eF-site ID 2vcq-A PDB Code 2vcq Chain A click to enlarge Title Complex structure of prostaglandin D2 synthase at 1.95A. Classification ISOMERASE Compound GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE Source Homo sapiens (Human) (PTGD2_HUMAN) Sequence A:  PNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPE IKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNT EMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLT YNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLL VFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL Description Functional site 1) chain A residue 8 type sequence Y description BINDING SITE FOR RESIDUE GSH A1200 source : AC1 2) chain A residue 14 type sequence R description BINDING SITE FOR RESIDUE GSH A1200 source : AC1 3) chain A residue 39 type sequence W description BINDING SITE FOR RESIDUE GSH A1200 source : AC1 4) chain A residue 43 type sequence K description BINDING SITE FOR RESIDUE GSH A1200 source : AC1 5) chain A residue 50 type sequence K description BINDING SITE FOR RESIDUE GSH A1200 source : AC1 6) chain A residue 51 type sequence I description BINDING SITE FOR RESIDUE GSH A1200 source : AC1 7) chain A residue 63 type sequence Q description BINDING SITE FOR RESIDUE GSH A1200 source : AC1 8) chain A residue 64 type sequence S description BINDING SITE FOR RESIDUE GSH A1200 source : AC1 9) chain A residue 97 type sequence D description BINDING SITE FOR RESIDUE GSH B1200 source : AC2 10) chain A residue 14 type sequence R description BINDING SITE FOR RESIDUE D25 A1201 source : AC5 11) chain A residue 99 type sequence M description BINDING SITE FOR RESIDUE D25 A1201 source : AC5 12) chain A residue 152 type sequence Y description BINDING SITE FOR RESIDUE D25 A1201 source : AC5 13) chain A residue 8 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 14 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 39 type BINDING sequence W description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 49 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 63 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518 source Swiss-Prot : SWS_FT_FI1

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