eF-site ID 2v50-A
PDB Code 2v50
Chain A

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Title The Missing Part of the Bacterial MexAB-OprM System: Structural determination of the Multidrug Exporter MexB
Classification MEMBRANE PROTEIN
Compound MULTIDRUG RESISTANCE PROTEIN MEXB
Source Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (MEXB_PSEAE)
Sequence A:  FFIDRPIFAWVIALVIMLAGGLSILSLPVNQYPAIAPPAI
AVQVSYPGASAETVQDTVVQVIEQQMNGIDNLRYISSESN
SDGSMTITVTFEQGTDPDIAQVQVQNKLQLATPLLPQEVQ
RQGIRVTKAVKNFLMVVGVVSTDGSMTKEDLSNYIVSNIQ
DPLSRTKGVGDFQVFGSQYSMRIWLDPAKLNSYQLTPGDV
SSAIQAQNVQISSGQLGGLPAVKGQQLNATIIGKTRLQTA
EQFENILLKVNPDGSQVRLKDVADVGLGGQDYSINAQFNG
SPASGIAIKLATGANALDTAKAIRQTIANLEPFMPQGMKV
VYPYDTTPVVSASIHEVVKTLGEAILLVFLVMYLFLQNFR
ATLIPTIAVPVVLLGTFGVLAAFGFSINTLTMFGMVLAIG
LLVDDAIVVVENVERVMAEEGLSPREAARKSMGQIQGALV
GIAMVLSAVFLPMAFFGGSTGVIYRQFSITIVSAMALSVI
VALILTPALCATMLKPFFGWFNRMFLSTTHGYERGVASIL
KHRAPYLLIYVVIVAGMIWMFTRIPTAFLPDEDQGVLFAQ
VQTPPGSSAERTQVVVDSMREYLLEKESSSVSSVFTVTGF
NFAGRGQSSGMAFIMLKPWEERPGGENSVFELAKRAQMHF
FSFKDAMVFAFAPPSVLTGFDLFLQDQAGVGHEVLLQARN
KFLMLAAQNPALQRVRPNGMSDEPQYKLEIDDEKASALGV
SLADINSTVSIAWGSSYVNDFIDRGRVKRVYLQGRPDARM
NPDDLSKWYVRNDKGEMVPFNAFATGKWEYGSPKLERYNG
VPAMEILGEPAPGLSSGDAMAAVEEIVKQLPKGVGYSWTG
LSYEERLSGSQAPALYALSLLVVFLCLAALYESWSIPFSV
MLVVPLGVIGALLATSMRGLSNDVFFQVGLLTTIGLSAKN
AILIVEFAKELHEQGKGIVEAAIEACRMRLRPIVMTSLAF
ILGVVPLAISTGAGSGSQHAIGTGVIGGMVTATVLAIFWV
PLFYV
Description


Functional site

1) chain A
residue 13
type
sequence W
description BINDING SITE FOR RESIDUE LMT A 2026
source : AC1

2) chain A
residue 17
type
sequence L
description BINDING SITE FOR RESIDUE LMT A 2026
source : AC1

3) chain A
residue 363
type
sequence R
description BINDING SITE FOR RESIDUE LMT A 2026
source : AC1

4) chain A
residue 495
type
sequence T
description BINDING SITE FOR RESIDUE LMT A 2026
source : AC1

5) chain A
residue 498
type
sequence K
description BINDING SITE FOR RESIDUE LMT A 2026
source : AC1

6) chain A
residue 360-365
type TOPO_DOM
sequence QNFRAT
description Cytoplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI1

7) chain A
residue 414-441
type TOPO_DOM
sequence ENVERVMAEEGLSPREAARKSMGQIQGA
description Cytoplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI1

8) chain A
residue 497-538
type TOPO_DOM
sequence LKPFFGWFNRMFLSTTHGYERGVASILKHR
description Cytoplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI1

9) chain A
residue 892-897
type TOPO_DOM
sequence ESWSIP
description Cytoplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI1

10) chain A
residue 946-972
type TOPO_DOM
sequence EFAKELHEQGKGIVEAAIEACRMRLRP
description Cytoplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI1

