|
eF-site ID
|
2v5q-B |
PDB Code
|
2v5q |
Chain
|
B |
|
click to enlarge
|
|
Title
|
CRYSTAL STRUCTURE OF WILD-TYPE PLK-1 KINASE DOMAIN IN COMPLEX WITH A SELECTIVE DARPIN |
Classification
|
TRANSFERASE |
Compound
|
SERINE/THREONINE-PROTEIN KINASE PLK1 |
Source
|
(2V5Q) |
|
Sequence
|
B: |
EIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEV
FAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG
FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLR
QIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLA
TKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIG
CIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVA
ASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITC
LTIPP
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
B |
residue |
176 |
type |
ACT_SITE |
sequence |
D
|
description |
Proton acceptor => ECO:0000269|PubMed:18615013
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
2)
|
chain |
B |
residue |
194 |
type |
BINDING |
sequence |
D
|
description |
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
3)
|
chain |
B |
residue |
59 |
type |
BINDING |
sequence |
L
|
description |
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
4)
|
chain |
B |
residue |
82 |
type |
BINDING |
sequence |
K
|
description |
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
5)
|
chain |
B |
residue |
131 |
type |
BINDING |
sequence |
E
|
description |
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
6)
|
chain |
B |
residue |
178 |
type |
BINDING |
sequence |
K
|
description |
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
7)
|
chain |
B |
residue |
103 |
type |
MOD_RES |
sequence |
S
|
description |
Phosphoserine => ECO:0007744|PubMed:18691976
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
8)
|
chain |
B |
residue |
137 |
type |
MOD_RES |
sequence |
S
|
description |
Phosphoserine => ECO:0000305|PubMed:12207013
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
9)
|
chain |
B |
residue |
210 |
type |
MOD_RES |
sequence |
T
|
description |
Phosphothreonine; by AURKA => ECO:0000269|PubMed:12207013, ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:18615013, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
10)
|
chain |
B |
residue |
214 |
type |
MOD_RES |
sequence |
T
|
description |
Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195
|
source |
Swiss-Prot : SWS_FT_FI6
|
|
11)
|
chain |
B |
residue |
269 |
type |
MOD_RES |
sequence |
S
|
description |
Phosphoserine; by autocatalysis => ECO:0000250
|
source |
Swiss-Prot : SWS_FT_FI7
|
|
|
|