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eF-site ID
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2v5q-A |
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PDB Code
|
2v5q |
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Chain
|
A |
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click to enlarge
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Title
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CRYSTAL STRUCTURE OF WILD-TYPE PLK-1 KINASE DOMAIN IN COMPLEX WITH A SELECTIVE DARPIN |
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Classification
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TRANSFERASE |
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Compound
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SERINE/THREONINE-PROTEIN KINASE PLK1 |
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Source
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(2V5Q) |
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Sequence
|
A: |
EIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEV
FAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG
FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLR
QIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLA
TKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIG
CIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVA
ASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITC
LTIPP
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Description
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Functional site
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1)
|
chain |
A |
| residue |
59-82 |
| type |
prosite |
| sequence |
LGKGGFAKCFEISDADTKEVFAGK
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| description |
PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGGFAKCFeIsdadtkev..........FAGK
|
| source |
prosite : PS00107
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|
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2)
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chain |
A |
| residue |
172-184 |
| type |
prosite |
| sequence |
VIHRDLKLGNLFL
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| description |
PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDLKlgNLFL
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| source |
prosite : PS00108
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3)
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chain |
A |
| residue |
59 |
| type |
BINDING |
| sequence |
L
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
|
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4)
|
chain |
A |
| residue |
82 |
| type |
BINDING |
| sequence |
K
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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5)
|
chain |
A |
| residue |
131 |
| type |
BINDING |
| sequence |
E
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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6)
|
chain |
A |
| residue |
178 |
| type |
BINDING |
| sequence |
K
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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7)
|
chain |
A |
| residue |
194 |
| type |
BINDING |
| sequence |
D
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
A |
| residue |
210 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine; by AURKA => ECO:0000269|PubMed:12207013, ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:18615013, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
|
| source |
Swiss-Prot : SWS_FT_FI5
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|
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9)
|
chain |
A |
| residue |
214 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195
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| source |
Swiss-Prot : SWS_FT_FI6
|
|
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10)
|
chain |
A |
| residue |
269 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine; by autocatalysis => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
11)
|
chain |
A |
| residue |
176 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Proton acceptor => ECO:0000269|PubMed:18615013
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
12)
|
chain |
A |
| residue |
103 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0007744|PubMed:18691976
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
13)
|
chain |
A |
| residue |
137 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000305|PubMed:12207013
|
| source |
Swiss-Prot : SWS_FT_FI4
|
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