eF-site ID 2v50-E PDB Code 2v50 Chain E click to enlarge Title The Missing Part of the Bacterial MexAB-OprM System: Structural determination of the Multidrug Exporter MexB Classification MEMBRANE PROTEIN Compound MULTIDRUG RESISTANCE PROTEIN MEXB Source Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (MEXB_PSEAE) Sequence E:  MSKFFIDRPIFAWVIALVIMLAGGLSILSLPVNQYPAIAP PAIAVQVSYPGASAETVQDTVVQVIEQQMNGIDNLRYISS ESNSDGSMTITVTFEQGTDPDIAQVQVQNKLQLATPLLPQ EVQRQGIRVTKAVKNFLMVVGVVSTDGSMTKEDLSNYIVS NIQDPLSRTKGVGDFQVFGSQYSMRIWLDPAKLNSYQLTP GDVSSAIQAQNVQISSGQLGGLPAVKGQQLNATIIGKTRL QTAEQFENILLKVNPDGSQVRLKDVADVGLGGQDYSINAQ FNGSPASGIAIKLATGANALDTAKAIRQTIANLEPFMPQG MKVVYPYDTTPVVSASIHEVVKTLGEAILLVFLVMYLFLQ NFRATLIPTIAVPVVLLGTFGVLAAFGFSINTLTMFGMVL AIGLLVDDAIVVVENVERVMAEEGLSPREAARKSMGQIQG ALVGIAMVLSAVFLPMAFFGGSTGVIYRQFSITIVSAMAL SVIVALILTPALCATMLKPIEKGDHGEHKGGFFGWFNRMF LSTTHGYERGVASILKHRAPYLLIYVVIVAGMIWMFTRIP TAFLPDEDQGVLFAQVQTPPGSSAERTQVVVDSMREYLLE KESSSVSSVFTVTGFNFAGRGQSSGMAFIMLKPWEERPGG ENSVFELAKRAQMHFFSFKDAMVFAFAPDLFLQDQAGVGH EVLLQARNKFLMLAAQNPALQRVRPNGMSDEPQYKLEIDD EKASALGVSLADINSTVSIAWGSSYVNDFIDRGRVKRVYL QGRPDARMNPDDLSKWYVRNDKGEMVPFNAFATGKWEYGS PKLERYNGVPAMEILGEPAPGLSSGDAMAAVEEIVKQLPK GVGYSWTGLSYEERLSGSQAPALYALSLLVVFLCLAALYE SWSIPFSVMLVVPLGVIGALLATSMRGLSNDVFFQVGLLT TIGLSAKNAILIVEFAKELHEQGKGIVEAAIEACRMRLRP IVMTSLAFILGVVPLAIGSQHAIGTGVIGGMVTATVLAIF WVPLFYVAVSTL Description Functional site 1) chain E residue 386 type sequence F description BINDING SITE FOR RESIDUE LMT E 2031 source : AC5 2) chain E residue 454 type sequence L description BINDING SITE FOR RESIDUE LMT E 2031 source : AC5 3) chain E residue 457 type sequence A description BINDING SITE FOR RESIDUE LMT E 2031 source : AC5 4) chain E residue 458 type sequence F description BINDING SITE FOR RESIDUE LMT E 2031 source : AC5 5) chain E residue 468 type sequence R description BINDING SITE FOR RESIDUE LMT E 2031 source : AC5 6) chain E residue 472 type sequence I description BINDING SITE FOR RESIDUE LMT E 2031 source : AC5 7) chain E residue 454 type sequence L description BINDING SITE FOR RESIDUE LMT E 2032 source : AC6 8) chain E residue 458 type sequence F description BINDING SITE FOR RESIDUE LMT E 2032 source : AC6 9) chain E residue 870 type sequence S description BINDING SITE FOR RESIDUE LMT E 2032 source : AC6 10) chain E residue 871 type sequence Q description BINDING SITE FOR RESIDUE LMT E 2032 source : AC6 11) chain E residue 874 type sequence A description BINDING SITE FOR RESIDUE LMT E 2032 source : AC6 12) chain E residue 875 type sequence L description BINDING SITE FOR RESIDUE LMT E 2032 source : AC6 13) chain E residue 878 type sequence L description BINDING SITE FOR RESIDUE LMT E 2032 source : AC6 14) chain E residue 882 type sequence V description BINDING SITE FOR RESIDUE LMT E 2032 source : AC6 15) chain E residue 46 type sequence Q description BINDING SITE FOR RESIDUE LMT E 2033 source : AC7 16) chain E residue 47 type sequence V description BINDING SITE FOR RESIDUE LMT E 2033 source : AC7 17) chain E residue 48 type sequence S description BINDING SITE FOR RESIDUE LMT E 2033 source : AC7 18) chain E residue 89 type sequence T description BINDING SITE FOR RESIDUE LMT E 2033 source : AC7 19) chain E residue 125 type sequence Q description BINDING SITE FOR RESIDUE LMT E 2033 source : AC7 20) chain E residue 126 type sequence G description BINDING SITE FOR RESIDUE LMT E 2033 source : AC7 21) chain E residue 179 type sequence G description BINDING SITE FOR RESIDUE LMT E 2033 source : AC7 22) chain E residue 180 type sequence S description BINDING SITE FOR RESIDUE LMT E 2033 source : AC7 23) chain E residue 620 type