eF-site ID 2v50-F
PDB Code 2v50
Chain F

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Title The Missing Part of the Bacterial MexAB-OprM System: Structural determination of the Multidrug Exporter MexB
Classification MEMBRANE PROTEIN
Compound MULTIDRUG RESISTANCE PROTEIN MEXB
Source Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (MEXB_PSEAE)
Sequence F:  MSKFFIDRPIFAWVIALVIMLAGGLSILSLPVNQYPAIAP
PAIAVQVSYPGASAETVQDTVVQVIEQQMNGIDNLRYISS
ESNSDGSMTITVTFEQGTDPDIAQVQVQNKLQLATPLLPQ
EVQRQGIRVTKAVKNFLMVVGVVSTDGSMTKEDLSNYIVS
NIQDPLSRTKGVGDFQVFGSQYSMRIWLDPAKLNSYQLTP
GDVSSAIQAQNVQISSGQLGGLPAVKGQQLNATIIGKTRL
QTAEQFENILLKVNPDGSQVRLKDVADVGLGGQDYSINAQ
FNGSPASGIAIKLATGANALDTAKAIRQTIANLEPFMPQG
MKVVYPYDTTPVVSASIHEVVKTLGEAILLVFLVMYLFLQ
NFRATLIPTIAVPVVLLGTFGVLAAFGFSINTLTMFGMVL
AIGLLVDDAIVVVENVERVMAEEGLSPREAARKSMGQIQG
ALVGIAMVLSAVFLPMAFFGGSTGVIYRQFSITIVSAMAL
SVIVALILTPALCATMLKPIEKGDHGEHKGGFFGWFNRMF
LSTTHGYERGVASILKHRAPYLLIYVVIVAGMIWMFTRIP
TAFLPDEDQGVLFAQVQTPPGSSAERTQVVVDSMREYLLE
KESSSVSSVFTVTGFNFAGRGQSSGMAFIMLKPWEERPGG
ENSVFELAKRAQMHFFSFKDAMVFAFAPPSVLELGNATGF
DLFLQDQAGVGHEVLLQARNKFLMLAAQNPALQRVRPNGM
SDEPQYKLEIDDEKASALGVSLADINSTVSIAWGSSYVND
FIDRGRVKRVYLQGRPDARMNPDDLSKWYVRNDKGEMVPF
NAFATGKWEYGSPKLERYNGVPAMEILGEPAPGLSSGDAM
AAVEEIVKQLPKGVGYSWTGLSYEERLSGSQAPALYALSL
LVVFLCLAALYESWSIPFSVMLVVPLGVIGALLATSMRGL
SNDVFFQVGLLTTIGLSAKNAILIVEFAKELHEQGKGIVE
AAIEACRMRLRPIVMTSLAFILGVVPLAISTGAGSGSQHA
IGTGVIGGMVTATVLAIFWVPLFYVAVSTL
Description


Functional site

1) chain F
residue 10-28
type TRANSMEM
sequence IFAWVIALVIMLAGGLSIL
description Helical
source Swiss-Prot : SWS_FT_FI2

2) chain F
residue 340-359
type TRANSMEM
sequence VVKTLGEAILLVFLVMYLFL
description Helical
source Swiss-Prot : SWS_FT_FI2

3) chain F
residue 366-385
type TRANSMEM
sequence LIPTIAVPVVLLGTFGVLAA
description Helical
source Swiss-Prot : SWS_FT_FI2

4) chain F
residue 392-413
type TRANSMEM
sequence TLTMFGMVLAIGLLVDDAIVVV
description Helical
source Swiss-Prot : SWS_FT_FI2

5) chain F
residue 442-460
type TRANSMEM
sequence LVGIAMVLSAVFLPMAFFG
description Helical
source Swiss-Prot : SWS_FT_FI2

6) chain F
residue 474-496
type TRANSMEM
sequence IVSAMALSVIVALILTPALCATM
description Helical
source Swiss-Prot : SWS_FT_FI2

