eF-site ID 2v50-D PDB Code 2v50 Chain D click to enlarge Title The Missing Part of the Bacterial MexAB-OprM System: Structural determination of the Multidrug Exporter MexB Classification MEMBRANE PROTEIN Compound MULTIDRUG RESISTANCE PROTEIN MEXB Source Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (MEXB_PSEAE) Sequence D:  MSKFFIDRPIFAWVIALVIMLAGGLSILSLPVNQYPAIAP PAIAVQVSYPGASAETVQDTVVQVIEQQMNGIDNLRYISS ESNSDGSMTITVTFEQGTDPDIAQVQVQNKLQLATPLLPQ EVQRQGIRVTKAVKNFLMVVGVVSTDGSMTKEDLSNYIVS NIQDPLSRTKGVGDFQVFGSQYSMRIWLDPAKLNSYQLTP GDVSSAIQAQNVQISSGQLGGLPAVKGQQLNATIIGKTRL QTAEQFENILLKLKDVADVGLGGQDYSINAQFNGSPASGI AIKLATGANALDTAKAIRQTIANLEPFMPQGMKVVYPYDT TPVVSASIHEVVKTLGEAILLVFLVMYLFLQNFRATLIPT IAVPVVLLGTFGVLAAFGFSINTLTMFGMVLAIGLLVDDA IVVVENVERVMAEEGLSPREAARKSMGQIQGALVGIAMVL SAVFLPMAFFGGSTGVIYRQFSITIVSAMALSVIVALILT PALCATMLKPFFGWFNRMFLSTTHGYERGVASILKHRAPY LLIYVVIVAGMIWMFTRIPTAFLPDEDQGVLFAQVQTPPG SSAERTQVVVDSMREYLLEKESSSVSSVFTVTGFNFAGRG QSSGMAFIMLKPWEERPGGENSVFELAKRAQMHFFSFKDA MVFAFAPPNATGFDLFLQDQAGVGHEVLLQARNKFLMLAA QNPALQRVRPNGMSDEPQYKLEIDDEKASALGVSLADINS TVSIAWGSSYVNDFIDRGRVKRVYLQGRPDARMNPDDLSK WYVRNDKGEMVPFNAFATGKWEYGSPKLERYNGVPAMEIL GEPAPGLSSGDAMAAVEEIVKQLPKGVGYSWTGLSYEERL SGSQAPALYALSLLVVFLCLAALYESWSIPFSVMLVVPLG VIGALLATSMRGLSNDVFFQVGLLTTIGLSAKNAILIVEF AKELHEQGKGIVEAAIEACRMRLRPIVMTSLAFILGVVPL AISTGAGSGSQHAIGTGVIGGMVTATVLAIFWVPLFYV Description Functional site 1) chain D residue 13 type sequence W description BINDING SITE FOR RESIDUE LMT D 2026 source : AC4 2) chain D residue 17 type sequence L description BINDING SITE FOR RESIDUE LMT D 2026 source : AC4 3) chain D residue 363 type sequence R description BINDING SITE FOR RESIDUE LMT D 2026 source : AC4 4) chain D residue 495 type sequence T description BINDING SITE FOR RESIDUE LMT D 2026 source : AC4 5) chain D residue 498 type sequence K description BINDING SITE FOR RESIDUE LMT D 2026 source : AC4 6) chain D residue 25 type sequence L description BINDING SITE FOR RESIDUE LMT E 2032 source : AC6 7) chain D residue 28 type sequence L description BINDING SITE FOR RESIDUE LMT E 2032 source : AC6 8) chain D residue 1-9 type TOPO_DOM sequence MSKFFIDRP description Cytoplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI1 9) chain D residue 360-365 type TOPO_DOM sequence QNFRAT description Cytoplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI1 10) chain D residue 414-441 type TOPO_DOM sequence ENVERVMAEEGLSPREAARKSMGQIQGA description Cytoplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI1 11) chain D residue 497-538 type TOPO_DOM sequence LKPFFGWFNRMFLSTTHGYERGVASILKHR description Cytoplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI1 12) chain D residue 892-897 type TOPO_DOM sequence ESWSIP description Cytoplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI1 13) chain D residue 946-972 type TOPO_DOM sequence EFAKELHEQGKGIVEAAIEACRMRLRP description Cytoplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI1 14) chain D residue 29-339 type TOPO_DOM sequence SLPVNQYPAIAPPAIAVQVSYPGASAETVQDTVVQVIEQQ MNGIDNLRYISSESNSDGSMTITVTFEQGTDPDIAQVQVQ NKLQLATPLLPQEVQRQGIRVTKAVKNFLMVVGVVSTDGS MTKEDLSNYIVSNIQDPLSRTKGVGDFQVFGSQYSMRIWL DPAKLNSYQLTPGDVSSAIQAQNVQISSGQLGGLPAVKGQ QLNATIIGKTRLQTAEQFENILLKLKDVADVGLGGQDYSI NAQFNGSPASGIAIKLATGANALDTAKAIRQTIANLEPFM PQGMKVVYPYDTTPVVSASIHE description Periplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI3 15) chain D residue 386-391 type TOPO_DOM sequence FGFSIN description Periplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI3 16) chain D residue 461-473 type TOPO_DOM sequence GSTGVIYRQFSIT description Periplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI3 17) chain D residue 558-871 type TOPO_DOM sequence RIPTAFLPDEDQGVLFAQVQTPPGSSAERTQVVVDSMREY LLEKESSSVSSVFTVTGFNFAGRGQSSGMAFIMLKPWEER PGGENSVFELAKRAQMHFFSFKDAMVFAFAPPNATGFDLF LQDQAGVGHEVLLQARNKFLMLAAQNPALQRVRPNGMSDE PQYKLEIDDEKASALGVSLADINSTVSIAWGSSYVNDFID RGRVKRVYLQGRPDARMNPDDLSKWYVRNDKGEMVPFNAF ATGKWEYGSPKLERYNGVPAMEILGEPAPGLSSGDAMAAV EEIVKQLPKGVGYSWTGLSYEERLSGSQ description Periplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI3 18) chain D residue 918-923 type TOPO_DOM sequence RGLSND description Periplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI3 19) chain D residue 992-1004 type TOPO_DOM sequence GAGSGSQHAIGTG description Periplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI3 20) chain D residue 10-28 type TRANSMEM sequence IFAWVIALVIMLAGGLSIL description Helical source Swiss-Prot : SWS_FT_FI2 21) chain D residue 340-359 type TRANSMEM sequence VVKTLGEAILLVFLVMYLFL description Helical source Swiss-Prot : SWS_FT_FI2 22) chain D residue 366-385 type TRANSMEM sequence LIPTIAVPVVLLGTFGVLAA description Helical source Swiss-Prot : SWS_FT_FI2 23) chain D residue 392-413 type TRANSMEM sequence TLTMFGMVLAIGLLVDDAIVVV description Helical source Swiss-Prot : SWS_FT_FI2 24) chain D residue 442-460 type TRANSMEM sequence LVGIAMVLSAVFLPMAFFG description Helical source Swiss-Prot : SWS_FT_FI2 25) chain D residue 474-496 type TRANSMEM sequence IVSAMALSVIVALILTPALCATM description Helical source Swiss-Prot : SWS_FT_FI2 26) chain D residue 539-557 type TRANSMEM sequence APYLLIYVVIVAGMIWMFT description Helical source Swiss-Prot : SWS_FT_FI2 27) chain D residue 872-891 type TRANSMEM sequence APALYALSLLVVFLCLAALY description Helical source Swiss-Prot : SWS_FT_FI2 28) chain D residue 898-917 type TRANSMEM sequence FSVMLVVPLGVIGALLATSM description Helical source Swiss-Prot : SWS_FT_FI2 29) chain D residue 924-945 type TRANSMEM sequence VFFQVGLLTTIGLSAKNAILIV description Helical source Swiss-Prot : SWS_FT_FI2 30) chain D residue 973-991 type TRANSMEM sequence IVMTSLAFILGVVPLAIST description Helical source Swiss-Prot : SWS_FT_FI2

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