eF-site ID 2v5q-ABCD PDB Code 2v5q Chain A, B, C, D click to enlarge Title CRYSTAL STRUCTURE OF WILD-TYPE PLK-1 KINASE DOMAIN IN COMPLEX WITH A SELECTIVE DARPIN Classification TRANSFERASE Compound SERINE/THREONINE-PROTEIN KINASE PLK1 Source (2V5Q) Sequence A:  EIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEV FAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLR QIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLA TKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIG CIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVA ASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITC LTIPP B:  EIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEV FAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLR QIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLA TKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIG CIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVA ASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITC LTIPP C:  SDLGKKLLEAARAGQDDEVRILIANGADVNAVDNTGLTPL HLAAVSGHLEIVEVLLKHGADVDAADVYGFTPLHLAAMTG HLEIVEVLLKYGADVNAFDMTGSTPLHLAADEGHLEIVEV LLKYGADVNA D:  DLGKKLLEAARAGQDDEVRILIANGADVNAVDNTGLTPLH LAAVSGHLEIVEVLLKHGADVDAADVYGFTPLHLAAMTGH LEIVEVLLKYGADVNAFDMTGSTPLHLAADEGHLEIVEVL LKYGADVNA Description Functional site 1) chain A residue 176 type ACT_SITE sequence D description Proton acceptor => ECO:0000269|PubMed:18615013 source Swiss-Prot : SWS_FT_FI1 2) chain B residue 176 type ACT_SITE sequence D description Proton acceptor => ECO:0000269|PubMed:18615013 source Swiss-Prot : SWS_FT_FI1 3) chain A residue 59 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI2 4) chain B residue 194 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 5) chain A residue 82 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 6) chain A residue 131 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 7) chain A residue 178 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 8) chain A residue 194 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 9) chain B residue 59 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI2 10) chain B residue 82 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 11) chain B residue 131 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 12) chain B residue 178 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 13) chain A residue 103 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18691976 source Swiss-Prot : SWS_FT_FI3 14) chain B residue 103 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18691976 source Swiss-Prot : SWS_FT_FI3 15) chain A residue 137 type MOD_RES sequence S description Phosphoserine => ECO:0000305|PubMed:12207013 source Swiss-Prot : SWS_FT_FI4 16) chain B residue 137 type MOD_RES sequence S description Phosphoserine => ECO:0000305|PubMed:12207013 source Swiss-Prot : SWS_FT_FI4 17) chain A residue 210 type MOD_RES sequence T description Phosphothreonine; by AURKA => ECO:0000269|PubMed:12207013, ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:18615013, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI5 18) chain B residue 210 type MOD_RES sequence T description Phosphothreonine; by AURKA => ECO:0000269|PubMed:12207013, ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:18615013, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI5 19) chain A residue 214 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI6 20) chain B residue 214 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI6 21) chain A residue 59-82 type prosite sequence LGKGGFAKCFEISDADTKEVFAGK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGGFAKCFeIsdadtkev..........FAGK source prosite : PS00107 22) chain A residue 172-184 type prosite sequence VIHRDLKLGNLFL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDLKlgNLFL source prosite : PS00108 23) chain A residue 269 type MOD_RES sequence S description Phosphoserine; by autocatalysis => ECO:0000250 source Swiss-Prot : SWS_FT_FI7 24) chain B residue 269 type MOD_RES sequence S description Phosphoserine; by autocatalysis => ECO:0000250 source Swiss-Prot : SWS_FT_FI7

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