eF-site ID 2v50-A PDB Code 2v50 Chain A click to enlarge Title The Missing Part of the Bacterial MexAB-OprM System: Structural determination of the Multidrug Exporter MexB Classification MEMBRANE PROTEIN Compound MULTIDRUG RESISTANCE PROTEIN MEXB Source Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (MEXB_PSEAE) Sequence A:  FFIDRPIFAWVIALVIMLAGGLSILSLPVNQYPAIAPPAI AVQVSYPGASAETVQDTVVQVIEQQMNGIDNLRYISSESN SDGSMTITVTFEQGTDPDIAQVQVQNKLQLATPLLPQEVQ RQGIRVTKAVKNFLMVVGVVSTDGSMTKEDLSNYIVSNIQ DPLSRTKGVGDFQVFGSQYSMRIWLDPAKLNSYQLTPGDV SSAIQAQNVQISSGQLGGLPAVKGQQLNATIIGKTRLQTA EQFENILLKVNPDGSQVRLKDVADVGLGGQDYSINAQFNG SPASGIAIKLATGANALDTAKAIRQTIANLEPFMPQGMKV VYPYDTTPVVSASIHEVVKTLGEAILLVFLVMYLFLQNFR ATLIPTIAVPVVLLGTFGVLAAFGFSINTLTMFGMVLAIG LLVDDAIVVVENVERVMAEEGLSPREAARKSMGQIQGALV GIAMVLSAVFLPMAFFGGSTGVIYRQFSITIVSAMALSVI VALILTPALCATMLKPFFGWFNRMFLSTTHGYERGVASIL KHRAPYLLIYVVIVAGMIWMFTRIPTAFLPDEDQGVLFAQ VQTPPGSSAERTQVVVDSMREYLLEKESSSVSSVFTVTGF NFAGRGQSSGMAFIMLKPWEERPGGENSVFELAKRAQMHF FSFKDAMVFAFAPPSVLTGFDLFLQDQAGVGHEVLLQARN KFLMLAAQNPALQRVRPNGMSDEPQYKLEIDDEKASALGV SLADINSTVSIAWGSSYVNDFIDRGRVKRVYLQGRPDARM NPDDLSKWYVRNDKGEMVPFNAFATGKWEYGSPKLERYNG VPAMEILGEPAPGLSSGDAMAAVEEIVKQLPKGVGYSWTG LSYEERLSGSQAPALYALSLLVVFLCLAALYESWSIPFSV MLVVPLGVIGALLATSMRGLSNDVFFQVGLLTTIGLSAKN AILIVEFAKELHEQGKGIVEAAIEACRMRLRPIVMTSLAF ILGVVPLAISTGAGSGSQHAIGTGVIGGMVTATVLAIFWV PLFYV Description Functional site 1) chain A residue 13 type sequence W description BINDING SITE FOR RESIDUE LMT A 2026 source : AC1 2) chain A residue 17 type sequence L description BINDING SITE FOR RESIDUE LMT A 2026 source : AC1 3) chain A residue 363 type sequence R description BINDING SITE FOR RESIDUE LMT A 2026 source : AC1 4) chain A residue 495 type sequence T description BINDING SITE FOR RESIDUE LMT A 2026 source : AC1 5) chain A residue 498 type sequence K description BINDING SITE FOR RESIDUE LMT A 2026 source : AC1 6) chain A residue 360-365 type TOPO_DOM sequence QNFRAT description Cytoplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI1 7) chain A residue 414-441 type TOPO_DOM sequence ENVERVMAEEGLSPREAARKSMGQIQGA description Cytoplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI1 8) chain A residue 497-538 type TOPO_DOM sequence LKPFFGWFNRMFLSTTHGYERGVASILKHR description Cytoplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI1 9) chain A residue 892-897 type TOPO_DOM sequence ESWSIP description Cytoplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI1 10) chain A residue 946-972 type TOPO_DOM sequence EFAKELHEQGKGIVEAAIEACRMRLRP description Cytoplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI1 11) chain A residue 10-28 type TRANSMEM sequence IFAWVIALVIMLAGGLSIL description Helical source Swiss-Prot : SWS_FT_FI2 