11) chain A
residue 10-28
type TRANSMEM
sequence IFAWVIALVIMLAGGLSIL
description Helical
source Swiss-Prot : SWS_FT_FI2

12) chain A
residue 924-945
type TRANSMEM
sequence VFFQVGLLTTIGLSAKNAILIV
description Helical
source Swiss-Prot : SWS_FT_FI2

13) chain A
residue 973-991
type TRANSMEM
sequence IVMTSLAFILGVVPLAIST
description Helical
source Swiss-Prot : SWS_FT_FI2

14) chain A
residue 340-359
type TRANSMEM
sequence VVKTLGEAILLVFLVMYLFL
description Helical
source Swiss-Prot : SWS_FT_FI2

15) chain A
residue 366-385
type TRANSMEM
sequence LIPTIAVPVVLLGTFGVLAA
description Helical
source Swiss-Prot : SWS_FT_FI2

16) chain A
residue 392-413
type TRANSMEM
sequence TLTMFGMVLAIGLLVDDAIVVV
description Helical
source Swiss-Prot : SWS_FT_FI2

17) chain A
residue 442-460
type TRANSMEM
sequence LVGIAMVLSAVFLPMAFFG
description Helical
source Swiss-Prot : SWS_FT_FI2

18) chain A
residue 474-496
type TRANSMEM
sequence IVSAMALSVIVALILTPALCATM
description Helical
source Swiss-Prot : SWS_FT_FI2

19) chain A
residue 539-557
type TRANSMEM
sequence APYLLIYVVIVAGMIWMFT
description Helical
source Swiss-Prot : SWS_FT_FI2

20) chain A
residue 872-891
type TRANSMEM
sequence APALYALSLLVVFLCLAALY
description Helical
source Swiss-Prot : SWS_FT_FI2

21) chain A
residue 898-917
type TRANSMEM
sequence FSVMLVVPLGVIGALLATSM
description Helical
source Swiss-Prot : SWS_FT_FI2

22) chain A
residue 29-339
type TOPO_DOM
sequence SLPVNQYPAIAPPAIAVQVSYPGASAETVQDTVVQVIEQQ
MNGIDNLRYISSESNSDGSMTITVTFEQGTDPDIAQVQVQ
NKLQLATPLLPQEVQRQGIRVTKAVKNFLMVVGVVSTDGS
MTKEDLSNYIVSNIQDPLSRTKGVGDFQVFGSQYSMRIWL
DPAKLNSYQLTPGDVSSAIQAQNVQISSGQLGGLPAVKGQ
QLNATIIGKTRLQTAEQFENILLKVNPDGSQVRLKDVADV
GLGGQDYSINAQFNGSPASGIAIKLATGANALDTAKAIRQ
TIANLEPFMPQGMKVVYPYDTTPVVSASIHE
description Periplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI3

23) chain A
residue 386-391
type TOPO_DOM
sequence FGFSIN
description Periplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI3

24) chain A
residue 461-473
type TOPO_DOM
sequence GSTGVIYRQFSIT
description Periplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI3

25) chain A
residue 558-871
type TOPO_DOM
sequence RIPTAFLPDEDQGVLFAQVQTPPGSSAERTQVVVDSMREY
LLEKESSSVSSVFTVTGFNFAGRGQSSGMAFIMLKPWEER
PGGENSVFELAKRAQMHFFSFKDAMVFAFAPPSVLTGFDL
FLQDQAGVGHEVLLQARNKFLMLAAQNPALQRVRPNGMSD
EPQYKLEIDDEKASALGVSLADINSTVSIAWGSSYVNDFI
DRGRVKRVYLQGRPDARMNPDDLSKWYVRNDKGEMVPFNA
FATGKWEYGSPKLERYNGVPAMEILGEPAPGLSSGDAMAA
VEEIVKQLPKGVGYSWTGLSYEERLSGSQ
description Periplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI3

26) chain A
residue 918-923
type TOPO_DOM
sequence RGLSND
description Periplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI3

27) chain A
residue 992-1004
type TOPO_DOM
sequence GAGSGSQHAIGTG
description Periplasmic => ECO:0000269|PubMed:10187844
source Swiss-Prot : SWS_FT_FI3


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