eF-site ID 2v7a-B PDB Code 2v7a Chain B click to enlarge Title Crystal structure of the T315I Abl mutant in complex with the inhibitor PHA-739358 Classification TRANSFERASE Compound PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 Source (ABL1_HUMAN) Sequence B:  KWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTL KEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYI IIEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEY LEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTX TAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIA TYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMR ACWQWNPSDRPSFAEIHQAFETMFQESSIS Description Functional site 1) chain B residue 248 type sequence L description BINDING SITE FOR RESIDUE 627 B 1504 source : AC2 2) chain B residue 250 type sequence G description BINDING SITE FOR RESIDUE 627 B 1504 source : AC2 3) chain B residue 269 type sequence A description BINDING SITE FOR RESIDUE 627 B 1504 source : AC2 4) chain B residue 271 type sequence K description BINDING SITE FOR RESIDUE 627 B 1504 source : AC2 5) chain B residue 316 type sequence E description BINDING SITE FOR RESIDUE 627 B 1504 source : AC2 6) chain B residue 317 type sequence F description BINDING SITE FOR RESIDUE 627 B 1504 source : AC2 7) chain B residue 318 type sequence M description BINDING SITE FOR RESIDUE 627 B 1504 source : AC2 8) chain B residue 319 type sequence T description BINDING SITE FOR RESIDUE 627 B 1504 source : AC2 9) chain B residue 321 type sequence G description BINDING SITE FOR RESIDUE 627 B 1504 source : AC2 10) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE 627 B 1504 source : AC2 11) chain B residue 370 type sequence L description BINDING SITE FOR RESIDUE 627 B 1504 source : AC2 12) chain B residue 381 type sequence D description BINDING SITE FOR RESIDUE 627 B 1504 source : AC2 13) chain B residue 368 type sequence N description BINDING SITE FOR RESIDUE MG B 1505 source : AC4 14) chain B residue 381 type sequence D description BINDING SITE FOR RESIDUE MG B 1505 source : AC4 15) chain B residue 446 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P00520 source Swiss-Prot : SWS_FT_FI6 16) chain B residue 393 type MOD_RES sequence X description Phosphotyrosine; by autocatalysis and SRC-type Tyr-kinases => ECO:0000269|PubMed:16912036 source Swiss-Prot : SWS_FT_FI5 17) chain B residue 363 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 18) chain B residue 248 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI2 19) chain B residue 271 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 20) chain B residue 316 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 21) chain B residue 253 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 22) chain B residue 257 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 23) chain B residue 413 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4

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