sequence R description BINDING SITE FOR RESIDUE LMT E 2033 source : AC7 24) chain E residue 10-28 type TRANSMEM sequence IFAWVIALVIMLAGGLSIL description Helical source Swiss-Prot : SWS_FT_FI2 25) chain E residue 340-359 type TRANSMEM sequence VVKTLGEAILLVFLVMYLFL description Helical source Swiss-Prot : SWS_FT_FI2 26) chain E residue 366-385 type TRANSMEM sequence LIPTIAVPVVLLGTFGVLAA description Helical source Swiss-Prot : SWS_FT_FI2 27) chain E residue 392-413 type TRANSMEM sequence TLTMFGMVLAIGLLVDDAIVVV description Helical source Swiss-Prot : SWS_FT_FI2 28) chain E residue 442-460 type TRANSMEM sequence LVGIAMVLSAVFLPMAFFG description Helical source Swiss-Prot : SWS_FT_FI2 29) chain E residue 474-496 type TRANSMEM sequence IVSAMALSVIVALILTPALCATM description Helical source Swiss-Prot : SWS_FT_FI2 30) chain E residue 539-557 type TRANSMEM sequence APYLLIYVVIVAGMIWMFT description Helical source Swiss-Prot : SWS_FT_FI2 31) chain E residue 872-891 type TRANSMEM sequence APALYALSLLVVFLCLAALY description Helical source Swiss-Prot : SWS_FT_FI2 32) chain E residue 898-917 type TRANSMEM sequence FSVMLVVPLGVIGALLATSM description Helical source Swiss-Prot : SWS_FT_FI2 33) chain E residue 924-945 type TRANSMEM sequence VFFQVGLLTTIGLSAKNAILIV description Helical source Swiss-Prot : SWS_FT_FI2 34) chain E residue 1005-1027 type TRANSMEM sequence VIGGMVTATVLAIFWVPLFYVAV description Helical source Swiss-Prot : SWS_FT_FI2 35) chain E residue 1-9 type TOPO_DOM sequence MSKFFIDRP description Cytoplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI1 36) chain E residue 360-365 type TOPO_DOM sequence QNFRAT description Cytoplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI1 37) chain E residue 414-441 type TOPO_DOM sequence ENVERVMAEEGLSPREAARKSMGQIQGA description Cytoplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI1 38) chain E residue 497-538 type TOPO_DOM sequence LKPIEKGDHGEHKGGFFGWFNRMFLSTTHGYERGVASILK HR description Cytoplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI1 39) chain E residue 892-897 type TOPO_DOM sequence ESWSIP description Cytoplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI1 40) chain E residue 946-972 type TOPO_DOM sequence EFAKELHEQGKGIVEAAIEACRMRLRP description Cytoplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI1 41) chain E residue 29-339 type TOPO_DOM sequence SLPVNQYPAIAPPAIAVQVSYPGASAETVQDTVVQVIEQQ MNGIDNLRYISSESNSDGSMTITVTFEQGTDPDIAQVQVQ NKLQLATPLLPQEVQRQGIRVTKAVKNFLMVVGVVSTDGS MTKEDLSNYIVSNIQDPLSRTKGVGDFQVFGSQYSMRIWL DPAKLNSYQLTPGDVSSAIQAQNVQISSGQLGGLPAVKGQ QLNATIIGKTRLQTAEQFENILLKVNPDGSQVRLKDVADV GLGGQDYSINAQFNGSPASGIAIKLATGANALDTAKAIRQ TIANLEPFMPQGMKVVYPYDTTPVVSASIHE description Periplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI3 42) chain E residue 386-391 type TOPO_DOM sequence FGFSIN description Periplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI3 43) chain E residue 461-473 type TOPO_DOM sequence GSTGVIYRQFSIT description Periplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI3 44) chain E residue 558-871 type TOPO_DOM sequence RIPTAFLPDEDQGVLFAQVQTPPGSSAERTQVVVDSMREY LLEKESSSVSSVFTVTGFNFAGRGQSSGMAFIMLKPWEER PGGENSVFELAKRAQMHFFSFKDAMVFAFAPDLFLQDQAG VGHEVLLQARNKFLMLAAQNPALQRVRPNGMSDEPQYKLE IDDEKASALGVSLADINSTVSIAWGSSYVNDFIDRGRVKR VYLQGRPDARMNPDDLSKWYVRNDKGEMVPFNAFATGKWE YGSPKLERYNGVPAMEILGEPAPGLSSGDAMAAVEEIVKQ LPKGVGYSWTGLSYEERLSGSQ description Periplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI3 45) chain E residue 918-923 type TOPO_DOM sequence RGLSND description Periplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI3

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