eF-site ID 2v5l-AB PDB Code 2v5l Chain A, B click to enlarge Title Structures of the Open and Closed State of Trypanosomal Triosephosphate Isomerase: as Observed in a New Crystal Form: Implications for the Reaction Mechanism Classification OXIDOREDUCTASE Compound TRIOSEPHOSPHATE ISOMERASE Source null (TPIS_TRYBB) Sequence A:  SKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCVV ASTFVHLAMTKERLSHPKFVIAAQNAIAKSGAFTGEVSLP ILKDFGVNWIVLGHSERRAYYGETNEIVADKVAAAVASGF MVIACIGETLQERESGRTAVVVLTQIAAIAKKLKKADWAK VVIAYEPVWAIGTGKVATPQQAQEAHALIRSWVSSKIGAD VAGELRILYGGSVNGKNARTLYQQRDVNGFLVGGASLKPE FVDIIKATQ B:  SKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCVV ASTFVHLAMTKERLSHPKFVIAAQNAIAKSGAFTGEVSLP ILKDFGVNWIVLGHSERRAYYGETNEIVADKVAAAVASGF MVIACIGETLQERESGRTAVVVLTQIAAIAKKLKKADWAK VVIAYEPVWAIGTGKVATPQQAQEAHALIRSWVSSKIGAD VAGELRILYGGSVNGKNARTLYQQRDVNGFLVGGASLKPE FVDIIKATQ Description (1)  TRIOSEPHOSPHATE ISOMERASE (E.C.5.3.1.1) Functional site 1) chain A residue 213 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1251 source : AC1 2) chain A residue 234 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1251 source : AC1 3) chain A residue 235 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1251 source : AC1 4) chain B residue 535 type sequence G description BINDING SITE FOR RESIDUE SO4 B 1551 source : AC2 5) chain A residue 165-175 type prosite sequence AYEPVWAIGTG description TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG source prosite : PS00171 6) chain B residue 395 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 7) chain A residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 8) chain B residue 467 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 9) chain A residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 10) chain B residue 311 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 11) chain B residue 313 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 12) chain A residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 13) chain A residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

Display surface Download Links