7) chain F
residue 539-557
type TRANSMEM
sequence APYLLIYVVIVAGMIWMFT
description Helical
source Swiss-Prot : SWS_FT_FI2

8) chain F
residue 872-891
type TRANSMEM
sequence APALYALSLLVVFLCLAALY
description Helical
source Swiss-Prot : SWS_FT_FI2

9) chain F
residue 898-917
type TRANSMEM
sequence FSVMLVVPLGVIGALLATSM
description Helical
source Swiss-Prot : SWS_FT_FI2

10) chain F
residue 924-945
type TRANSMEM
sequence VFFQVGLLTTIGLSAKNAILIV
description Helical
source Swiss-Prot : SWS_FT_FI2

11) chain F
residue 973-991
type TRANSMEM
sequence IVMTSLAFILGVVPLAIST
description Helical
source Swiss-Prot : SWS_FT_FI2

12) chain F
residue 1005-1027
type TRANSMEM
sequence VIGGMVTATVLAIFWVPLFYVAV
description Helical
source Swiss-Prot : SWS_FT_FI2

13) chain F
residue 1-9
type TOPO_DOM
sequence MSKFFIDRP
description Cytoplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI1

14) chain F
residue 360-365
type TOPO_DOM
sequence QNFRAT
description Cytoplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI1

15) chain F
residue 414-441
type TOPO_DOM
sequence ENVERVMAEEGLSPREAARKSMGQIQGA
description Cytoplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI1

16) chain F
residue 497-538
type TOPO_DOM
sequence LKPIEKGDHGEHKGGFFGWFNRMFLSTTHGYERGVASILK
HR
description Cytoplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI1

17) chain F
residue 892-897
type TOPO_DOM
sequence ESWSIP
description Cytoplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI1

18) chain F
residue 946-972
type TOPO_DOM
sequence EFAKELHEQGKGIVEAAIEACRMRLRP
description Cytoplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI1

19) chain F
residue 29-339
type TOPO_DOM
sequence SLPVNQYPAIAPPAIAVQVSYPGASAETVQDTVVQVIEQQ
MNGIDNLRYISSESNSDGSMTITVTFEQGTDPDIAQVQVQ
NKLQLATPLLPQEVQRQGIRVTKAVKNFLMVVGVVSTDGS
MTKEDLSNYIVSNIQDPLSRTKGVGDFQVFGSQYSMRIWL
DPAKLNSYQLTPGDVSSAIQAQNVQISSGQLGGLPAVKGQ
QLNATIIGKTRLQTAEQFENILLKVNPDGSQVRLKDVADV
GLGGQDYSINAQFNGSPASGIAIKLATGANALDTAKAIRQ
TIANLEPFMPQGMKVVYPYDTTPVVSASIHE
description Periplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI3

20) chain F
residue 386-391
type TOPO_DOM
sequence FGFSIN
description Periplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI3

21) chain F
residue 461-473
type TOPO_DOM
sequence GSTGVIYRQFSIT
description Periplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI3

22) chain F
residue 558-871
type TOPO_DOM
sequence RIPTAFLPDEDQGVLFAQVQTPPGSSAERTQVVVDSMREY
LLEKESSSVSSVFTVTGFNFAGRGQSSGMAFIMLKPWEER
PGGENSVFELAKRAQMHFFSFKDAMVFAFAPPSVLELGNA
TGFDLFLQDQAGVGHEVLLQARNKFLMLAAQNPALQRVRP
NGMSDEPQYKLEIDDEKASALGVSLADINSTVSIAWGSSY
VNDFIDRGRVKRVYLQGRPDARMNPDDLSKWYVRNDKGEM
VPFNAFATGKWEYGSPKLERYNGVPAMEILGEPAPGLSSG
DAMAAVEEIVKQLPKGVGYSWTGLSYEERLSGSQ
description Periplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI3

23) chain F
residue 918-923
type TOPO_DOM
sequence RGLSND
description Periplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI3

24) chain F
residue 992-1004
type TOPO_DOM
sequence GAGSGSQHAIGTG
description Periplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI3


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