eF-site ID 2vcq-ABCD
PDB Code 2vcq
Chain A, B, C, D

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Title Complex structure of prostaglandin D2 synthase at 1.95A.
Classification ISOMERASE
Compound GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE
Source Homo sapiens (Human) (PTGD2_HUMAN)
Sequence A:  PNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPE
IKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNT
EMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLT
YNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLL
VFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL
B:  PNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPE
IKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNT
EMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLT
YNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLL
VFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL
C:  PNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPE
IKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNT
EMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLT
YNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLL
VFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL
D:  PNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPE
IKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNT
EMEQCHVDAIVDTLDDFMQDVKEQMFNELLTYNAPHLMQD
LDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDN
HPRLVTLRKKVQAIPAVANWIKRRPQTKL
Description


Functional site
1) chain A
residue 8
type
sequence Y
description BINDING SITE FOR RESIDUE GSH A1200
source : AC1
2) chain A
residue 14
type
sequence R
description BINDING SITE FOR RESIDUE GSH A1200
source : AC1
3) chain A
residue 39
type
sequence W
description BINDING SITE FOR RESIDUE GSH A1200
source : AC1
4) chain A
residue 43
type
sequence K
description BINDING SITE FOR RESIDUE GSH A1200
source : AC1
5) chain A
residue 50
type
sequence K
description BINDING SITE FOR RESIDUE GSH A1200
source : AC1
6) chain A
residue 51
type
sequence I
description BINDING SITE FOR RESIDUE GSH A1200
source : AC1
7) chain A
residue 63
type
sequence Q
description BINDING SITE FOR RESIDUE GSH A1200
source : AC1
8) chain A
residue 64
type
sequence S
description BINDING SITE FOR RESIDUE GSH A1200
source : AC1
9) chain B
residue 97
type
sequence D
description BINDING SITE FOR RESIDUE GSH A1200
source : AC1
10) chain A
residue 97
type
sequence D
description BINDING SITE FOR RESIDUE GSH B1200
source : AC2
11) chain B
residue 8
type
sequence Y
description BINDING SITE FOR RESIDUE GSH B1200
source : AC2
12) chain B
residue 14
type
sequence R
description BINDING SITE FOR RESIDUE GSH B1200
source : AC2
13) chain B
residue 39
type
sequence W
description BINDING SITE FOR RESIDUE GSH B1200
source : AC2
14) chain B
residue 43
type
sequence K
description BINDING SITE FOR RESIDUE GSH B1200
source : AC2
15) chain B
residue 50
type
sequence K
description BINDING SITE FOR RESIDUE GSH B1200
source : AC2
16) chain B
residue 51
type
sequence I
description BINDING SITE FOR RESIDUE GSH B1200
source : AC2
17) chain B
residue 63
type
sequence Q
description BINDING SITE FOR RESIDUE GSH B1200
source : AC2
18) chain B
residue 64
type
sequence S
description BINDING SITE FOR RESIDUE GSH B1200
source : AC2
19) chain C
residue 8
type
sequence Y
description BINDING SITE FOR RESIDUE GSH C1200
source : AC3
20) chain C
residue 14
type
sequence R
description BINDING SITE FOR RESIDUE GSH C1200
source : AC3
21) chain C
residue 39
type
sequence W
description BINDING SITE FOR RESIDUE GSH C1200
source : AC3
22) chain C
residue 43
type
sequence K
description BINDING SITE FOR RESIDUE GSH C1200
source : AC3
23) chain C
residue 50
type
sequence K
description BINDING SITE FOR RESIDUE GSH C1200
source : AC3
24) chain C
residue 51
type
sequence I
description BINDING SITE FOR RESIDUE GSH C1200
source : AC3
25) chain C
residue 52
type
sequence P
description BINDING SITE FOR RESIDUE GSH C1200
source : AC3
26) chain C
residue 63
type
sequence Q
description BINDING SITE FOR RESIDUE GSH C1200
source : AC3
27) chain C
residue 64
type
sequence S
description BINDING SITE FOR RESIDUE GSH C1200
source : AC3
28) chain D
residue 97
type
sequence D
description BINDING SITE FOR RESIDUE GSH C1200
source : AC3
29) chain C
residue 97
type
sequence D
description BINDING SITE FOR RESIDUE GSH D1200
source : AC4
30) chain D
residue 8
type
sequence Y
description BINDING SITE FOR RESIDUE GSH D1200
source : AC4
31) chain D
residue 14
type
sequence R
description BINDING SITE FOR RESIDUE GSH D1200
source : AC4
32) chain D
residue 39
type
sequence W
description BINDING SITE FOR RESIDUE GSH D1200
