESIDUE 2SA D 1002 source : BC6 33) chain A residue 299 type sequence M description BINDING SITE FOR RESIDUE 2SA D 1002 source : BC6 34) chain A residue 303 type sequence R description BINDING SITE FOR RESIDUE 2SA D 1002 source : BC6 35) chain A residue 297 type sequence N description BINDING SITE FOR RESIDUE CL D 2001 source : BC8 36) chain A residue 299 type sequence M description BINDING SITE FOR RESIDUE CL D 2001 source : BC8 37) chain A residue 159 type ACT_SITE sequence H description Proton donor/acceptor => ECO:0000269|PubMed:22812634 source Swiss-Prot : SWS_FT_FI1 38) chain A residue 147 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI5 39) chain A residue 295 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI5 40) chain A residue 415 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0007744|PubMed:25114211 source Swiss-Prot : SWS_FT_FI6 41) chain A residue 20 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 42) chain A residue 303 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 43) chain A residue 85 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 44) chain A residue 111 type BINDING sequence T description in other chain source Swiss-Prot : SWS_FT_FI3 45) chain A residue 334 type BINDING sequence S description in other chain source Swiss-Prot : SWS_FT_FI3 46) chain A residue 338 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 47) chain A residue 241 type BINDING sequence Q description in other chain source Swiss-Prot : SWS_FT_FI3 48) chain A residue 329 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3

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