12) chain A residue 924-945 type TRANSMEM sequence VFFQVGLLTTIGLSAKNAILIV description Helical source Swiss-Prot : SWS_FT_FI2 13) chain A residue 973-991 type TRANSMEM sequence IVMTSLAFILGVVPLAIST description Helical source Swiss-Prot : SWS_FT_FI2 14) chain A residue 340-359 type TRANSMEM sequence VVKTLGEAILLVFLVMYLFL description Helical source Swiss-Prot : SWS_FT_FI2 15) chain A residue 366-385 type TRANSMEM sequence LIPTIAVPVVLLGTFGVLAA description Helical source Swiss-Prot : SWS_FT_FI2 16) chain A residue 392-413 type TRANSMEM sequence TLTMFGMVLAIGLLVDDAIVVV description Helical source Swiss-Prot : SWS_FT_FI2 17) chain A residue 442-460 type TRANSMEM sequence LVGIAMVLSAVFLPMAFFG description Helical source Swiss-Prot : SWS_FT_FI2 18) chain A residue 474-496 type TRANSMEM sequence IVSAMALSVIVALILTPALCATM description Helical source Swiss-Prot : SWS_FT_FI2 19) chain A residue 539-557 type TRANSMEM sequence APYLLIYVVIVAGMIWMFT description Helical source Swiss-Prot : SWS_FT_FI2 20) chain A residue 872-891 type TRANSMEM sequence APALYALSLLVVFLCLAALY description Helical source Swiss-Prot : SWS_FT_FI2 21) chain A residue 898-917 type TRANSMEM sequence FSVMLVVPLGVIGALLATSM description Helical source Swiss-Prot : SWS_FT_FI2 22) chain A residue 29-339 type TOPO_DOM sequence SLPVNQYPAIAPPAIAVQVSYPGASAETVQDTVVQVIEQQ MNGIDNLRYISSESNSDGSMTITVTFEQGTDPDIAQVQVQ NKLQLATPLLPQEVQRQGIRVTKAVKNFLMVVGVVSTDGS MTKEDLSNYIVSNIQDPLSRTKGVGDFQVFGSQYSMRIWL DPAKLNSYQLTPGDVSSAIQAQNVQISSGQLGGLPAVKGQ QLNATIIGKTRLQTAEQFENILLKVNPDGSQVRLKDVADV GLGGQDYSINAQFNGSPASGIAIKLATGANALDTAKAIRQ TIANLEPFMPQGMKVVYPYDTTPVVSASIHE description Periplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI3 23) chain A residue 386-391 type TOPO_DOM sequence FGFSIN description Periplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI3 24) chain A residue 461-473 type TOPO_DOM sequence GSTGVIYRQFSIT description Periplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI3 25) chain A residue 558-871 type TOPO_DOM sequence RIPTAFLPDEDQGVLFAQVQTPPGSSAERTQVVVDSMREY LLEKESSSVSSVFTVTGFNFAGRGQSSGMAFIMLKPWEER PGGENSVFELAKRAQMHFFSFKDAMVFAFAPPSVLTGFDL FLQDQAGVGHEVLLQARNKFLMLAAQNPALQRVRPNGMSD EPQYKLEIDDEKASALGVSLADINSTVSIAWGSSYVNDFI DRGRVKRVYLQGRPDARMNPDDLSKWYVRNDKGEMVPFNA FATGKWEYGSPKLERYNGVPAMEILGEPAPGLSSGDAMAA VEEIVKQLPKGVGYSWTGLSYEERLSGSQ description Periplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI3 26) chain A residue 918-923 type TOPO_DOM sequence RGLSND description Periplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI3 27) chain A residue 992-1004 type TOPO_DOM sequence GAGSGSQHAIGTG description Periplasmic => ECO:0000269|PubMed:10187844 source Swiss-Prot : SWS_FT_FI3

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