source : AC4
33) chain D
residue 43
type
sequence K
description BINDING SITE FOR RESIDUE GSH D1200
source : AC4
34) chain D
residue 50
type
sequence K
description BINDING SITE FOR RESIDUE GSH D1200
source : AC4
35) chain D
residue 51
type
sequence I
description BINDING SITE FOR RESIDUE GSH D1200
source : AC4
36) chain D
residue 52
type
sequence P
description BINDING SITE FOR RESIDUE GSH D1200
source : AC4
37) chain D
residue 63
type
sequence Q
description BINDING SITE FOR RESIDUE GSH D1200
source : AC4
38) chain D
residue 64
type
sequence S
description BINDING SITE FOR RESIDUE GSH D1200
source : AC4
39) chain A
residue 14
type
sequence R
description BINDING SITE FOR RESIDUE D25 A1201
source : AC5
40) chain A
residue 99
type
sequence M
description BINDING SITE FOR RESIDUE D25 A1201
source : AC5
41) chain A
residue 152
type
sequence Y
description BINDING SITE FOR RESIDUE D25 A1201
source : AC5
42) chain B
residue 11
type
sequence M
description BINDING SITE FOR RESIDUE D25 B1201
source : AC6
43) chain B
residue 13
type
sequence G
description BINDING SITE FOR RESIDUE D25 B1201
source : AC6
44) chain B
residue 14
type
sequence R
description BINDING SITE FOR RESIDUE D25 B1201
source : AC6
45) chain B
residue 99
type
sequence M
description BINDING SITE FOR RESIDUE D25 B1201
source : AC6
46) chain B
residue 104
type
sequence W
description BINDING SITE FOR RESIDUE D25 B1201
source : AC6
47) chain B
residue 152
type
sequence Y
description BINDING SITE FOR RESIDUE D25 B1201
source : AC6
48) chain C
residue 11
type
sequence M
description BINDING SITE FOR RESIDUE D25 C1201
source : AC7
49) chain C
residue 13
type
sequence G
description BINDING SITE FOR RESIDUE D25 C1201
source : AC7
50) chain C
residue 14
type
sequence R
description BINDING SITE FOR RESIDUE D25 C1201
source : AC7
51) chain C
residue 99
type
sequence M
description BINDING SITE FOR RESIDUE D25 C1201
source : AC7
52) chain C
residue 104
type
sequence W
description BINDING SITE FOR RESIDUE D25 C1201
source : AC7
53) chain C
residue 152
type
sequence Y
description BINDING SITE FOR RESIDUE D25 C1201
source : AC7
54) chain C
residue 199
type
sequence L
description BINDING SITE FOR RESIDUE D25 C1201
source : AC7
55) chain A
residue 8
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518
source Swiss-Prot : SWS_FT_FI1
56) chain B
residue 63
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518
source Swiss-Prot : SWS_FT_FI1
57) chain C
residue 8
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518
source Swiss-Prot : SWS_FT_FI1
58) chain C
residue 14
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518
source Swiss-Prot : SWS_FT_FI1
59) chain C
residue 39
type BINDING
sequence W
description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518
source Swiss-Prot : SWS_FT_FI1
60) chain C
residue 49
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518
source Swiss-Prot : SWS_FT_FI1
61) chain C
residue 63
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518
source Swiss-Prot : SWS_FT_FI1
62) chain D
residue 8
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518
source Swiss-Prot : SWS_FT_FI1
63) chain D
residue 14
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518
source Swiss-Prot : SWS_FT_FI1
64) chain D
residue 39
type BINDING
sequence W
description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518
source Swiss-Prot : SWS_FT_FI1
65) chain D
residue 49
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518
source Swiss-Prot : SWS_FT_FI1
66) chain A
residue 14
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518
source Swiss-Prot : SWS_FT_FI1
67) chain D
residue 63
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518
source Swiss-Prot : SWS_FT_FI1
68) chain A
residue 39
type BINDING
sequence W
description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518
source Swiss-Prot : SWS_FT_FI1
69) chain A
residue 49
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518
source Swiss-Prot : SWS_FT_FI1
70) chain A
residue 63
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518
source Swiss-Prot : SWS_FT_FI1
71) chain B
residue 8
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518
source Swiss-Prot : SWS_FT_FI1
72) chain B
residue 14
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518
source Swiss-Prot : SWS_FT_FI1
73) chain B
residue 39
type BINDING
sequence W
description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518
source Swiss-Prot : SWS_FT_FI1
74) chain B
residue 49
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518
source Swiss-Prot : SWS_FT_FI1

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