eF-site ID 2v30-A PDB Code 2v30 Chain A click to enlarge Title Human orotidine 5'-phosphate decarboxylase domain of uridine monophospate synthetase (UMPS) in complex with its product UMP. Classification LYASE Compound OROTIDINE 5'-PHOSPHATE DECARBOXYLASE Source Homo sapiens (Human) (PYR5_HUMAN) Sequence A:  LYFQSMELSFGARAELPRIHPVASKLLRLMQKKETNLCLS ADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKE LITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWA DLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSL ATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTP GVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAA DRLEAAEMYRKAAWEAYLSRLG Description Functional site 1) chain A residue 257 type sequence S description BINDING SITE FOR RESIDUE U5P A1480 source : AC1 2) chain A residue 259 type sequence D description BINDING SITE FOR RESIDUE U5P A1480 source : AC1 3) chain A residue 281 type sequence K description BINDING SITE FOR RESIDUE U5P A1480 source : AC1 4) chain A residue 283 type sequence H description BINDING SITE FOR RESIDUE U5P A1480 source : AC1 5) chain A residue 312 type sequence D description BINDING SITE FOR RESIDUE U5P A1480 source : AC1 6) chain A residue 314 type sequence K description BINDING SITE FOR RESIDUE U5P A1480 source : AC1 7) chain A residue 371 type sequence M description BINDING SITE FOR RESIDUE U5P A1480 source : AC1 8) chain A residue 372 type sequence S description BINDING SITE FOR RESIDUE U5P A1480 source : AC1 9) chain A residue 417 type sequence P description BINDING SITE FOR RESIDUE U5P A1480 source : AC1 10) chain A residue 430 type sequence Q description BINDING SITE FOR RESIDUE U5P A1480 source : AC1 11) chain A residue 432 type sequence Y description BINDING SITE FOR RESIDUE U5P A1480 source : AC1 12) chain A residue 450 type sequence G description BINDING SITE FOR RESIDUE U5P A1480 source : AC1 13) chain A residue 451 type sequence R description BINDING SITE FOR RESIDUE U5P A1480 source : AC1 14) chain A residue 317 type sequence D description BINDING SITE FOR RESIDUE U5P B1479 source : AC2 15) chain A residue 318 type sequence I description BINDING SITE FOR RESIDUE U5P B1479 source : AC2 16) chain A residue 321 type sequence T description BINDING SITE FOR RESIDUE U5P B1479 source : AC2 17) chain A residue 312 type ACT_SITE sequence D description For OMPdecase activity => ECO:0000269|PubMed:18184586 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 314 type ACT_SITE sequence K description For OMPdecase activity => ECO:0000269|PubMed:18184586 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 317 type ACT_SITE sequence D description For OMPdecase activity => ECO:0000269|PubMed:18184586 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 309-322 type prosite sequence IFEDRKFADIGNTV description OMPDECASE Orotidine 5'-phosphate decarboxylase active site. IFeDrKfaDIGnTV source prosite : PS00156 21) chain A residue 257 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18184586, ECO:0007744|PDB:2QCD source Swiss-Prot : SWS_FT_FI2 22) chain A residue 317 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18184586, ECO:0007744|PDB:2QCD source Swiss-Prot : SWS_FT_FI2 23) chain A residue 321 type BINDING sequence T description BINDING => ECO:0000269|PubMed:18184586, ECO:0007744|PDB:2QCD source Swiss-Prot : SWS_FT_FI2 24) chain A residue 259 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18184586, ECO:0007744|PDB:2QCD, ECO:0007744|PDB:2QCH source Swiss-Prot : SWS_FT_FI3 25) chain A residue 372 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18184586, ECO:0007744|PDB:2QCD, ECO:0007744|PDB:2QCH source Swiss-Prot : SWS_FT_FI3 26) chain A residue 430 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:18184586, ECO:0007744|PDB:2QCD, ECO:0007744|PDB:2QCH source Swiss-Prot : SWS_FT_FI3 27) chain A residue 450 type BINDING sequence G description BINDING => ECO:0000269|PubMed:18184586, ECO:0007744|PDB:2QCD, ECO:0007744|PDB:2QCH source Swiss-Prot : SWS_FT_FI3 28) chain A residue 281 type BINDING sequence K description BINDING => ECO:0000269|PubMed:18184586, ECO:0007744|PDB:2QCL source Swiss-Prot : SWS_FT_FI4 29) chain A residue 314 type BINDING sequence K description BINDING => ECO:0000269|PubMed:18184586, ECO:0007744|PDB:2QCL source Swiss-Prot : SWS_FT_FI4

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