eF-site ID 2v88-ABDF
PDB Code 2v88
Chain A, B, D, F

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Title Crystal structure of RAG2-PHD finger in complex with H3R2me2sK4me2 peptide
Classification PROTEIN BINDING
Compound VDJ RECOMBINATION-ACTIVATING PROTEIN 2
Source (Q5TEC6_HUMAN)
Sequence A:  SPEFGYWITCCPTCDVDINTWVPFYSTELNKPAMIYCSHG
DGHWVHAQCMDLEERTLIHLSEGSNKYYCNEHVQIARA
B:  SPEFGYWITCCPTCDVDINTWVPFYSTELNKPAMIYCSHG
DGHWVHAQCMDLEERTLIHLSEGSNKYYCNEHVQIARA
D:  AXTXQTAA
F:  AXTXQTAA
Description


Functional site

1) chain A
residue 419
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1488
source : AC1

2) chain A
residue 423
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1488
source : AC1

3) chain A
residue 455
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 1488
source : AC1

4) chain A
residue 458
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1488
source : AC1

5) chain A
residue 446
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1489
source : AC2

6) chain A
residue 452
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 1489
source : AC2

7) chain A
residue 478
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1489
source : AC2

8) chain A
residue 481
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 1489
source : AC2

9) chain B
residue 419
type
sequence C
description BINDING SITE FOR RESIDUE ZN B 1488
source : AC3

10) chain B
residue 423
type
sequence C
description BINDING SITE FOR RESIDUE ZN B 1488
source : AC3

11) chain B
residue 455
type
sequence H
description BINDING SITE FOR RESIDUE ZN B 1488
source : AC3

12) chain B
residue 458
type
sequence C
description BINDING SITE FOR RESIDUE ZN B 1488
source : AC3

13) chain B
residue 446
type
sequence C
description BINDING SITE FOR RESIDUE ZN B 1489
source : AC4

14) chain B
residue 452
type
sequence H
description BINDING SITE FOR RESIDUE ZN B 1489
source : AC4

15) chain B
residue 478
type
sequence C
description BINDING SITE FOR RESIDUE ZN B 1489
source : AC4

16) chain B
residue 481
type
sequence H
description BINDING SITE FOR RESIDUE ZN B 1489
source : AC4

17) chain D
residue 4
type MOD_RES
sequence X
description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI3

18) chain F
residue 4
type MOD_RES
sequence X
description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI3

19) chain D
residue 5
type MOD_RES
sequence Q
description 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594
source Swiss-Prot : SWS_FT_FI4

20) chain F
residue 5
type MOD_RES
sequence Q
description 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594
source Swiss-Prot : SWS_FT_FI4

21) chain D
residue 6
type MOD_RES
sequence T
description Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790
source Swiss-Prot : SWS_FT_FI5

22) chain F
residue 6
type MOD_RES
sequence T
description Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790
source Swiss-Prot : SWS_FT_FI5

23) chain D
residue 8
type MOD_RES
sequence A
description Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433
source Swiss-Prot : SWS_FT_FI6

24) chain F
residue 8
type MOD_RES
sequence A
description Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433
source Swiss-Prot : SWS_FT_FI6

25) chain D
residue 3
type MOD_RES
sequence T
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2

26) chain B
residue 423
type MOD_RES
sequence C
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2

27) chain B
residue 446
type MOD_RES
sequence C
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2

28) chain B
residue 452
type MOD_RES
sequence H
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2

29) chain B
residue 455
type MOD_RES
sequence H
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2

30) chain B
residue 458
type MOD_RES
sequence C
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2

31) chain B
residue 478
type MOD_RES
sequence C
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2

32) chain B
residue 481
type MOD_RES
sequence H
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2

33) chain F
residue 3
type MOD_RES
sequence T
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2

34) chain A
residue 446
type MOD_RES
sequence C
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2

35) chain A
residue 452
type MOD_RES
sequence H
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2

36) chain A
residue 455
type MOD_RES
sequence H
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2

37) chain A
residue 458
type MOD_RES
sequence C
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2

38) chain A
residue 478
type MOD_RES
sequence C
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2

39) chain A
residue 481
type MOD_RES
sequence H
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2

40) chain B
residue 419
type MOD_RES
sequence C
description Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
source Swiss-Prot : SWS_FT_FI2

41) chain D
residue 2
type MOD_RES
sequence X
description Citrulline; alternate => ECO:0000269|PubMed:16567635
source Swiss-Prot : SWS_FT_FI1

42) chain F
residue 2
type MOD_RES
sequence X
description Citrulline; alternate => ECO:0000269|PubMed:16567635
source Swiss-Prot : SWS_FT_FI1


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